The adrenal glands and the central nervous system were studied from five human cases of rabies who died three to six days after first rings of clinical manifestations were seen. In all cases there were Negri bodies in the cytoplasm of neurons of the central nervous system and mononuclear inflammatory cells around blood vessels, more intense in the cases with longer survival. Only the adrenal medulla showed diffuse and intense mononuclear exudate associated with pheocromocytes alterations in 60% of patients. Eosinophilic bodies were found in the cytoplasm of pheochromocytes and in the interstitial space. These bodies may be similar to Negri bodies but their true nature it is not known. The pathogenesis of adrenal medullitis in rabies may be related to embryological and metabolical relationships of the chromaffin system and the nervous system.

Adrenal Gland Diseases↗

PubMedDate not supplied

[Cutaneous melanoma: clinical versus anatomopathological diagnosis].

In order to estimate the ability of physicians to make the clinical diagnosis of cutaneous malignant melanoma, a retrospective study was carried out. A comparison between clinical hypothesis and histopathological diagnosis was assessed. The rate of diagnostic accuracy was only 51%. There were problems in the differential diagnosis between malignant melanoma and other pigmented skin lesions. The majority of the cases of melanoma was recognized in advanced stages of tumor invasion. These data point out toward the need of improving the skills of the general physicians in the clinical recognition of the cutaneous melanoma and its precursor lesions.

Adolescent↗

PubMedDate not supplied

[Idiopathic acute fatty liver in pregnancy. Clinico-pathological study of 3 cases].

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Adult↗

PubMedDate not supplied

[Comparative study of the suture of pancreatic stump with absorbable and unabsorbable threads in rats].

The safety of suture and healing of pancreas after surgery with absorbable and unabsorbable suture was studied. One hundred and twenty female rats was underwent a segmentar pancreatic resection. The pancreatic suture was performed with catgut in Group I (n = 48), polygalactin in Group II (n = 48) and silk in Group III (n = 24). The animals were sacrificed at 5th, 10th, 20th and 30th days after surgery and analized at macroscopy: inflammatory signs, fistula, abscess and suture bearing in tissue. Microscopic findings were: suture bearing in tissue, inflammatory aspects against suture, necrosis, edema, neovascular modifications, fibrosis and the collagen's type. After comparing the results with Wilcoxon's two sample test, we concluded that pancreatic healing was not modified with differents sutures, and then pancreatic absorbable or unabsorbable suture was safe.

Animals↗