Biomedical subjects
Publications and source records attributed to H Høyer.
A significant positive correlation between serum zinc and serum alkaline phosphatase levels was demonstrated in four patients suffering from acrodermatitis enterophathica for which they received oral zinc sulphate therapy. In one of the male patients a significant inverse relation between serum zinc and serum copper was found.
The effects of tetracycline on the absorption of orally ingested 65Zn was studied on rats by whole body counting assay. 65Zn was given as a single dose to groups of rats, five in each, which were started on tetracycline. Tetracycline was given in daily doses of 25 mg, 50 mg, 100 mg, and 200 mg for 10 days. From the 6th day of the study, 65Zn retention when plotted against time in a semilog plot, approximated linearity. The net absorption of 65Zn in the various groups was determined by extrapolating to zero time the linear curve segment of individual retention curves. Except for the lowest tetracycline dosage, tetracycline significantly impaired 65Zn absorption. The elimination rate of retained 65Zn from the 6th day was significantly higher in the group receiving 200 mg tetracycline as compared with the control group.
A single oral dose of 65Zn was given to groups of rats, 6 or 7 in each, which were started on phenytoin. The drug was given in daily doses of 10, 50, and 100 mg for 10 days. The retention of 65Zn was followed by a whole body counter, and the net absorption of 65Zn was calculated. All phenytoin doses studied were found to increase zinc absorption significantly.
2 patients with recessive X-linked ichthyosis and steroid sulphatase (STS) deficiency were found to have testis cancer. It is suggested that STS deficiency may predispose both to cryptorchidism and to testis cancer.