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H Haddad

Publications and source records attributed to H Haddad.

At least 37 records · Page 2Linked to original sources
PubMed1992

Idiopathic ulcerative proctitis may be the initial manifestation of Crohn's disease.

Of 213 patients with proctitis of all etiologies seen between 1977 and 1987, we studied an original cohort of 96 patients with idiopathic ulcerative proctitis (mean follow-up of 62 months). The diagnosis was made according to strict inclusion criteria, and all cases with any initial feature suggestive of Crohn's disease were excluded. Follow-up showed that 13 patients (13.6%) eventually progressed to Crohn's disease, usually within the first 3 years of the initial diagnosis of idiopathic ulcerative proctitis. Their clinical, endoscopic and histological features at initial presentation were indistinguishable from those in whom the diagnosis remained that of idiopathic ulcerative proctitis. In nine of 13 of these patients (70.0%), the clinical course was characterized by a more protracted course and a poorer response to standard treatment. Such features were not found in those in whom the diagnosis of idiopathic ulcerative proctitis was maintained. Clinicians should be aware that Crohn's disease may present initially as apparent idiopathic ulcerative proctitis.

Adolescent↗
PubMed1990

The mid-aortic dysplastic syndrome. Surgical considerations with a 2 to 18 year follow-up and selective histopathological study.

Mild-aortic dysplastic syndrome is usually presented with advanced hypertension in young individuals in association with either weak or absent femoral pulses, due to diffuse narrowing of the aorta in its mid thoraco-abdominal course. There is frequent involvement of visceral arterial branches such as renal and superior mesenteric arteries. Although the disease has been popularised by the appealing name of "abdominal coarctation", the term mid-aortic dysplastic syndrome is more appropriate. In spite of the fact that the syndrome was described almost three decades ago, its exact aetiology remains obscure and pathogenesis speculative. Surgical revascularisation remains the only therapeutic remedy, in dealing with this particular group of young hypertensive patients. The clinical presentation, angiographic assessment and long-term outcome, following reconstruction in 11 patients (mean age 24.4 years) with mid-aortic dysplastic syndrome were evaluated, in an effort to determine the effectiveness of surgery. Late follow-up, slightly exceeding 16 years (mean 5.6 years) has shown normal and relief from hypertension in practically all individuals. Furthermore, in order to elucidate at least some aspects of histopathology, studies were undertaken upon specimens from the aortic wall and the renal, carotid, lumbar and brachial arteries. The results suggested predominantly dysplastic features in the media, intima and particularly along the course of internal lamina. Aortography, using different projections, revealed variable patterns of high mid-aortic stenosis with or without associated renal artery disease. All patients were hypertensive (mean blood pressure 170 mmHg) and co-exist renal artery disease, unilateral in three and bilateral in three cases, was detected.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1987

Effects of the sesquiterpene lactone tetraesters thapsigargicin and thapsigargin, from roots of Thapsia garganica L., on isolated spinach chloroplasts.

The effect of thapsigargicin and thapsigargin, extracted from the roots of Thapsia garganica L., on isolated photosynthetic membranes (thylakoids) and intact chloroplasts from spinach leaves (Spinacia oleracea L.) was investigated. Both sesquiterpene lactone tetraesters impair membranes and organelles in an identical, chlorophyll-dependent manner. In thylakoids these compounds primarily act as inhibitors of photophosphorylation. At lower sesquiterpene lactone tetraester/chlorophyll ratios, cyclic and non-cyclic photophosphorylation, ADP-stimulated electron transport and the photosynthetic control ratio progressively decreased with increasing concentrations of thapsigargicin and thapsigargin, whereas the state 4 electron flow, the coupling efficiency of photophosphorylation, the light-induced proton gradient, and the H+ flux across the membranes remained nearly unaffected. Half-maximal inhibition of photophosphorylation was obtained with 4-5 X 10(-7) moles sesquiterpene lactone tetraesters per mg chlorophyll. At higher sesquiterpene lactone tetraester/chlorophyll ratios, uncoupling of photophosphorylation from electron transport occurred. This was evident from stimulation of the state 4 electron flow, decline in the ADP/2e- ratio, increase in proton permeability and decrease in delta pH, whereas the uncoupled electron transport was only little impaired. In intact chloroplasts inhibition of HCO-3, 3-phosphoglycerate and oxaloacetate reduction by thapsigargicin and thapsigargin was not caused by inactivation of the photochemical reactions of the thylakoid membranes but were rather due to alterations in the permeability properties of the chloroplast envelope. This was concluded from similarities in the kinetics of these reactions. It is suggested that the highly lipid soluble sesquiterpene lactone tetraesters effectively disrupt the lipid-protein associations of biomembranes.

