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Biomedical subjects

H H Woo

Publications and source records attributed to H H Woo.

At least 37 records · Page 2Linked to original sources
PubMed1995

A placebo controlled double blind study using perioperative prazosin in the prevention of urinary retention following inguinal hernia repair.

Acute urinary retention is a frequent complication following inguinal hernia repair. The smooth muscle of the bladder neck and the prostate have been demonstrated to be rich in alpha-1 adrenergic receptors. It has been postulated that the aetiology of acute urinary retention postoperatively is at least partially due to adrenergic stimulation; blocking these receptors may reduce the incidence of acute urinary retention. We have used prazosin in a double blind, placebo controlled study to establish its efficacy in the prevention of acute urinary retention in patients undergoing elective inguinal hernia repair. A total of 70 male patients were enrolled; 36 patients had been allocated active drug and 34 patients had been allocated placebo. Only two patients developed acute urinary retention. Both patients had been allocated prazosin and had received a general anaesthetic for their hernia surgery. In either arm of the study, a higher number of patients developing urinary retention would have been expected but this may be explained by the greater vigilance on urinary output by nursing staff aware that the trial was being conducted. On the basis of our findings, we do not recommend the routine use of perioperative prazosin with inguinal hernia repair. Further studies in high risk groups would be necessary to assess more fully the efficacy of prazosin in this situation.

Acute Disease↗
PubMed1995

Metastatic merkel cell tumour to the bladder.

Merkel cell tumour is becoming increasingly recognized. A case of Merkel cell tumour metastatic to the urinary bladder is presented. The primary site was a cutaneous lesion of the left hand which later metastasized to the axillary and supraclavicular lymph nodes before metastasizing to the bladder. This is believed to be the first reported case of metastatic Merkel cell tumour to the bladder.

Aged↗
PubMed1995

Effects of intravenous thyrotropin-releasing hormone on urethral closure pressure in females with voiding dysfunction.

OBJECTIVE: The aim of this work was to investigate the effects of intravenously administered thyrotropin-releasing hormone (TRH) on the urethral closure pressure in a double-blind, placebo-controlled study. PATIENTS AND METHODS: Sixteen female subjects with either bladder outlet obstruction (BOO) or detrusor underactivity were included in the study. Following randomization, 8 subjects (3 BOO, 5 detrusor underactivity) received 200 micrograms of TRH intravenously, and 8 (4 BOO, 4 detrusor underactivity) received saline (placebo). Standard fluid fill urethral pressure profilometry was performed at baseline and 2, 3, 5, 10, 15, and 20 min following TRH injection, measuring functional profile length (FPL), maximum urethral closure pressure (UCP), and closure pressures at the proximal quarter of the FPL (1/4 UCP) and at the distal quarter of the FPL (3/4 UCP). RESULTS: Significant reductions were found in both FPL (p = 0.022) and 3/4 UCP (p = 0.014) in the 'active' group as compared with the 'placebo' group. CONCLUSIONS: TRH administration significantly reduces the distal urethral closure pressure. Clarification of the mechanism of action of TRH on the urethra may point the way towards new developments in the management of female voiding dysfunction.

Analysis of Variance↗
PubMed1994

Primary structure of the mRNA encoding a 16.5-kDa ubiquitin-conjugating enzyme of Pisum sativum.

The complementary DNA (PsU BC4) representing an mRNA encoding an ubiquitin-conjugating enzyme (UBC) of Pisum sativum has been cloned. The coding region is 444 nucleotides (nt) in length and capable of specifying a 16.5-kDa protein of 148 amino acids (aa) with an isoelectric point of 7.95. The deduced aa sequence showed 97% identity with Arabidopsis thaliana AtUBC8-12 families and tomato ERT17, and 80% identity with yeast ScUBC4 and ScUBC5 and Drosophila melanogaster DmUBC4. The active site cysteine (Cys85) found in UBCs so far described is also conserved in the P. sativum sequence.

Amino Acid Sequence↗
PubMed1994

Renal leiomyoma.

Explore the source record for details and available documents.

Adult↗
PubMed1993

Laparoscopic nephrectomy in the first year of life.

A child was found antenatally to have a cystic right kidney on maternal ultrasound. This was evaluated in the immediate postnatal period with imaging studies and confirmed to be a multicystic, dysplastic kidney. Expectant management was followed; however, the kidney was found to be unchanged in size on a 6-month ultrasound and the parents elected surgical removal rather than continued medical surveillance. A nephrectomy was performed using laparoscopic techniques rather than standard open surgery. Operating time was less than 1 hour. The patient's recovery was unremarkable.

Humans↗
PubMed1991

Frequency of intermediate admissions and place of death of patients with advanced colorectal cancer.

An analysis was made of the place of death and the degree of institutional support required following surgery in patients with colorectal cancer (CRC) who had distant metastases. There was a high incidence of intermediate admissions to an acute hospital, and most patients died in an acute hospital bed. The number of readmissions and the place of death were not influenced by the patients' age, sex, site of tumour or their home situation at the time of diagnosis. In view of the high demand for acute surgical beds, there is a need to develop more appropriate facilities to care for patients in the terminal phase of this disease.

