We describe a patient with liver scarring associated with congenital absence of the right lobe of the liver. Computed tomography demonstrated a low density zone at the periphery of the liver that appeared hyperintense on T2-weighted MRI and markedly enhanced on contrast-enhanced T1-weighted imaging. Computed tomography during both arteriography and arterial portography demonstrated a differential blood supply to the low density zone, suggesting the diagnosis of liver scarring. Histological examination of a biopsy from this region disclosed periportal fibrosis and sinusoidal dilatation, confirming the diagnosis of liver scarring.

Female↗

PubMedDate not supplied

The mechanical strength of the growth plate under the influence of sex hormones.

As sex hormones are considered to play a role in the etiology of the slipped upper femoral epiphysis, the influence of sex hormones on the mechanical strength of the epiphyseal plate was investigated in 310 female and 70 male rats. Ovariectomy weakened the strength of the growth plate while orchiectomy strengthened it. Estrogen given after ovariectomy, markedly strengthened the plate. Histologic examination revealed that the width of the growth plate was narrower in the mechanically stronger group. Hydroxyproline content increased and hexosamine content decreased in the epiphyseal plates of the mechanically stronger group. These observations confirm the view that sex hormones, especially estrogen, regulate the mechanical, morphologic, and biochemical functions of the growth plate.

Animals↗