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Biomedical subjects

H Gomibuchi

Publications and source records attributed to H Gomibuchi.

12 recordsLinked to original sources
PubMed2000

A case of a primary ovarian leiomyosarcoma.

A primary ovarian leiomyosarcoma is extremely rare. Moreover, there is no established treatment modality other than surgery, and the prognosis is extremely poor. We report a case of a primary ovarian leiomyosarcoma. The patient was a gravida 4, para 2, 73-year-old female. She first presented with chief complaints of constipation and a pelvic mass. A physical examination revealed a solid tumor in the pelvic cavity. Which was about the size of an infant's head and had an irregular shape. The patient was suspected of having a subserosal myoma of the uterus or an ovarian tumor, and she was subjected to a laparotomy. A solid tumor about the size of an infant's head was found in the left uterine adnexa, and an intraoperative rapid pathological diagnosis of an ovarian leiomyosarcoma was made. A total abdominal hysterectomy, a bilateral salpingo-oophorectomy, a pelvic lymphadenectomy, and an omentectomy were then performed. The final pathological diagnosis confirmed a left primary ovarian leiomyosarcoma. After a series of discussions with the patient's family about her therapeutic plan, we decided to let the patient be followed-up without adjuvant therapy. Forty-two months after the surgery, the patient accumulated massive amounts of pleural effusion and ascites, with extensive organ metastasis. She received terminal care and soon died.

Aged↗
PubMed1993

Is personality involved in the expression of dysmenorrhea in patients with endometriosis?

OBJECTIVE: To investigate whether a relationship exists between personality and expression of pain in women with endometriosis. STUDY DESIGN: With use of the Rosenzweig picture frustration study, the personality of women with endometriosis was assessed. These results were then correlated with the manifestation of pain. RESULTS: Women without dysmenorrhea tended to be less assertive compared with women who complained of dysmenorrhea and women without endometriosis. Those women without dysmenorrhea showed a destructive attitude in face of a problem. CONCLUSIONS: Personality affected the expression of pain. Pain caused by endometriosis was influenced by each personality type.

Adult↗
PubMed1990

[Influence of peritoneal fluid with endometriosis on the development of mouse embryos].

To clarify the mechanism of infertility associated with endometriosis (EM), the effect of peritoneal fluid (PF) on early embryogenesis was examined. The addition of PF (5%) had no effect on the development of mouse 2-cell embryos. Since the PF is supposed to enter the oviductal cavity, PF may influence reproductive processes by modulating the intraoviductal microenvironment. As expected, PF with EM inhibited the development of 2-cell embryos co-cultured with oviducts whereas PF without EM had no effect. An increase in interleukin 1 (IL-1) has been identified in PF with EM. As with PF with EM, IL-1 inhibited the development of 2-cell embryos inasmuch as the oviducts were co-cultured. Indomethacin, an inhibitor of prostaglandin (PG) synthesis, effectively abolished the inhibitory action of both PF with EM and IL-1 on embryonic development. Moreover, PGE2 directly inhibited embryonic development. PGE2 was shown to inhibit the synthesis of protein by early embryos. These results demonstrate that PF with EM inhibits the development of early mouse embryos by acting on the oviducts. From these results it seems that an increase in IL-1 may be a causative factor in the embryo-toxic properties of PF with EM. We further suggest that PGE2 secreted from the oviducts by stimulation with PF with EM, may be an ultimate contributing factor in embryo-toxicity by inhibiting protein synthesis by early embryos.

Animals↗
PubMed1985

[Traumatic mitral insufficiency: a case report].

A 25-year-old man was admitted to Juntendo University Hospital with chief complaints of nocturnal dyspnea and shortness of breath on Sept. 22, 1983. He had no history of rheumatic fever or bacterial endocarditis. He was violently kicked in the chest while practicing Shorinji-Kempo (Karate) in July 1977. His heart murmur was first noticed in April 1978, but he was asymptomatic for six years after the accident until transient nocturnal dyspnea developed January 1983. Physical examination on admission revealed a grade 4/6 apical holosystolic murmur, a markedly accentuated third sound, and hepatomegaly of two finger breadth in the right midclavicular line. An electrocardiogram revealed sinus tachycardia (100/min), left atrial overload and left ventricular hypertrophy. Chest radiography showed slight cardiac enlargement with a cardiothoracic ratio of 55%, and slightly increased pulmonary vascular markings. Two-dimensional echocardiography showed a markedly prolapsed posterior mitral leaflet and fluttering in diastole. Cardiac catheterization showed elevated pressure of pulmonary capillaries (a: 16, v: 30, mean: 19 mmHg), the pulmonary artery and the right ventricle. Left ventriculography revealed grade four (Sellers) mitral regurgitation. Mitral valve replacement was performed on October 13, 1983. A chorda tendinae supporting the posterior leaflet of the mitral valve was found to be ruptured just above its origin from the posterior papillary muscle. Histological examination of the resected valve showed increased spongiosa tissue which mimicked so-called myxomatous changes, but it seemed preferable to interpret this as a "secondary change due to increased hemodynamic stress" rather than the "primary change".

Adult↗