Biomedical subjects

H H Keith

Publications and source records attributed to H H Keith.

4 recordsLinked to original sources

PubMed1981

Pigeon breeder's disease in children. A family study.

The findings in a family of seven with pigeon breeder's disease are reported, and the wide range of clinical and laboratory involvement is documented. An inhalational challenge and lung biopsy were performed on the 15-year-old patient who was the index case, and the diagnostic results are discussed. We emphasize the importance of thoroughly evaluating the members of the family and the environment when a patient suspected of hypersensitivity pneumonitis is encountered. All treated members responded well to therapy with steroids and ceasing exposure to antigenic material from pigeons. Serum precipitin tests to pigeon-derived antigens that were initially strongly positive in all seven family members became negative by 15 months following treatment.

Adolescent↗

PubMed1978

Meconium screening for cystic fibrosis.

In our hands, the BMC-Test Meconium has been a significant step towards the goal of developing an ideal newborn screening test for CF. It is easily performed, is highly specific, has reasonably high sensitivity, and--given its limitation of identifying only patients with CF who have intrauterine pancreatic insufficiency--is the best method of screening newborns for CF that has been devised to date. Many technical problems remain to be solved before the test can be endorsed without reservation. Because the test, as currently constituted, does not identify all potential subjects for further testing who might have CF, it should not be made mandatory. It is, however, better than other available screening methods for CF and can be praised for that benefit. The concept has indicated a valuable new direction for mass-screening possibilities and perhaps can, by future modification, be made sensitive enough to warrant universal usage.

Albumins↗

PubMed1977

Congenital lobar emphysema.

Congenital lobar emphysema is frequently a life-threatening disorder presenting in infancy. The diagnosis should be considered when the patient shows signs of respiratory distress and the x-ray demonstrates the characteristic hyperlucent lobe with compression of the surrounding lung tissue. The morphologic aspects and pathogenesis are not clearly defined, although it is thought that an abnormality of bronchial cartilage is probably associated with the development of lobar emphysema. The results of treatment by lobectomy are excellent, and the mortality with surgery is low. Consideration of nonsurgical management is worthwhile in mildly affected or asymptomatic patients. Long-term follow-up of both groups indicates a very favorable prognosis in this disease entity.

Humans↗

PubMed1977

Vascular rings and tracheobronchial compression in infants.

Five common types of vascular anomalies have been reviewed. The entities should be kept in mind when a child has stridor, respiratory distress, recurrent croup, or pulmonary infections. Use of the plain radiography, barium esophagram, bronchoscopy, and angiography has been discussed in the diagnostic workup of vascular rings. Treatment of true encircling or compressive rings is surgical.

Aorta↗