PubMed Health⌕ Search

Biomedical subjects

H Gofferje

Publications and source records attributed to H Gofferje.

At least 19 recordsLinked to original sources
PubMed1981

[Stress-metabolism after myocardial infarction-demonstrated by means of the behaviour of plasma proteins with short half-life (author's transl)].

The kinetics of plasma proteins with short half-life during stress-metabolism in patients after myocardial infarction with and without clinical complications and after angina pectoris were compared. The acute-phase proteins alpha1-antitrypsin, C-reactive protein (CRP), fibrinogen, haptoglobin, and the transport proteins prealbumin and transferrin were analyzed with the method of radial immunodiffusion. Whereas angina pectoris doesn't influence the protein kinetics, one can recognize after myocardial infarction a continuous increase of the acute-phase proteins to maxima between the 3rd and 5th day after the attack. Parallel to these changes, the transport proteins decrease with subsequent increase. The changes, which are similar to those seen after surgical trauma, are dependent on the severity of illness, and can be used as prognostic parameters. During stress metabolism, the concentrations of the proteins depending on nutrition, prealbumin and transferrin, are modified by the type and severity of stress, and by nutritional influences. The mechanisms of these changes and the consequences for their use as diagnostic parameters are discussed.

Aged↗
PubMed1979

[Nutritional states in a medical clinic].

The nutritional state of 168 patients in a medical clinic was determined with the following parameters: Weight/height index, triceps skin fold, arm muscle circumference, creatinine/height index, albumin, prealbumin, transferrin and cholinesterase. Using these parameters we found that 51.2% of these patients were suffering from malnutrition (26.2% marasmus, 7.7% kwashiorkor-like syndrome, 17.3% marasmic kwashiorkor). Triceps skin fold, arm muscle circumference and creatinine/height index were the most precise parameters to confirm marasmus. Prealbumin and cholinesterase are especially recommended to determine acute protein deficiency, albumin to confirm chronic protein deficiency. It was also possible to demonstrate the deleterious effect of malnutrition on the immunological system of the patient through determination of the absolute lymphocyte count in peripheral blood and intracutaneous testing with streptokinase-dornase, mumps skin test antigen and candida vaccine.

Aged↗
PubMed1979

[The effect of combined parenteral-peroral nutrition on the protein status of undernourished elderly patients].

Eight elderly undernourished patients with bronchopneumonia were admitted into the clinic for treatment as well as intentive, combined parenteral-peroral nutrition. The improved protein status achieved was evidenced by a significant increase in the serum concentration of total protein, prealbumin and retinol-binding protein. There was a significant decrease of haptoglobin in all patients, measured in the upper normal range, even though it was extremely high at the onset of therapy due to the inflammatory process. These findings emphasize the influence of consequent nutritional therapy in the treatment of pneumonia, especially for elderly patients.

Aged↗
PubMed1979

[Diagnosis of malnutrition].

A diagnostic program for routine determination of the nutritional status during initial examination is presented. This program includes anthropometric methods (body weight, height, triceps skin fold, circumference of mid-arm muscle) and chemical parameters (creatinine index, albumin, prealbumin, cholesterinase). In addition, determination of the immune status through the absolute lymphocyte count in peripheral blood and intracutaneous testing with streptokinase-dornase, mumps skin test antigen and candida vaccine is recommended. This test plan allows assessment of fat stores, muscle mass, functional proteins and immune competence. The results of this study should be considered when planning adequate nutritional treatment. The results obtained for 168 patients in this test program are reported.

Antibody Formation↗
PubMed1978

[Trichinosis: epidemiology, clinical features and diagnosis (author's transl)].

After ingestion of wild boar meat 58 patients developed typical clinical signs and symptoms of trichinosis. All patients had marked blood eosinophilia. In 45% of the patients GOT and GPT and in 62% HBDH were moderately increased, while in 76% LDH and in 86% creatine-kinase showed abnormally high values. CK-MB was increased in three patients. 92% of muscle biopsies showed typical morphological changes in skeletal muscles. Latexagglutination, complement-fixation and agar-gel diffusion tests were not reliable. In most of the examined cases clinical symptoms and histological results correlated well with the indirect haemagglutination test, the microprecipitation test with living larvae of Trichinella spiralis and evidence of specific antibodies (IgG, IgM, IgE) by indirect immunofluorescence and the ELISA technique. 25 patients were treated with thiabendazole (Minzolum), 19 of them successfully.

Alanine Transaminase↗
PubMed1978

[Behavior of prealbumin, retinol-binding protein, transferrin and haptoglobin in the postoperative and post-traumatic phase].

The plasma proteins pre-albumin, retinol-binding protein, transferrin, and haptoglobin were determined in 3 different groups of surgical patients (8 patients after inguinal or incisional hernia operation, 12 patients with peritonitis due to insufficient anastomoses, 17 patients with skull-brain injuries) according to the radial immune diffusion method. The decrease in concentration of nutrition-dependent plasma proteins, pre-albumin, retinol-binding protein and transferrin, varied depending on the extent of postoperative or posttraumatic catabolism and respective nutritional regimen. The increase in concentration of the acute phase protein haptoglobin was not significantly dependent on the severity of trauma. There was, however, a further haptoglobin increase of significance due to postoperative peritonitis complication.

Haptoglobins↗
PubMed1978

[Supplement of the diet of malnourished geriatric patients with essential amino acids (author's transl)].

A significant improvement in the protein metabolism of twelve malnourished geriatric patients was achieved during a three-week daily supplement of the hospital diet with 9 g essential amino acids (8 classic essential amino acids plus histidine). This was especially evident in the doubled serum concentration of pre-albumin and retinol-binding-protein which may be regarded as highly sensitive parameters of protein metabolism. There was a significant increase of total protein and hemoglobin into the lowest normal range. The immunoglobulins IgG, IgA and IgM, however, remained unchanged for the entire observation period.

Age Factors↗
PubMed1977

[Practice in infusion therapy and parenteral feeding].

Today, the steadily growing selection of industrially produced infusion and nutritive solutions can hardly be overlooked by the clinician. It is therefore most important for him to limit himself to a number of modern, clinically approved solutions whose composition, maximal infusion rate, indications, contra-indications and side-effects are well known to him. Moreover, a successful infusion therapy and parenteral nutrition postulate the mastery of modern infusion techniques.

Acid-Base Imbalance↗