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H H Rummel

Publications and source records attributed to H H Rummel.

At least 55 records · Page 3Linked to original sources
PubMed1981

[Foundations for differential cytology of cervical changes. 1. Introduction and methods (author's transl)].

A brief historic account of the development of exfoliative cytology in the context of the uterine cervix is followed by discussion of the most important technical fundamentals for the preparation of cytological specimen smears. High-accuracy cytological diagnosis depends on careful preparation techniques, which is of particular importance when it comes to highly subtle differential cytology. The authors' own experience is likely to suggest that closest attention must be given to all empirical insights regarding collection of material, fixation, and staining, since this is the key for cytological specimens to provide from low technical and material input invaluable diagnostic information about most various lesions of the uterine cervix.

Cervix Uteri↗
PubMed1981

[Foundations for differential cytology of cervical changes. 2. Benign changes (author's transl)].

Causative relationships between various benign changes of the uterine cervix are discussed with reference to literature, and resulting cytomorphological substrates are presented in illustrations. Cytomorphological pictures obtained from good preparation practice often have been helpful in drawing proper conclusions as to causes of benign changes and in clarifying clinical patterns or portio changes which escaped macroscopic elucidation. Such changes may include inflammatory or degenerative lesions of differentiated aetiology, metaplastic processes in so-called transformation zones or at squamocolumnar junctions or abnormal cornification. As a rule, benign changes may be delimitated from atypical cell changes by the examiner who is aware of all direct and indirect cytological criteria.

Atrophy↗
PubMed1981

[Foundations for differential cytology of cervical changes. 3. Dysplasia and carcinoma in situ (author's transl)].

Reference is made in this paper to cytomorphological definitions as well as to epidemiological, aetiological, and pathogenetic aspects of cervical carcinomas and pertinent precancerous changes. Cytological criteria, including cytometric data of dysplastic changes, are compared to aspects of cervical carcinomas, and typical pictures are presented of various lesions. Measured cytological data proved to be suitable not only for objectivation of descriptive morphological findings, but they were found to be also useful aids for decision-making in differential cytology.--Diagnostic accuracy in the context of both dysplasias and cervical carcinomas can be in excess of 90 per cent, depending on good preparation practice and adequate diagnostic skill of the examiner.

Adenocarcinoma↗
PubMed1980

[Uterine sarcomas. Cytological diagnosis and differential diagnosis].

Cytomorphological findings in 8 cases of uterine sarcomas are being presented (2 endometrial stromal sarcomas, 2 so-called pleomorphic sarcomas, 3 leiomyosarcomas, 1 carcinosarcoma). The differential cytologic criteria are being discussed and demonstrated by microphotograms. By means of these cytologic findings in our opinion prospective cytologic diagnosis is possible also in these kinds of tumors. Final statistical conclusions in respect to cytologic criteria may only be drawn by greater numbers of cases, which can be reached only by cooperative studies on these relatively rare tumors.

Biopsy↗
PubMed1980

[Gliomatosis peritonei--a contribution to the biology of metastasising (author's transl)].

A rare case of "gliomatosis peritonei" is reported in a 16 year-old girl suffering from an adult ovarian teratoma with high-differentiated glia structures without malignancy. The histological grading of the primary tumor and its metastasis in the omentum majus seems to be contradictory to the ovarian-tumor-staging recommended by FIGO. The biological dignity of high-differentiated gliametastasis of an adult teratoma evidently allows a minimum of treatment because of good prognosis of this disease.

Adolescent↗
PubMed1979

[Vaginal metastases as the ist signs of primary occult hypernephroid kidney neoplasms].

Based on the literature and own observations it is pointed out that in cases of vaginal tumors as a rule a consequent search for tumors of the kidneys is necessary, because vaginal tumors may be metastases of primarily not identified hypernephroid carcinomas. The frequency of such metastases is reported to be about 2%. A search for kidney tumors is necessary, if histological findings of the vaginal tumor are clearly suspect for hypernephroid carcinoma, or if it cannot be clearly identified as a primary vaginal tumor or--as a metastasis--gives no certainty to be a metastasis of a primary tumor of other localization. Because of the relative statistical frequency of vaginal metastases from carcinomas of the kidneys a consiliary gynecological check up is necessary if the diagnosis of the tumor was primarily a urologic one to ensure that there are no vaginal metastases. Further diagnostic and therapeutic procedures are discussed.

Aged↗
PubMed1979

[Carcinoma of the apocrine glands of the vulva with intraepidermal spreading under the picture of invasive Paget's disease (author's transl)].

The histological findings of Paget's disease of the nipple and of extramammary localisation are well known. The relationship to the so called "adnexal carcinoma" has not become clear to this moment. We report a case of combination of invasive vulva Paget's disease and adnexal carcinoma of the apocrine vulvar glands. Our findings are discussed with the statements of literature about aetiology and pathogenes.

