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Biomedical subjects

H H Heissmeyer

Publications and source records attributed to H H Heissmeyer.

9 recordsLinked to original sources
PubMed1990

High-intensity therapy versus low-intensity therapy in advanced breast cancer patients.

The aim of this study was to evaluate the significance of response to the first two cycles of FEC (5-fluorouracil, 4-epirubicin, cyclophosphamide) in patients with advanced breast cancer. A total of 99 patients entered the study. They showed either high risk criteria and were previously untreated or showed low risk criteria and were pretreated by hormonal therapies. Eighty-two patients were evaluable. In 22 (27%) who had disease progression despite two cycles of FEC, further therapeutic attempts proved ineffective, the median survival being 2.8 months. The remaining patients responded either by stable disease (SD, n = 29; 35%), by partial or by complete remission (PR, CR, n = 31; 38%). These 60 patients were randomized to two regimes of maintenance therapy: FEC every 3 weeks or LMF (leukeran, methotrexate, 5-fluorouracil) every 6 weeks. The subsequent course of the disease was not different in both arms. It was neither influenced by the quality of early response, i.e. SD, PR, CR, nor by the intensity of chemotherapy. The prognostic impact of early response to two cycles of FEC proved to be higher than other prognostic parameters in the patients examined. Thus, early response may serve as a valid guide to adapt maintenance chemotherapy in individual patients with advanced breast cancer.

Adult↗
PubMed1986

[Clinical course of cytomegalovirus infection in adults].

Between 1972 and 1984 73 patients with acute cytomegalovirus infection have been monitored. In 55 patients case history did not reveal any former disease. In 18 patients the cytomegalovirus infection was a sequela of cardiac surgery ("postperfusion syndrome"), transplantation or underlying malignant disease. After a prodromal stage which comprised unspecific symptoms in most cases various organ manifestations were noted in the course of disease. Typical cases presented hepatitis, myocarditis, Guillain-Barré syndrome with or without thrombocytopenia and (or) lympho-monocytosis. The organ symptoms were varying in degree and resolved completely within 4 to 12 weeks. Only one female patient died from congestive heart failure due to myocarditis after one year.

Adolescent↗
PubMed1980

[Oral contraceptives and benign tumorous conditions of the liver (author's transl)].

Tumorous lesions of the liver were diagnosed by means of angiography, sonography and laparoscopy in six patients on oral contraceptives for a long time. These lesions were identified as liver cell adenoma (1), focal nodular hyperplasia (4) and cavernous hemangioma (1). The relationship between oral contraceptives and liver disorders is well-known. All cases of focal nodular hyperplasia show vascular alterations which may be important in the discussion of oral contraceptives being responsible. In contrast to liver cell adenoma and hemangioma, focal nodular hyperplasia may be considered as a nodular reparative regeneration of the parenchyma following focal parenchymal necrosis due to segmental vascular occlusion (i. e. thrombosis or fibrotic intimal obliteration). This lesions can therefore not be defined as a true neoplasm. The clinical findings are uncharacteristic, whereas selective hepatic artery angiography, shows typical features that distinguish liver cell adenoma from focal nodular hyperplasia. Regular medical examinations are recommended for women on continuous oral contraceptives for more than five years, because this group of patients is threatened by serious sequelae including intrahepatic and abdominal hemorrhage.

Adenoma↗
PubMed1975

[Differentiation of cytoplasmatic, mitochondrial and lysosomal enzymes by fractional extraction of rat liver].

Enzymes of extramitochondrial, mitochondrial and lysosomal origin were differentiated by the method of fractional tissue extraction from rat liver. It could be confirmed that soluble enzymes of the extramitochondrial (cytoplasmatic) compartment (glycerine aldehydphosphate-dehydrogenase, argininosuccinate lyase) and soluble enzymes of the mitochondrial matrix can be differentiated easily according to their different intracellular localisation. Additionally, our results emphasize that soluble enzymes of both compartements and marker-enzymes of the lysosomal cell space which are known to be structurally-bound, can be differentiated too. However, the method failed to establish significant differences between enzymes located in the submitochondrial compartment (adenylatekinase, monaminooxidase and succinic-dehydrogenase) and lysosomal enzymes (cathepsin-D and N-acetyl-D-glucosaminidase).

Animals↗