Adenosine Triphosphate↗
PubMed1983

Congenital diaphragm of the duodenum in an adult: a case report.

Chronic duodenal obstruction related to a congenital mucosal diaphragm is a rare anomaly that is difficult to diagnose preoperatively. The authors report the case of a 22-year-old woman with this anomaly. Diagnosis was not established until a second surgical exploration, when the web was found and excised through an anterior duodenotomy. The patient had a gastric atony for 3 weeks after the operation. It was successfully corrected by administering oxytocin.

Adult↗
PubMed1980

Small erythematous mucosal plaques: an endoscopic sign of Crohn's disease.

A non-ulcerated granulomatous lesion of the large bowel mucosa has been found in 11 patients, nine of whom already had or eventually developed classical features of Crohn's disease. These lesions, which are multiple, consist of small well-circumscribed raised erythematous plaques surrounded by normal mucosa. At biopsy there is focal haemorrhage of the lamina propria, rupture of the crypts, release of mucus, and frank granulomatous reaction with giant cell formation. The lesion may be reversible or be followed by the classical mucosal ulcerations. They may occur in the presence or the absence of classical lesions of Crohn's disease elsewhere in the gastrointestinal tract. As this non-ulcerated lesion may occur in isolation, it may provide the initial clue to the diagnosis of Crohn's disease.

Adult↗
PubMed1980

Postoperative gastric mycosis.

Significant symptoms postoperatively may be associated with massive growth of yeast organisms in the gastric remnant. Contrary to reports in the literature, the roentgenologic appearance is suggestive but not diagnostic of the presence of gastric mycosis. In our series, roentgenologic studies, gastroscopy and direct microscopic examination of the gastric contents have been required to establish the diagnosis of gastric mycosis. In our experience, as well as in that of other reported series, gastric mycosis has been most frequently seen following vagotomy and antrectomy with Billroth I reconstruction. The physiopathology is speculative, but abnormal gastric emptying of solids, increased intragastric pH and reflux of duodenal contents into the stomach are strongly suggestive factors. Treatment of this condition, as reported in the literature, has been empiric and not quite successful. Our treatment protocol has given us more satisfactory results. Postoperatively, gastric mycosis is a benign condition not associated with obstruction of the gastric outlet or the intestine, gastric hemorrhage, anemia or peforation. Aggressive treatment is not justified in the absence of severe symptoms. If the reflux of duodenal contents is suspected to be an important contributing factor, reconstruction of the gastric outlet using the Roux-en-Y principle may give gratifying results.

Adolescent↗
PubMed1979

Ischemic colitis associated with hypertension.

A 48-year-old man with accelerated hypertension developed right-sided ischemic colitis. There was no evidence of another cause of vascular inadequacy. Microscopically, the bowel showed ischemic alterations of different stages. The arterial alterations of different stages. The arterial vessels showed minimal changes. In older lesions, fibrosis was prominent and the mucosa was atrophic. In more recent lesions, some vessels of the submucosa were plugged with fibrin and the overlying mucosa was infiltrated by nonorganized hemorrhage and cellular elements.

Arteries↗
PubMed1978

Changing indications for cesarean section. A 38-year experience at a community hospital.

A review of a 38-year experience with cesarean section at a community hospital shows considerable change in both the rate and indication of cesarean sections. A marked increase in the cesarean section rate was noted after 1972. This increase was due primarily to an increase in the primary cesarean section rate for cephalopelvic disproportion and labor abnormalities, fetal distress, and the breech presentation. As a result of this study, we anticipate a primary cesarean section rate of approximately 10%: 3-5% for cephalopelvic disproportion and labor abnormalities, 1-1 1/2% for fetal distress, 3% for breech presentation, and 1-2% for all other indications.

Breech Presentation↗
PubMed1975

Crohn's disease of the vulva.

Three patients with Crohn's disease primarily involving the large intestine had unusual abscesses of the vulvar area. At biopsy, the abscesses had classic features of the primary disease and were clearly separated from the intestinal tract. There was no fistula in the anal canal, and the perineum between the vulvar abscess and the anus was normal. One of the patients also had an early lesion of Crohn's disease in the sigmoid. The lesion appeared as a small erythematous spot without ulceration. Biopsy revealed a typical granuloma under an intact mucosa. It is concluded that Crohn's disease is not confined to the gastrointestinal tract, and that early lesions of the disease within the gastrointestinal tract are submucosal rather than mucosal.

Abscess↗