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H H Cockrill

Publications and source records attributed to H H Cockrill.

7 recordsLinked to original sources

Ferrioxamine as a magnetic resonance contrast agent. Preclinical studies and phase I and II human clinical trials.

The preclinical and clinical trial experience with ferrioxamine (S-FDF; Salutar, Inc.) as a contrast agent for magnetic resonance imaging (MRI) is summarized. The results in 44 patients or subjects show that the drug is safe and well tolerated when given intravenously. In certain conditions, early results show that the use of this contrast agent provides more information than can be obtained with MRI alone.

Adult↗

The continent ileostomy (Kock pouch): roentgenologic features.

The principles of construction of a continent ileostomy by means of a reservoir as originally described by Kock are reviewed. Roentgenologic studies in 5 patients with such reservoirs are described. There may be a correlation of incontinence with peristaltic activity as well as nipple valve extrusion. The radiologic features are explained in terms of the anatomy of the reservoirs. One patient with postoperative ileitis is described. Roentgenologic studies may be of particular value to the surgeon in follow-up of these patients by demonstration of postoperative nipple valve extrusion and inflammatory changes in the pouch or remaining small intestine.

Adult↗

Computed tomography in leptomeningeal infections.

In a review of CT scans of 6,078 patients, 47 patients with well documented leptomeningeal infections were identified; 45 were infants or children. Most of the infections were bacterial; 53% were due to Haemophilus influenzae. The 47 patients were divided into two groups according to whether the initial scan was obtained during the acute illness (group A) or after initial treatment had been completed (group B). The 30 patients in the acute group A had 24 complications: 18 with areas of diminished attenuation in the brain parenchyma and six with dilated ventricles. Eleven patients had initially normal scans, but three of these subsequently developed complications. In group B, the 17 patients had 28 complications: nine with enlarged ventricles; eight with subdural effusion; seven with areas of diminished attenuation; and four with abscess formation. An unusually high percentage (40%) of the patients with areas of diminished attenuation had involvement of the anterior poles of the frontal lobes. Of the patients who showed this predilection for the frontal lobes, 72% had Haemophilus influenzae meningitis. CT was found to be useful in early detection of complications of leptomeningeal infections, as well as in evaluation of the extent of the lesions.

Adult↗