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H Gudziol

Publications and source records attributed to H Gudziol.

At least 37 records · Page 2Linked to original sources
PubMed2000

[Lymph node metastases in the neck of unknown primary tumor].

BACKGROUND: Cervical lymph nodes represent the most frequent manifestation of lymph node metastases of unknown primary. Nearly 3% of all malignant ENT-tumors are cervical lymph nodes metastases of unknown primary. This disease is a challenge for clinical working physician in diagnosis and therapy. MATERIAL AND METHOD: In a retrospective study we investigated 99 patients with the diagnosis cervical lymph node metastases of unknown primary, which were treated and observed in our department between 1975 and 1995. Within this group we observed the course of 83 patients completely. RESULTS AND CONCLUSIONS: The tumor-dependent 5 year-survival-rate was 11%. This is very low, but similar to the literature. 40% of patients, that were operated on neck dissection with or without postoperative irradiation survived tumor-dependent 5 years. In 42 cases we could find a primary tumor. 14 of these primaries were located in the upper aero-digestive-tract, 28 in other regions of the body. The identification of the primary did not improve the prognosis of the patients. A good prognosis was associated with further occult primary, location of the lymph nodes in the upper or middle level of the neck or parotid region and a histology of squamous cell or undifferentiated carcinoma. Signs of poor prognosis were metastasis in the supraclavicular region, of adenocarcinoma and inoperability of the lymph node. The combination therapy of neck dissection and irradiation proved to be best. The extended field radiation of the complete upper aero-digestive-tract did not cause a improvement of tumor-dependent 5-year-survival. We discovered a primary in 5 of 27 patients in this group within the irradiated area. In conclusion extended field radiation must be discussed critically for patients with lymph node metastasis of unknown primary.

Adult↗
PubMed1997

[Adeno-tonsillar hyperplasia and obstructive sleep related respiratory disorders].

The most common cause of obstructive apnoeas in children is adenotonsillar hyperplasia. Possibilities of therapy are surgical intervention (adeniodectomy, tonsillectomy) or nasal CPAP. The decision on the most appropriate therapy must be individual. 26 children aged 2-5 years were investigated polysomnographically before therapy, after operation or with nCPAP-therapy. Polygraphy is a helpful aid in making up one's mind in favour of one of the possibilities of therapy, but also for controlling the therapeutic effect.

Adenoidectomy↗
PubMed1995

[Sense of smell].

About two million Americans suffer from anosmia. Most result from nasal obstruction, head injuries, and viral infections. Brain disorders like epileptic seizures, tumours, and dementia can distort can distort the sense of smell. Anosmia adversely affects patient well-being. Patients cannot detect spoiled food, gas leakage, or dangerous smoke. They are unable to distinguish flavour and smell the springtime or the ocean. Many products as soaps, cat litter, toilet paper, etc. are perfumed because consumers will more readily buy a product that smells nice than one that has no smell at all. Historically, the importance of odors was very different. The ancient Romans loved exotic aromas during their banquets and orgies. In the Middle Ages the church did not like fragrances. The French revolution of 1789 brought a revolution of deodorization to Europe. Today, fragrance companies' increasing sales are an indication of the power of odor.

Humans↗
PubMed1995

[Salivary gland diseases].

Only about 1% of head and neck tumors are neoplasms of the salivary glands. The majority [80%] of these tumors are benign. Pleomorphic adenomas, the most frequent benign tumors of the salivary glands, can transform into malignancy, especially after a long duration. Treatment of salivary gland tumors consists of complete surgical excision by a surgeon experienced in microsurgery of the facial nerve. Acute suppurative and viral sialadenitis is usually treated by the general practitioner either symptomatically or, if possible, specifically. Chronic sialadenitis, sialadenosis, Sjögren's syndrome, and Frey's syndrome often need long-term follow-up and medical treatment, which is also usually delivered by the general practitioner, after the diagnosis has been established. Trauma to the salivary gland with transsection of the duct or facial nerve needs immediate microsurgical repair by an otolaryngologist. Sialolithiasis is also treated surgically in most cases.

Bacterial Infections↗
PubMed1987

[Classification and definition of smell and taste disorders].

The smell and taste disorders are defined in terms due to two principles - the type and site of lesion. The quantitative dysosmias (anosmia, hyposmia, hyperosmia) correspond to the quantitative dysgeusias (ageusia, hypogeusia, hypergeusia) and the qualitative dysosmias (parosmia, pseudo-osmia, phantosmia, agnosmia) correspond to the qualitative dysgeusias (parageusia, pseudogeusia, phantogeusia, agnogeusia). Due to the site of lesion we can differentiate between respiratory, epithelial, combined, neural, and central dysosmias as well as epithelial, neural, and central dysgeusias. Typical examples are demonstrated, denying other classifications and terms as not precisely enough or negligible ones.

