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Biomedical subjects

H H Wagner

Publications and source records attributed to H H Wagner.

At least 19 recordsLinked to original sources
PubMed1997

[Use of natural medicines in women referred to specialists].

The aim was to examine how often women referred to office gynaecologists were using self-medication of "natural medicines". By interview-questionnaires 62 gynaecologists asked 5.664 women about their age, name of used natural medicine and how the user felt it helped her. One thousand six hundred and sixty-four used natural medicine with 91 different names. About 75% percent of the users registered one or more effects, characterized as "good for everything", "enhances their wellbeing" "gives more energy", "relieves hot flushes and sweatings", "relieves rheumatic pain", or "is diuretic". The effects seem to be a universal stimulation of the general condition, effectuated either by vitamins and minerals or by placebo-effect. One third of the users of "melbrosia" registered a good effect on climacteric discomfort. It was not possible by laboratory analyses to find any sex-steroids in melbrosia. Nor was it possible to demonstrate biological oestrogenic effect on animals (mice and rats) of this drug in a trial done by Niels Einer-Jensen et al (personal communication).

Adult↗
PubMed1994

Controlled trial of high- versus low-dose aspirin treatment after percutaneous transluminal angioplasty in patients with peripheral vascular disease.

Percutaneous transluminal angioplasty of aortoiliac and femoropopliteal atherosclerotic lesions can provide long-lasting hemodynamic improvement. High-dose aspirin is commonly prescribed as reocclusion prophylaxis, but low doses would be preferable because of fewer adverse effects. We performed a double-blind, randomized, controlled clinical trial in patients with peripheral vascular disease with lesions appropriate for angioplasty. We compared the efficacy and side effects of two doses of aspirin (50 mg vs. 900 mg daily) during a period of 12 months after angioplasty. A total of 359 patients were evaluated: 175 were randomly assigned to treatment with 900 mg aspirin daily and 184 to 50 mg aspirin daily. Thirty-nine patients developed restenosis at the angioplasty site; the cumulative percentage of event-free survival after 1 year (patency rate) was 85% in 900 mg group and 84% in 50 mg group. An equivalence test showed the two groups equivalent with respect to restenosis rates (P = 0.0003 for an equivalence region of < 10% difference. Nine patients (5%) in the 900 mg group had serious gastrointestinal side effects (peptic ulcer, 8; erosive gastritis requiring transfusion, 1) compared to two ( peptic ulcer) in the 50 mg group (P = 0.03). The results of our study show that a dose of 50 mg aspirin a day is as effective as 900 mg for the prevention of restenoses after lower limb angioplasty, and that severe gastrointestinal side effects are less frequent.

Aged↗
PubMed1993

[Dose-dependent side effects of acetylsalicylic acid therapy. Results of a prospective randomized clinical study in patients with peripheral arterial occlusive disease].

BACKGROUND AND METHODS: In 359 patients with peripheral arterial occlusive disease who had undergone percutaneous transluminal angioplasty (PTA), a randomized double-blind, controlled clinical study was done to investigate the tolerability of acetyl salicylic acid (ASA) given for reocclusion prophylaxis. A comparison was made between a conventional daily dose of 900 mg ASA and a dose of 50 mg ASA. RESULTS: Within an observation period of one year following PTA, 35 patients (20%) in the 900 mg group, and 32 patients (17%) in the 50 mg group left the trial because of side effects (p = NS). Under the higher dose, however, severe gastrointestinal side effects (ulcer, haemorrhagic gastritis requiring transfusion) were significantly more common (nine patients delta 5.1% vs two patients delta 1.1%, respectively; p = 0.03). Overall, 107 patients (30%) reported subjective side effects such as upper abdominal pain, a sensation of fullness or nausea during the course of the trial. 62 of these patients were from the 900 mg group (35%) as compared with 45 patients (24%) in the 50 mg group (p = 0.02). Self-scoring of epigastric pain on the basis of a visual analogue scale revealed a score of 1.3 (95% confidence interval 0.9 to 1.6) in the 900 mg group and 0.8 (95% confidence interval 0.6 to 1.0) in the 50 mg group. The subjective pain intensity showed a uniform time course for all three types of symptom, with a maximum after three months. CONCLUSION: Our results confirm the superior tolerability of the lower dose, in particular in elderly patients. For long-term treatment, the smallest possible effective dose should be chosen.

Aged↗
PubMed1992

[The diagnosis of lymphatic vascular dysplasia and lymphatic fistula formation].

