PubMed Health⌕ Search

Biomedical subjects

H Hainaut

Publications and source records attributed to H Hainaut.

17 recordsLinked to original sources
PubMed1995

Radiation-induced gliosarcoma. Case report and review of the literature.

A 13-year-old boy presented with a cerebral gliosarcoma 12 years after having acute lymphoblastic leukemia treated by chemotherapy and central nervous system prophylaxis treated by radiation therapy (24 Gy) and intrathecal methotrexate. A review of the literature disclosed 129 possible radiation-induced gliomatous and/or sarcomatous brain tumors: namely, 89 gliomas, 36 sarcomas, and four gliosarcomas, including the present case. An analysis of these cases revealed several characteristics that differentiate them from similar spontaneous brain tumors, thus providing arguments for the carcinogenic effect of radiation therapy on intracranial tumors.

Brain Neoplasms↗
PubMed1991

Neuroblastoma in a dwarfed newborn. Possible clue to the chromosomal localization of the gene for achondroplasia?

The authors report a premature achondroplastic child with connatal neuroblastoma. Though this association could be coincidental, we suggest that a microdeletion inducing a contiguous gene syndrome involving the locus of neuroblastoma suppressor gene could be an alternative hypothesis. The gives a working hypothesis for the localization of the gene for achondroplasia.

Achondroplasia↗
PubMed1990

[Pulmonary carcinomatous lymphangitis and renal adenocarcinoma].

The case of a 7 year-old who presented with lymphangitic carcinomatosis revealed by lung biopsy and secondary to renal adenocarcinoma is described. This biopsy was performed because of radiologic and clinical signs associating bilateral interstitial infiltrates, mediastinal adenopathy and gradually increasing respiratory distress. Despite treatment, the child died two weeks later.

Carcinoma, Renal Cell↗
PubMed1987

Treatment of acute lymphoblastic leukemia in children with the BFM protocol. A cooperative pilot study.

From January 1981 through July 1983, 141 children with newly diagnosed acute lymphoblastic leukemia were registered in a cooperative clinical study whose objective was to evaluate the toxicity and the feasibility of the German Berlin-Frankfort-Münster (BFM) protocol. The results were comparable with those reported by the BFM group. For the 133 patients (94%) who achieved complete remission, the actuarial disease-free survival was 67% at 4 years. These results were obtained in spite of a high rate of deaths in complete remission during the initial year of the study. Subsequently, probably as a result of improved expertise in the handling of the protocol, the proportion of toxic deaths declined sharply. Although the current BFM protocol adjusts for aggressiveness of therapy according to the volume of the liver and spleen, splenomegaly (but not hepatomegaly) remained of prognostic significance. Moreover, for patients with bad risk features, an initial high hemoglobin level was found to represent an additional factor of negative significance.

Adolescent↗
PubMed1986

[Primary pulmonary hemangiopericytoma in children. Apropos of a case].

One case of primary pulmonary hemangiopericytoma in a 4 year child is reported; hemangiopericytoma has been found at any age and at any site, however pulmonary location has never been described before in a child under 10 years. Histology, natural history, prognosis and treatment are briefly discussed.

Age Factors↗
PubMed1985

Subacute subdural hematoma as the first symptom in a child with hemophilia A.

The authors reported a case of subacute subdural hematoma in a 14-month-old child suffering from mild hemophilia (Factor VIII, activity: 2.5%). Removal of hematoma under the cover of replacement therapy has been performed safely and has led to recovery without any clinical sequelae. Computerized tomography appeared very useful as an atraumatic method of examination in hemophiliacs. Discussion deals with the problems associated with management of intracranial hemorrhages in hemophiliacs and emphasizes the need of prompt adequate medical and surgical treatment to prevent irreversible damage to the brain.

Brain Damage, Chronic↗