Aged↗
PubMed1978

[Diagnosis, therapy, and prognosis of primary reticulum cell sarcoma of the cervix uteri (author's transl)].

Until now 12 cases of primary reticulum cell sarcoma of the cervix uteri have been described in the literature. Two more cases are reported. Diagnosis is only possible after exclusion of a systemic disease. Principle rules for therapy cannot be given by these few cases. However it seems that combined surgical and radiological treatment provides the best chances for longer surviving. Experiences in chemotherapeutical treatment of reticulum cell sarcoma of the cervix uteri are not yet published. Four of the 14 patients mentioned in this study died from relapse. The prognosis of this type of cervical tumor seems to be rather good.

Adult↗
PubMed1977

[Cytologic follow-up examination of patients with a suspicious Papanicoaou type 3D smear (author's transl)].

The cytological differential diagnosis "dysplasia" was made in 176 cases between January 1968 and June 1975. An immediate microscopic diagnosis was possible in 18 cases (10.22%). 14 cases eluded further follow-up. In 144 cases, long term observation was carried out. In some cases up to 6 years. Cytological regression to a permanently negative smear occurred in 57 patients (39.58%). A microscopic confirmation of the diagnosis was not obtained in these patients. In cytologically persistent cases microscopic confirmation was obtained after varying times of observation. The cytological differential diagnosis was correct in comparison to the histologic findings in 82.6% of the cases. 62 cases of the total (43.05%) showed cytological persistence of the suspicious smear. A cytological progression became apparent in 25 cases (17.36%) and was always subjected to microscopic confirmation by cone biopsy or primary hysterectomy. In 71 cases with microscopic confirmation persistent dysplasia was found in 64.78% of the cases and a progression occurred in 30.98% of the cases. 21.12% showed carcinoma in situ, 7.04% (5) cases showed a microinvasive carcinoma and 2 cases (2.82%) showed an invasive carcinoma. Cervical dysplasias are apparently capable of regression in a large number of cases. However about 10% of the cases will show progression to a micro-invasive or invasive carcinoma after varying lengths of time. In order to avoid unnecessary operations and to improve our knowledge on the biology of dysplasias, observation with cytological diagnosis dysplasia (Papanicolaou 3D) is justified.

Carcinoma in Situ↗
PubMed1976

[Correlations between metric, cyto and histomorphological factors and thermographic findings in breast neoplasms].

Correlations between metric, cyto- and histomorphological characteristics and thermographical results of 119 carcinomas of the breast have been studied by statistical methods. For the purpose of semi-quantitative evaluation the chi2 of 14 characteristics were calculated from foursquare tables and summarized in a correlation matrix. The study revealed a significant increase of thermographically suspect pictures with increasing size, but this was independent of the depth (i.e. the distance from skin surface) of the tumors. The proportion of uncertain but not clearly suspect results was 35% with the infrared telethermovision method, in contrast to 8% with liquid crystal plate thermography. Thermographically non-suspect carcinomas (especially the negative cases with liquid crystal plate thermography) were rich in connective tissue or stroma in most cases. On the other hand, carcinomas with numerous mitoses, large cell nuclei, increased N/C-ratio and large and strongly stained nucleoli predominantly exhibited definitely suspect pictures. The significant correlation between number of mitoses, size and staining of nucleoli and the thermographic results emphasizes that, besides vascularization and altered thermo-regulatory functions, the metabolism of the tumor itself contributes to the temperature differences. The type of growth and histological grading indicate that tumors with unfavourable prognosis preferentially exhibit thermographically suspect results. The use of thermography as a screening method is restricted because of possible false negative results. On the other hand, its additional use is justified in view of the gain in information about the biological situation of suspect alterations of the breast.

Breast Neoplasms↗
PubMed1976

[Adequate treatment of micro-invasive carcinoma of the uterine cervix (author's transl)].

At the University Department in Heidelberg 58 micro-invasive carcinomas of the uterine cervix were found between 1965 and 1974. 8 cases were diagnosed in other institutions by directed biopsies. Three cases were detected during the microscopic examination of uteri removed for emergency indications and three cases were detected after hysterectomy for cytological findings indicative of carcinoma in situ of the uterine cervix. In 44 cases an optimal conization of the cervix was carried out. Microscopic examination of these cases showed early stromal invasion in 33 cases. In 6 cases a newtork infiltration was found und in 5 cases a plump infiltration was found. The incidence of radical Wertheim operations of 21 in this group is explained by cases in this group who had inadequate diagnosis prior to admission. In 8 cases the indication for the Wertheim radical hysterectomy was a carcinomatous lymphangiosis in the conization specimen. In none of these cases metastatic tumor was found in the lymph nodes although 13 to 44 lymph nodes were examined per case. In accordance with the newer literature it is recommended to limit treatment of micro-invasive changes of the uterine cervix to routine hysterectomy or to optimal conization of the cervix if certain prerequisites are met. The results of the follow-up examinations of the reported cases appear to justify this recommendation.

Adult↗