The importance of lymphangiography for diagnosing the formation of lymphatic fistulas and vascular dysplasias of the lymphatic vessels is on the increase within the scope of therapeutic invasiveness. Its importance and ranking in diagnosing lymphatic circular disorders is demonstrated and exemplified by case reports on three patients suffering from chylothorax of various origin, on one patient with chyluria, and one patient with lymphoedema in the soft parts of the neck. In two chylothorax patients, lymphangiography resulted in successful surgery. It is the decisive method in diagnosis and therapy planning in fistulas and dysplasias of the lymphatic vessel system.

Adult↗
PubMed1991

[Phantom studies using echo contrast media to improve the Doppler color sonographic imaging of the superficial femoral artery in the adductor canal].

The adductor canal was simulated using 2.6 cm muscular tissue and 2 fasciae to analyse the limits of colour-coded Doppler sonography (angiodynography) in this region. Defects in the spectral signal cause a significant underestimation of mean, peak systolic and peak diastolic (backflow) velocities and of calculated blood flow. Furthermore the pulsatility index is overestimated and the colour-coded visualisation of the arteries is almost lost. For the most part, these changes can be compensated by administration of a sonographic contrast agent (SH U 454). A minimum of 9 mg microbubbles/ml blood is required. Nevertheless, the adjustment of system controls (e.g. transducer power) becomes more difficult and an ideal setting impossible.

Contrast Media↗
PubMed1990

[A realistic cardiovascular model for evaluating clinical applicability of duplex and color-Doppler equipment].

To evaluate the accuracy and reliability of colour-coded Doppler devices (CCDD) for practical use, a circulatory phantom with in vivo characteristics was developed. The experimental design consists of a piston-diaphragm metering pump with an adjustable piston volume and frequency of stroke as well as silicone tubings with different elasticity and diameters comparable with cadaver arteries. Depending on physiological conditions, blood as a circulating fluid and the surrounding soft tissues of the artery near the Doppler probe should be employed. The transducer should be manually guided. Thus, comparable to physiological frequency spectral displays, different types of wave forms (e.g. monophasic, triphasic) were initiated to analyze the reliability of CCDDs for practical use.

Blood Flow Velocity↗
PubMed1990

[Phantom studies of the value of color-coded Doppler sonography in arterial occlusive disease of the lower extremities].

A new practically orientated phantom for evaluating Doppler Duplex equipment was developed and used to determine the possibilities and limits of color coded Doppler Sonography (Angiodynography) in the diagnosis of arterial occlusive disease of the lower extremity. The problems that may occur in quantifying flow in these arteries are analyzed. The influence of superimposed slices of various soft-tissues on flow quantification, on the spectral waves and on color coded visualisation of the arteries and the possibility to compensate those changes by the use of sonographic contrast agents are discussed.

Arterial Occlusive Diseases↗
PubMed1987

[Hand arteriography. Surgical indications and results].

Based on experience in arteriography of the hand in 108 patients the authors present in a retrospective study the surgical indications (trauma, tumour, angiodysplasia, malformation and embolic lesion) and results of this method. The diagnostic value of arteriography of the hand is shown by means of results and examples.

Angiography↗
PubMed1987

[Results of percutaneous transluminal embolization therapy in severe hemorrhages in the pelvis].

Percutaneous transluminal embolisation technique (PTE) is used to an increasing extent in preference to surgical operations for treatment of severe haemorrhages of surgical, gynaecological, and urological tumours of the pelvic region which are difficult to control. Based on a study of 35 patients (19 female and 16 male) with an average of 71 (32-87) years the indication of embolisation, the technique, the choice of material for embolisation, the rate of success, and the complications of this therapeutic method are discussed. In 34 of the 35 patients bleeding stopped after embolisation therapy. Only in one patient major side effects were seen. Our own experience has shown that an exact pretherapeutic angiogram of the pelvic vessels with selective or subselective catheterisation of tumour feeders is necessary for an effective embolisation.

Adult↗
PubMed1986

[Results of real-time sonography and raster mammography of 200 breast cancers].

The article reports on 200 patients with histologically verified carcinomas of the breast in whom both real time mammasonography and grid mammography were performed. The indications for additional use of real time sonography in the diagnosis of malignant diseases of the female breast were a palpable node or a suspicious finding in mammography. All patients were examined with a high resolution realtime scanner with a 7.5 MHz transducer. The diagnostic criteria of sound deep to the mass (type I-IV), the regularity of the conteur of the mass, and the presence or absence of internal echoes. The typical sonographic features of histologically different types of carcinoma of the female breast are demonstrated by means of case examples. Mammasonography offers a high degree of accuracy in preoperative differential diagnostic assessment of tumour status in malignant processes of the breast. The combined mammographic-sonographic evaluation is the method of choice in clinical evaluation of masses of the female breast.

Adult↗