[Dermatologic indications for depot corticosteroids].
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Biomedical subjects
Publications and source records attributed to H Grimmer.
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The application of sublesional injections by using Triamcinolone Acetonide crystal suspension represents a method offering the possibility to achieve a maximum of effectiveness with relatively small doses. Selectively injected in the affected tissue or the immediate neighbourhood respectively the health structures can be preserved largely from undesirable side effects. In diseases chronically relapsing longer symptomless remissions can be reached than with conventional topical methods.
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Topisolon (Desoximetasone) has been used under clinical conditions on 42 patients with acute and chronic dermatoses. This was a comparative trial on symetric areas. Topisolon with the test name A 41 304 has been compared to an 0,1% triamcinolon-acetonide ointment. Topisolon showed a quick onset of action. After 14 days of treatment a good result has been seen in 88% of the cases and in only 5% the effect has been moderate. The drug has been used in psoriasis vulgaris, atopic dermatitis, and lichen ruber. No side effects or irritations have been seen except one case of candidiasis. On five diabetics treated no influence on blood sugar level could be seen.
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