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Biomedical subjects

H Grasshoff

Publications and source records attributed to H Grasshoff.

At least 37 records · Page 2Linked to original sources

Structural bone grafting in arthroplasty for congenital hip dysplasia: 35 hips followed for 5-10 years.

We assessed 35 hip arthroplasties in 30 patients with an average follow-up of 7 years. All patients suffered from secondary osteoarthrosis due to congenital dysplasia. The mean age at the time of surgery was 54 (19-77) years. Part of the femoral head used as a graft was fixed to the superolateral region of the acetabulum. A 100% bone coverage of the acetabular component was achieved initially. The mean support by the graft was 34%. The graft size, measured in the AP view, decreased on average 29% after 7 years. The resorption caused a reduction in cup coverage to 94%. There was no correlation between the clinical outcome and the graft size. Graft resorption occurred in the horizontal and vertical axes, but hardly affected the contact region with the iliac bone. Radiolucent lines according to DeLee were found in zone I in 4, zone II in 6 and zone III in 7 cases. The Harris Hip Score improved from 37-85 points. 1 revision was necessary 7 months postoperatively after cup dislocation.

Adult↗

[Vertebragenic dysphagia].

UNLABELLED: Dysphagia due to external compression by anterior hyperostosis of the cervical spine is rare. The diagnosis may be established by conventional X-ray of the spine, oesophagogram, CT or MRI. CASES: We operated on one patient with an exostosis on the axis and another patient with large anterior osteophytes from C3 to C7 in Forestiers's disease. Postoperatively the patients were asymptomatic. CONCLUSIONS: Painful dysphagia due to anterior hyperostosis of the cervical spine is an indication for surgery. The anterolateral extrapharyngeal approach from C3 to C7 and the transoral intrapharyngeal approach to the vertebra C2 are preferred. In cooperation between orthopaedics and ENT the surgical treatment has no major complications and gives good functional results.

Cervical Vertebrae↗

[Bilateral and simultaneous quadriceps tendon rupture in secondary hyperparathyroidism. A case report].

A case of bilateral simultaneous rupture of the quadriceps tendon without significant trauma is presented. Generally there is an association with chronic metabolic disorders, such as chronic renal failure and secondary hyperparathyreoidism, as well as hormonal diseases. The ruptures appeared in a 34-year-old man with chronic renal failure and severe secondary hyperparathyreoidism. Etiology, diagnostic procedures and treatment in comparison with the international literature are described. We discuss the value of ultrasound screening as a diagnostical and follow-up tool.

Adult↗

[Long-term outcome of Putti-Platt operation in recurrent traumatic ventral shoulder dislocations].

In the present study, we reviewed 25 patients who had been treated by Putti-Platt procedure for recurrent traumatic anterior shoulder dislocations between 1988 and 1991. The average follow up time was 6.8 years. Redislocations occurred in nine cases (36%), five of these patients had to undergo a second shoulder reconstruction. Clinical examination with exclusion of the reoperated patients revealed signs of instability in further six patients. Six patients showed decreases in external rotation of more than 40 degrees compared with the nonoperated shoulder. According to the Rowe-score, results were judged as excellent or good only in 55% while they had to be estimated as poor in 30%. At follow up, 13 patients still suffered from limitations in their shoulder functions, only six out of 15 patients were able to return to their sporting activities postoperatively. Thus, the Putti-Platt procedure revealed rather disappointing long-term results and cannot be recommended.

Adolescent↗

Functional characterization of mitochondrial oxidative phosphorylation in saponin-skinned human muscle fibers.

The conditions of treatment of human skeletal muscle fibers from M. vastus lateralis with saponin were optimized to achieve complete permeabilization of cell membrane at intact mitochondrial oxidative phosphorylation. After 30 min of incubation with saponin all lactate dehydrogenase, 50% of creatine kinase, 30% of adenylate kinase and less than 20% of citrate synthase was released into the permeabilization medium. These skinned fibers behave similar to isolated mitochondria from human skeletal muscle: (i) the respiration with mitochondrial substrates can be stimulated by ADP, (ii) inhibited by carboxyatractyloside and (iii) it is possible to detect fluorescence changes of mitochondrial NAD(P)H on additions of substrates, uncoupler and cyanide. From a comparison of rates of respiration per cytochrome aa3 content of isolated human skeletal muscle mitochondria and saponin-skinned muscle fibers it was possible to calculate that almost 85% of mitochondria in those fibers are accessible for the investigation of oxidative phosphorylation. As shown by the investigation of biopsy samples of two patients with undefined myopathies these fibers are a suitable object for the replacement of isolated mitochondria in the diagnosis of mitochondrial myopathies and encephalomyopathies.

Animals↗

[The morphological relations of eugnathia and class-II/1 and class-III malocclusions to the changes in the topography of the cervical spine in the lateral teleroentgenogram].

Relations are discussed between malocclusions and changes of the vertebral spine. It was the aim of our investigations to disclose the causal relations between changes of the position of the cervical spine and class-II/1 anomalies (49 patients), class-III anomalies (28 patients), and eugnathic maxillary conditions (50 children). 127 lateral cephalograms of the untreated 63 boys and 64 girls at the age from six to 13 years were evaluated according to 24 orthodontic and 25 orthopedic characteristics. Patients with class-II/1 anomalies and class-III anomalies showed the tendency to strongly marked lordosis of the cervical spine. The basal angles nasion-tuberculum sellae-opisthion, nasion-tuberculum sellae-basion, and nasion-dorsum sellae-basion were enlarged in class-II/1 cases and reduced in class-III cases. It could not pointed out relations between the sagittal position of the jaws and the position of the atlas; there was no existing a specific bearing of the head within the various groups.

Adolescent↗

[CT diagnosis in instability of the shoulder joint].

CT is able to demonstrate the predisposing factors for recurrent and posttraumatic subluxation of the shoulder. In addition to demonstrating bony changes in the glenoid (Bankart lesion) and in the humeral head (Hill-Sachs lesion), CT can measure the degree of retroversion of the glenoid and torsion of the humerus. Measurements on 17 shoulders with habitual and 24 shoulders with recurrent posttraumatic subluxation showed low values for glenoid retroversion as compared with a control group. Particularly patients with habitual anterior subluxation frequently showed anteversion of the glenoid. Measurements of humeral torsion showed wide scatter amongst all groups, indicating wide biological variability. The results were compared with those published in the literature and the indications and limitations of CT for the investigation of shoulder instability are discussed.

Humans↗

[Perioperative antibiotic prophylaxis in allo-arthroplasty].

Since 1984 the perioperative prophylaxis was carried out using the antibiotics Oxacillin or Halospor in artificial joint replacement of the hip. We started with 1 g Oxacillin at the very beginning of the anaesthesie. Further 0.5 g Oxacillin were administered 2 and 6 hours later. 964 hip joints operated between 1982-1988 were followed up. We observed a marked decrease of the rate of infection from 7.2% to 1.0% after the introduction of the perioperative prophylaxis.

Hip Prosthesis↗

[Hip joint endoprosthesis and metal sensitivity. Studies using the leukocyte migration test].

The Leukocyte-Migration-Test (LMT) is a sensitive method for the proof of metal sensitivity in organism. There were no difference in the sensitivity of chromium, cobalt and/or nickel in 42 patients suffering for coxarthrosis and 41 patients after total hip replacement. We found no connection between metal sensitivity and loosening of artificial hip joints in two groups of patients suffering as well from metal sensitivity as from loosening of the artificial hip joint.

Cell Migration Inhibition↗