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Biomedical subjects

H Hackl

Publications and source records attributed to H Hackl.

At least 55 records · Page 3Linked to original sources
PubMed1979

[Clinical results and hormonal aspects of the treatment of virilizing symptoms in women with cyproterone acetate (author's transl)].

28 cases of moderate to severe hirsutism, two cases of acne and one case of axilary hidrosadenitis were tested continuously on average over 6 months by the daily administration of 100 mg cyproterone acetate. This drug was then given together with 1-2 mg oestradiol valerate over a further 6 month period by reversed sequential therapy. The effect of treatment was judged as being moderate only in 7 cases of idiopathic and one case of adrenal hirsutism and good in the remaining cases. However, this regimen caused a marked lowering of the urinary dehydroepiandrosterone sulphate and low polar oestrogen levels and also the plasma testosterone level. At the same time, according to preliminary results, the fraction of sex hormone binding globulin was raised. The plasma hydrocortisone level was depressed by about 20%. The fractions of 17-KS and 17-KGS decreased slightly at first, but then returned to normal. The side effects of continuous treatment were mainly gestagenic and of reversed sequential therapy mainly oestrogenic in nature. The continuation rate was 81% during a treatment period of two years.

17-Ketosteroids↗
PubMed1977

[The histo-morphologic patterns of cholestatic hepatosis (author's transl)].

Histologic liver examinations performed in 500 autopsies showed 32 times the incidence of cholestatic hepatosis. Males are affected more commonly than females as our statistic indicates. Furthermore it was shown that chronic alcoholism seems to be a more aggravating cause for hepatosis than a long term treatment with psychopharmacologic drugs. No correlation however was found between the extent of cholestasis and morphologic alterations (inflammation, fatty degeneration, iron storage and necrosis).

Alcoholism↗
PubMed1977

[Neurohumoral influences of steroid hormones on sexual responsiveness in women (author's transl)].

An analysis has been carried out on the basis of endocrinological and psychosomatic studies of the influence of steroid hormones, acting via probable transmitter substances, on the sexual response in women. From a review in the literature it can be concluded that among other factors the endocrine state of the women determines her sexual response and behaviour. However, the present lack of specific psychological tests is pointed out, as well as the absence of relevant hormonal data to the sexual sphere, both normal and pathological.

Aging↗
PubMed1975

[Clinical screening of sterility cases for the possible presence of luteal phase defect (author's transl)].

Eighty consecutive cases of sterility was screened for suspected insufficiency of luteal function. The parameters used in the assessment were one value each for pregnandiol and oestrogen excretion, the basal temperature, the histological picture of secretory endometrium, as well as the activity of endometrial malate dehydrogenase and carbonanhydrase, or malate dehydrogenase and succinic dehydrogenase. Histological irregularities, a short luteal phase as indicated by the basal temperature, early abortion and a pregnandiol excretion of less than 1.9 mg were usually accompanied by low endometrial enzymatic acitvity. A comparison of pregnandiol excretion levels with the other four investigated parameters indicated that the number of negative findings increased with decreasing pregnandiol values. In this way, low oestrogen excretion values occurred more frequently with low pregnandiol values. However, when taken in conjunction with other findings, a low oestrogen value does not seem to be characteristic of luteal insufficiency. In certain cases the suspicion of luteal insufficiency increases with decreasing pregnandiol values and with the number of negative findings concerning basal temperature, endometrial histology and enzymatic activity, as well as oestrogen excretion. According to this point of view the incidence of a presumptive luteal phase defect was 33% in the present investigation.

Corpus Luteum↗
PubMed1975

[2 cases of primary sarcoma of the heart].

Two cases of sarcoma of the heart, one of them being a round cell sarcoma, the other a rhabdomyosarcoma with fibrosarcomatous areas, are discussed. Studies of the histologic type, age and sex distribution, localization, general mode of growth and metastatic growth were made by reference to 225 cases reported in the international literature. Pertinent references are obtainable from the authors upon request. Results are presented in diagrams and tables.

Aged↗
PubMed1975

[Some considerations on clear cell tumors, especially in the lungs (author's transl)].

On the basis of 4 cases seen by the author and comparative reports in the literature the following observations were made: 1. Clear cell tumors of the lungs must be considered as semimalignant (or malignana). 2. Malignant degeneration may be associated with a loss of the clear cell character. 3. Clear cell areas are not infrequently seen in common pulmonary carcinomas. 4. Histological differentiation between primary clear cell tumors and metastases (e.g., metastatic hypernephroma) may not be possible. In addition, some general observations on extrapulmonary clear cell tumors will be discussed.

Adenocarcinoma↗
PubMed1973

[Benign lung tumors].

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Adenocarcinoma, Bronchiolo-Alveolar↗