Ageusia↗
PubMed1987

[Respiration olfactometry--an objectifying method in the quantitative assessment of hyposmia].

The nasal flow rate is a sensitive parameter for recording respiration reactions evoked by smelling. A method is presented for objectifying measurement of different severe hyposmias. Using the monorhine respiration-olfactometry, one side of the nose is stimulated olfactorily, in the other one the nasal flow rate is registered simultaneously. 22 patients suffering from light and severe hyposmia could be exactly classified corresponding to the severity of hyposmia. There were no smell-induced respiration reactions below the detection threshold. The reaction thresholds of respiration-olfactometry correspond to the detection thresholds of subjective olfactometry in 94% of the patients.

Adolescent↗
PubMed1986

[Olfactory neuroblastoma. Clinical course, light microscopic and ultrastructural findings in 3 cases].

Olfactory neuroblastomas are considered to be a clinicopathological entity, but they may show variable histologic pictures. The light and electron microscopic features of 3 cases as examples for the possible range of morphological findings are presented. This report is also aimed at defining essential diagnostic features, at discussing the differential diagnosis and finally at making pathologists more familiar with these rare tumors. The clinical appearance of the three cases was more or less typical for olfactory neuroblastomas. The leading symptom in all patients was a nasal obstruction. Light microscopically, the neuroblast-like tumor cells were arranged in sheaths or nests. Only in case 1 there were some Flexner rosettes, and especially in case 2 numerous Homer-Wright pseudo-rosettes could be found. Somewhat spindled cells with resemblance to Schwann cells were recognized in case 1 and 3. Neither argyrophilia nor argentaffinity could be demonstrated. Neuroblast-like tumor cells in case 2 contained glycogen intracytoplasmically. The diagnostically essential electron microscopic characteristics were neurite-like cellular processes and neurosecretory granules within the cytoplasm. Corresponding to light microscopic findings in cases 1 and 3, cells with features of Schwann cells could be identified. From the literature and the results presented here the conclusion can be drawn, that in nearly all cases a definite diagnosis is possible if besides the histologic picture also clinical data and, if necessary, ultrastructural and immunohistochemical findings are considered. The most important light microscopic criteria are a fine-fibrillary intercellular substance and the occurrence of Homer-Wright pseudo-rosettes. The differential diagnosis of olfactory neuroblastomas with special regard to electron microscopic findings is discussed and some remarks on the clinical behaviour are added.

Adult↗
PubMed1986

[Olfactory neuroblastoma. 3 case reports as a contribution to the clinical aspects, morphology and prognosis].

The leading symptom in all patients was a nasal obstruction. At first all three cases of olfactory neuroblastoma were mistaken for polyposis nasi. The tumour can be diagnosed solely by histologic examination. The light microscopic as well as the ultrastructural findings demonstrated the great morphological variability of this carcinoma. In nearly all cases a definite diagnosis is possible if besides the light microscopic picture also clinical data, ultrastructural and, if necessary, immunohistochemical findings are considered. At the time of diagnosis one tumour was Kadish-stage A and two were stage C. Lokal and metastatic tumour extension, recurrence of disease after treatment, patient age and radical tumour resection at initial presentation, are prognostic important criteria. The discriminant function by Homzie and Elkon permits the oncologist to predict the patient's outcome accurately.

Adult↗
PubMed1983

[Incidence of regional metastasis in supraglottic carcinoma].

In 348 patients with supraglottic carcinoma 154 (44%) had palpable lymph nodes. Only 26% of the patients treated surgically showed histologically abnormal nodes in the neck. The incidence of regional metastasis increased to 33% including latent lymph node metastasis. There were 4 patients (5%) with positive nodes on histologic examination which had not been detected clinically (N0). In N1- and N2-patients, histologically positive nodes were found in 41% and 29%, respectively. A fixed node (N3) was nearly always a positive node. Postoperative TNM-classification is very important in terms of prognosis of the supraglottic carcinoma. The presence of metastasis in regional lymph nodes decreased the 5-year-survival rate from 64% to 43%. Because of the high frequency of lymphatic metastases of the supraglottic carcinoma, the aim of radical surgery should include the removal of regional metastases and of the potential bilateral avenues of spread. This principle is indicated even though lymph nodes may not be palpable in partial laryngectomy.

Carcinoma↗