Biomedical subjects

H Guldager

Publications and source records attributed to H Guldager.

28 records · Page 2Linked to original sources

PubMed1985

Basophil histamine release in asthma patients after in vitro provocation with Althesin and etomidate.

Our aim was to compare the histamine-releasing effect of etomidate and Althesin on basophil leukocytes from asthmatic patients and normal persons. Blood from eight asthmatic patients and six normal persons was tested for histamine release after in vitro provocation with etomidate and althesin. In the group of asthmatic patients there was a significantly higher histamine release after provocation with althesin than after provocation with etomidate at all concentrations (P less than 0.05, P less than 0.01, P less than 0.02). There was significantly higher histamine release for asthmatic patients than for normal persons after provocation with althesin at all concentrations (P less than 0.05, P less than 0.01, P less than 0.02). There was no difference between the asthma group and the normal group after provocation with etomidate. Data were analysed using Wilcoxon's and Mann-Whitney's rank sum tests. We conclude that asthmatic patients may risk bronchospasm during induction of anaesthesia with althesin, and that etomidate may be suitable intravenous anaesthetic for asthmatic patients.

Alfaxalone Alfadolone Mixture↗

PubMed1984

Danish patients' attitudes to scientific-ethical questions. An interview study focusing therapeutic trials.

One hundred and fourteen in- and out-patients from a department of internal medicine were interviewed, on the basis of a questionnaire with the following key questions: 1) Their attitudes to medical trials with man as the subject. 2) Their emphasis on informed consent. 3) Their attitudes to inclusion of patients not being able to give informed consent. 4) Their attitudes to tentative participation in 4 concrete projects. In all, 98% considered doctors' and patients' collaboration on new therapeutical methods both necessary and desirable. Eighty-eight per cent considered information of patients participating in trials a prerequisite. Eighty-six per cent accepted participation in scientific trials based on the guarantee of the doctors responsible. Of these 86%, 58% felt that a scientific-ethical committee's accept of the project implied an extra element of security. Seventy-five per cent replied that patients not being able to give informed consent themselves could be included in scientific trials. The majority, 77%, added that patients' relatives would then have to accept, 20% that such trials could be based on the participating doctors' responsibility, and only 2% that such a responsibility was to place on scientific-ethical committees. In the 4 concrete projects, answers followed a uniform trend: full information of patients was demanded by approximately 80%, and acceptance of participation resting with responsible doctors in more than 80%. Less than half of these 80% felt that evaluation by a scientific-ethical committee would add to patients' security.

Adolescent↗

PubMed1984

Bradycardia and cardiac asystole following a single injection of suxamethonium.

Twenty cases of severe bradycardia, including 12 cases of cardiac asystole, following administration of a single dose of suxamethonium to 17 adult patients are presented. Treatment consisted of i.v. atropine in 16 cases, and in four cases external cardiac massage or a precordial thump was also given. Remission was complete in all cases. The mechanism is not known, but it is suggested that i.v. administration of fentanyl at induction may enhance the tendency to bradycardia following suxamethonium. Absence of preoperative atropine may also be of importance.

Adolescent↗

PubMed1984

Changes in heart rate and impulse conduction after a single dose of succinylcholine.

The effect of 1 and 2 mg/kg b.w. succinylcholine on changes in cardiac rate and rhythm was studied in 40 fit, adult patients undergoing non-emergency surgery. Induction of anaesthesia consisted of atropine 0.007 mg/kg b.w., pancuronium 0.015 mg/kg b.w., thiopental 5 mg/kg and succinylcholine 1 or 2 mg/kg b.w. Succinylcholine 1 mg/kg b.w. intravenously resulted in a significant decrease in heart rate after 1 min. This decrease persisted after 2 min. The heart rate was unchanged 1 and 2 min after succinylcholine 2 mg/kg b.w. When the two groups were compared, no significant difference was found. No serious cardiac arrhythmias were seen. These results suggest that the larger single dose of succinylcholine is not more likely to cause severe bradycardia or asystole.

Adult↗

PubMed1984

Respiratory depression after epidural morphine in the postoperative period. Influence of posture.

Twelve females scheduled for elective lower abdominal surgery received 4 mg of morphine by lumbar epidural injection for postoperative pain relief. The patients were divided into two groups nursed postoperatively in a supine or 45 degree elevated position, respectively. Mouth occlusion pressure during CO2 stimulation was used for the determination of respiratory depression, following epidural morphine. No significant difference in occlusion pressure was found between the two groups. Within the groups a significant reduction of the occlusion pressure was found when compared with the value obtained immediately before the administration of epidural morphine. However, compared with the value obtained the day before surgery, no significant reduction of the occlusion pressure was observed. It is concluded that the 45 degree elevated position does not protect against the occurrence of respiratory depression following epidural morphine.

Abdomen↗

PubMed1983