Aged↗
PubMed1985

The postnatal development of retinocollicular projections in normal hamsters and in hamsters following neonatal monocular enucleation: a horseradish peroxidase tracing study.

The pattern of distribution of the retinal projections to the superior colliculus (SC) has been studied in developing normal hamsters and in hamsters following unilateral eye enucleation at birth, using the anterograde horseradish peroxidase (HRP) method. The results show that in normal hamsters the contralateral retinocollicular projection has already reached the caudal pole of the SC on the day of birth, and covered the entire SC by day 1. The ipsilateral retinocollicular projection is distributed only to the rostrolateral portion of the SC on day 0, but has covered the entire area of the SC on day 1. The innervation of the SC by the ipsilateral projection increases gradually until it reaches its maximum density on day 3 or day 4. Beginning on day 6, the density of the ipsilateral projection decreases markedly except in areas where there is a distinct clumping of retinal fibers. The normal adult pattern, which consists of dense clumps of ipsilateral retinal projections in the rostral half of the SC and a sparse ipsilateral retinal projection distributing in almost the entire extent of the SC, is established on day 10. In animals in which one eye was removed on the day of birth, the ipsilateral projection is observed in the rostral two-thirds of the SC on day 1, and innervates the entire extent of the colliculus on day 2. On day 3 or day 4, this projection is denser than that found in normal animals of the same age. The SC remains heavily innervated by ipsilateral fibers on and after day 6. The abnormal adult pattern, which consists of dense ipsilateral retinal projections in most parts of the SC, is observed on day 10. The anomalous ipsilateral retinocollicular projection which develops in eye-enucleated animals suggests that there is a competitive interaction between fibers from the two eyes during development which is critical in shaping the normal adult pattern of the ipsilateral retinocollicular projection. The early development of the contralateral projection is in advance of the ipsilateral projection, and removal of the contralateral fibers by eye enucleation at birth seems to result in a further delay in the development of the ipsilateral projection. This suggests that in the hamster the contralateral fibers may play a role in guiding the ipsilateral fibers to reach their target region.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1984

The normal and abnormal postnatal development of retinogeniculate projections in golden hamsters: an anterograde horseradish peroxidase tracing study.

In adult hamsters, the dorsal lateral geniculate nucleus (LGd), which lacks a noticeable pattern of cellular lamination, receives fibers predominantly from the contralateral eye except for a medial segment which receives fibers from the ipsilateral eye. Using the method of anterograde transport of horseradish peroxidase (HRP), it is shown in this study that the contralateral and ipsilateral retinogeniculate fibers innervate the LGd by day 0 with the development of the contralateral fibers slightly ahead of the ipsilateral ones. The entire contralateral LGd is filled with retinal fibers by day 1. The ipsilateral LGd is almost completely covered with retinal fibers on day 2 but with the fiber density much higher in the dorsal half of the nucleus. Thus, fibers from both eyes overlap with each other completely beginning on day 2 in the LGd. The segregation of these fibers becomes obvious on day 6 as indicated by a decrease in the density of ipsilateral fibers in the ventral portion of the LGd while the ipsilateral projection continues to concentrate in the dorsal half of the nucleus. A low density area in the dorsomedial part of the contralateral LGd is observed on day 7. By day 8, the segregation of the contralateral and ipsilateral projections has achieved an adult-like pattern. Thus, there seems to be two phases for the normal development of the retinogeniculate fibers. In the first phase, axons from both eyes grow in and occupy the entire LGd. In the second phase, those axons occupying inappropriate areas of the LGd are eliminated to form the adult pattern. The effect of unilateral eye removal at birth on the development of the retinogeniculate projection from the remaining eye was also studied with the anterograde HRP method. The ipsilateral fibers in the experimental animals are distributed in the lateral portion of the nucleus in the first two postnatal days. The entire LGd is not filled with ipsilateral fibers until day 4. From day 6 onwards, the ipsilateral fibers are more extensive than those of the normal animals. In addition to a dense projection to the dorsal two-thirds of the LGd, moderate amount of ipsilateral axons can be detected in the remaining ventral portion of the nucleus in day 6 and older experimental animals. The development of the contralateral retinal fibers in the experimental animals is similar to that of the normal from day 1 to day 6, i.e. the entire LGd is densely filled with crossed optic axons.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1979

The sequential development of the higher visual centers in the C.N.S. of the quail.

The development of the optic tectum and the main nuclei of the visual pathways were studied in the quail and correlated with retinal development. The lateral geniculate nuclei began to establish by the 8th day of ineubation and the optic fibre reached the optic tectum by the 10th day, a time when the retina acquired its inner segments. By the 14th day when the retina became fully development, the cytological architecture in the tectum and the appearing of the other visual nuclei were completed.

Animals↗