[Reactions of 1,4-pentadien-3-ones, XV: The reaction of alkylated pentadienones with phenylacetonitriles (author's transl)].
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Biomedical subjects
Publications and source records attributed to H H Otto.
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Telethermography and thermography en plaque have a high sensitivity and a low specifity. In 75% they are applied to diagnose diseases of the female breast. Data concerning diagnostic reliability differ considerably. The author emphasizes the classification of thermographies of the female breast.
The mechanical resistance of erythrocytes after gas dispersion (oxygen, resp. mixed oxygen/carbon dioxide) and treatment in the hemoresistometer was studied on human conserved fresh blood under in-vitro conditions. Xylocitin (Lidocain) was tested as to memebrane stabilizing capability. It was found that test doses of about 5 mg and 40 mg per 100 ml of heparinized fresh blood result in an increased resistance of erythrocytes against mechanical trauma.
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Hemolysis and resistance of erythrocytes were studies in-vitro in experiments on human ACD fresh blood and on heparinized fresh blood after oxygen dispersion, resp. mixed oxygen and carbon dioxide dispersion, and subsequent treatment in the hemoresistometer. Blood alkalinity increases under oxygen dispersion, acidity increases under dispersion with mixed gases. The length of the period of dispersion is more important for hemolysis than the change of pH. The hematocrit value influences the behavior of blood resistance. High values imply enhanced hemolysis. There is no significant difference of actual hemolysis values between oxygen and oxygen/carbon dioxide dispersion. A different behavior appears in the calculation of difference value of hemolysis after treatment in resistometer and the respective actual hemolysis.
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After establishing a model of ischemia, perfusion in the ischemic area was considerably disturbed. Examination by means of 133xenon-clearance after intramyocardiac injection showed strongly delayed flowing-off compared with controls. Counterpulsation accelerates the flowing-off (perfusion). Untreated control animals reveal after inducing the model ischemia a crucial decrease of ATP concentration and an excessive increase of lactate concentration in the ischemic area. Counterpulsation may inhibit further decrease of ATP in the ischemic area.
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