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Biomedical subjects

H Hamilton

Publications and source records attributed to H Hamilton.

53 records · Page 3Linked to original sources
PubMed1985

The effects of serum on the in vitro adherence and maturation of bovine monocytes.

Serum concentration was found to affect both the initial adherence and subsequent in vitro maturation of bovine monocytes. Bovine monocytes cultured in the absence of serum remained small and reduced in number, whereas monocytes cultured in an adequate concentration of either autologous adult bovine or fetal bovine serum developed into large macrophage-like cells. Heat inactivation (56 degrees C for 30 minutes) did not affect the ability of bovine sera to promote monocyte maturation in vitro.

Animals↗
PubMed1985

Development of sign-based perception by deaf children.

In this study the sign-based perceptual abilities of 59 deaf children are investigated. Like many hearing speaking children, deaf signing children appear to perceive isolated lexical items based on the formational parameters of those items. Also, deaf signers show trends similar to those exhibited by hearing speakers for the development of the perceptual ability necessary to distinguish between minimal pairs within their respective language systems.

Child↗
PubMed1978

Health care afloat.

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Delivery of Health Care↗
PubMed1976

Effects of glutamate and sulphur containing amino acids on ammonia toxicity and methionine sulphoximine convulsions in mice.

Arginine and large doses of glutamate (greater than 500 mg/kg) were found to reduce ammonia toxicity transiently in mice. Smaller doses of glutamate (greater than or equal to 200 mg/kg) were effective when administered with glucose. Cysteic acid, homocysteine and methionine, but not taurine reduced ammonia toxicity. All 4 amino acids reduced the number of convulsions induced by methionine sulphoximine. It is proposed that taurine has a general anticonvulsant action and that cysteic acid, homocysteine and methionine may have a specific effect on the action of ammonia on the central nervous system.

Amino Acids, Sulfur↗
PubMed1976

Enhancement of alcohol withdrawal convulsions in mice by haloperidol.

Based on the data presented here and the clinical observations cited it would appear that although haloperidol has been used with a certain degree of success for the treatment of acute alcohol abstinence the authors would like to caution the clinician against widespread use of heloperidol for treatment of alcohol withdrawal. In experimentally induced ethanol withdrawal, chlordiazepoxide appears to be a more effective and safer agent for ameliorating symptoms associated with excitation such as tremor, insomnia, anxiety, and hyperexcitability. A double blind comparative clinical investigation between chlordiazepoxide and haloperidol for treatment of alcohol withdrawal is warranted.

Animals↗
PubMed1975

Crash!

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Aviation↗
PubMedDate not supplied

Assessment of patients requiring i.v. therapy via a central venous route.

In the past, problems associated with the prolonged maintenance of a patient with a central venous catheter (CVC), inserted for the administration of antibiotics, chemotherapy, intravenous (i.v.) fluid replacement of i.v. alimentation, have limited the duration that such catheters can remain in situ. This article highlights the necessity for and increasing importance of accurate patient assessment before catheter insertion for the long-term care and maintenance of individual i.v. devices. CVCs that may once have had a limited lifespan as a result of thrombosis, infection and eventual lack of suitable venous access, are increasingly being maintained in a satisfactory functional condition for long periods, ranging from many months to years.

Catheterization, Central Venous↗
PubMedDate not supplied

A noncomparative study of cefprozil at two dose levels in the treatment of acute uncomplicated bacterial sinusitis.

The efficacy and safety of cefprozil at two dose levels were evaluated in 110 patients with acute uncomplicated bacterial sinusitis in an uncontrolled, noncomparative, Phase II trial. Ninety patients received 250 mg of cefprozil (low-dose group) and 20 patients received 500 mg of cefprozil (high-dose group) every 12 hours for ten days. Evaluable patients had symptoms consistent with acute sinusitis, pathogens isolated at pretreatment susceptible to cefprozil, and a radiograph positive for sinusitis within 48 hours before treatment. A satisfactory clinical response was achieved in 34 of 39 evaluable patients (87%) in the low-dose group and in all 16 evaluable patients (100%) in the high-dose group. Pathogens were eradicated in 35 of 39 patients (90%) in the low-dose group and in 15 of 16 patients (94%) in the high-dose group. A total of 140 of 155 pathogens (90%) isolated pretreatment were susceptible to cefprozil. Six patients (7%) in the low-dose group and one patient (5%) in the high-dose group reported at least one adverse clinical event.

Adolescent↗
PubMedDate not supplied

Central lines inserted by clinical nurse specialists.

Historically, central venous tunnelled lines have been inserted by senior medical officers, usually in the operating theatre under general anaesthetic. This method of line placement is applied to patients requiring lines for total parenteral nutrition (TPN), chemotherapy and long-term antibiotic therapy. Since February, 1991, following extensive training, a clinical nurse specialist (CNS) has taken on this role and has expanded the service to include a central line insertion service (LIS) throughout the Oxfordshire district.

Catheterization, Central Venous↗