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Biomedical subjects

H Greve

Publications and source records attributed to H Greve.

35 records · Page 2Linked to original sources

[Intracutaneous skin suture with a resorbable synthetic monofilament suture].

We report about our good experience with a monofile, synthetic, absorbable Polydioxanone thread used for skin suture in an intracutaneous technique, after we performed more than 1,500 sutures of 7 to 30 cm length in patients of any age. We consider the suture to be suitable for children to achieve a cosmetically fine scare without a subsequent necessity to pull out the thread. The breaking strength, the absorbtion rate and the loss of inflammatory reaction is so satisfactory that we could not see any disadvantage by using this absorbable, synthetic thread for skin closure. Especially there was no disturbance in wound healing. In contrast, because of the secure and undisturbed wound-edge adaptation a non-irritant, firm, and hairline-like scar could be achieved. The time to carry out the suture is no longer than for other techniques.

Dermatologic Surgical Procedures↗

[Closure of median sternotomy with resorbable synthetic sutures].

To date, the refixation of the bone halves after median sternotomy is accomplished with wire, steel bands or thick, not absorbable plastic threads. As the first, we used absorbable synthetic strings in 25 patients. During the absorbtion the development of a very strong bone scar was possible, because the absorbtion lasted very long. The refixation of the sternum in cases of aseptic instability was even possible. So we think to have found another range of application for absorbable synthetic material which recently has been used more and more in several parts of operative medicine, even in hard burdened connective tissue.

Adolescent↗

[Surgical treatment of the abnormal origin of the left coronary artery from the pulmonary artery. The Bland-White-Garland syndrome].

Seven children aged 6 weeks to 9 months with anomalous left coronary artery originating from the pulmonary artery and a 46-year-old female patient with pronounced formation of collaterals in Bland-White-Garland syndrome and left-right shunt were operated between July 1976 and February 1984. All children had already experienced left ventricular anterior wall infarction. Angiocardiography in 6 cases established the diagnosis, in one case echocardiography had proved sufficient. In the children, close-to-origin ligation of the left coronary artery was done after median sternotomy. One child succumbed postoperatively whereas in all others preoperative cardiac insufficiency regressed satisfactorily. In the adult female close-to-origin cutting of the left coronary artery was followed by aorto-coronary venous bypass.

Cardiomegaly↗

[Regeneration of the trachea following partial or total replacement by synthetic resorbable material (polyglactin 910)].

Though longer distances of the trachea and segments of the bronchi can be resected and the blunts be joined by end-to-end anastomosis, the replacement of parts of the wall of the tracheobronchial tree may become necessary. Alloplastic not absorbable material like silicone was not successful because of its disposition to infections and development of stenosis. Absorbable suture material proved to be suitable in tracheal surgery and it was shown that texture of Polyglactin 910 (Vicryl) could even be used for replacement of the aortic wall. We used weaved tubes of 2.5 mm diameter as prostheses of this material. We partly resected the trachea in the throat of 30 rats and in a microsurgical procedure we replaced in 17 animals the whole circumference by the tube shaped prosthesis and in 13 animals a window in the trachea by a patch, cut from such a prosthesis. By pneumonia or granulation in the anastomosis region 11 rats died or had to be sacrificed untimely. The others survived in several periods up to 10 weeks. At the time of autopsy starting after 3 weeks, a newly formed trachea could be demonstrated, which is covered more and more with respiratory epithelium. By light microscopic and scanning microscopic examinations, the development of a new wall, similar to the normal one, was seen. This wall lacks only mucus glands, but contains structures similar to hyaline cartilage. Our absorbable prosthesis cannot prevent the development of stenosis by overshooting granulation in the early postoperative period, but very soon the material is absorbed and replaced by a structure similar to the normal wall. After biodegradation, problems appear by instability of the new tissue, because of collapsing during inspiration. This problem could be solved by covering the prosthesis by an additional supporting scaffold.

Animals↗

[Refixation of osteochondral fragments using absorbable plastic pins].

The authors report on the fixation of cartilage-bone fragments via an (absorbable) PDS rod. The study was conducted with 18 rabbit knee joints. Good healing of the fragments was seen over a period of 10 weeks. In vitro examinations of the rod showed satisfactory tearing and bending strength with only slow deterioration of strength due to hydrolysis. On the basis of these studies the authors believe that the rods are suitable for fixing small fragments in accident surgery. Other fields of application are possible and require to be investigated.

Animals↗

[Indications for operative intervention in acute and acute recurring lung embolism].

From 1973 to 1983 10 patients suffering from pulmonary embolism were seen at our clinic. All 10 underwent cardiopulmonary bypass and embolectomy of the pulmonary truncus and its branches including exploration of the right heart. 6 patients survived. The embolectomy of the pulmonary artery was supplemented by clipping the inferior vena cava. In chronic recurrent pulmonary embolism we only performed the clipping procedure of the inferior vena cava.

Acute Disease↗

Surgery of coarctation of the aorta: a nine-year review of 253 patients.

From 1973 to 1982, 253 patients--164 males and 89 females--underwent an operation for coarctation of the aorta in our clinic. Of the patients 72.3% presented with a circumscribed lesion and 58.5% with associated congenital cardiovascular defects. Resection with end-to-end anastomosis was performed in 138 patients (54.5%). Seventy-four patients (29.3%) had vascular graft prosthesis, 1.2% underwent the Clagett's operation, 9.1%, the indirect isthmoplasty and the rest (5.9%), the subclavian flap plastic. Ventricular fibrillation led to the intraoperative death of 3 infants with associated intracardiac and multiple somatic defects. The operative mortality was high in children under 15 months (13.2%), 1% in all the others taken together and 0% in all cases without concomitant lesions. Paraplegia occurred in only one patients (0.4%). One hundred twenty-eight patients were followed-up over a mean period of 3.6 years. The systolic and diastolic pressures decreased by a mean of 30 mmHg and 15 mmHg respectively. Eighty-seven patients (68%) had normal blood pressure at the time of examination. The rest (41 patients) had persistent postoperative hypertension necessitating medical management. The surgical technique elected did not influence the level and incidence of persistent postoperative hypertension, rather the level of the preoperative systolic right arm-to-leg pressure gradient (SPG) related closely to the incidence of persistent hypertension. Thirty patients (23.4%), among whom were 24 children under 10 years--some of them with preductal hypoplasia--presented with an SPG above 20 mmHg.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

[Surgical treatment of anomalies of the thoracic aorta].

The surgical treatment of five patients aged from 15 to 25 years and affected with interrupted aortic arch without associated cardiac malformations is reported. Furthermore, 28 patients suffering from atresia of the aortic arch were operated upon. Vascular rings of the aorta were found with a double aortic arch in 4 children while 7 patients had an arteria lusoria.

Adolescent↗

[Surgical closure of persistent ductus arteriosus in small premature infants in an incubator].

In premature neonates a patent ductus arteriosus causes often other complications thus the immediate closure of the patent ductus arteriosus should be preferred or recommended. Performing the surgical closure of the ductus within the incubator can avoid complications during transportation from the premature neonates intensive care unit to the operating room. 25 very small premature neonates or those with another burden in addition were operated upon in the incubator on the premature infants intensive care unit of our hospital during the period from January 1987 to April 1989. No complications occurred during the operation, especially not caused by the strange circumstances for the operating team. Wound infections because of possible bacterial contamination of the incubator or the room were not observed during the postoperative period.

Ductus Arteriosus, Patent↗