[Evaluate the HIV test correctly!].
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Biomedical subjects
Publications and source records attributed to H H Samdal.
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Detection of HIV-1 provirus in HIV-1 seronegative individuals at risk has been described in several recent reports. Some of these sero-negative individuals remain so for prolonged periods, maybe for the rest of their lives. We do not know the significance of this finding and how it relates to pathogenesis and infectiousness. However, these persons seem to represent a minor group in the population. At present, these studies do not give valid reasons to change the Norwegian approach to the follow-up of persons at risk who have been tested and found HIV-antibody negative.
Antibody dependent cell mediated cytotoxicity (ADCC) was measured against anti-D sensitized erythrocytes using various mononuclear cell populations from peripheral blood in a chromium release assay. Adherent effector cells gave stronger cytotoxicity than unseparated and non-adherent cells, and were less dependent on pretreatment of the target cells with papain. However, close correlations were found between the cytotoxicity obtained with the various effector cell populations, indicating that either of them might be used for the purpose of establishing in vitro methods to determine the clinical significance of erythrocyte antibodies. The optimal choice of effector cells is discussed.