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H Harders

Publications and source records attributed to H Harders.

At least 19 recordsLinked to original sources
PubMed1981

[Early course in acute pancreatitis (author's transl)].

In this retrospective study the prognostic significance of 5 laboratory parameters in a low and high range (LDH) greater than or equal to 450 and 600 U/l, calcium less than or equal to 2.2 and 2.0 mmol/l, bloodglucose greater than or equal to 160 and 240 mg/dl, creatinine greater than or equal to 1.5 and 2.0 mg/dl, BUN greater than or equal to 25 and 40 mg/dl) and the patient's age was determined in 298 cases at the first attack of acute pancreatitis. The laboratory parameters were determined on the day of admission. The results presented in this study allow 2 major conclusions: 1. both the low and the high range laboratory parameters are potent indices in predicting a high risk group of patients very early. 2. a higher specificity is achieved by these high range parameters.

Acute Disease↗
PubMed1980

[Urinary copper excretion from rats following administration of aliphatic and alicyclic polyamines (author's transl)].

The cupriuretic effectivity of tetradentate chelating agents was measured in rats and compared with that of D-penicillamine. The applied chelators are aliphatic and alicyclic tetramines and tetramine-analogous substances with two nitrogen-atoms substituted by oxygen. Urine copper excretion was measured during 24 h (and 6 and the following 18 h, respectively) after single and repeated doses over a period of 5 days. The aliphatic tetramines, triethylenetetramine (TETA, TRIEN) and BE 6184, were the most active substances. Simultaneous application of TETA and D-penicillamine does not induce a summation or potentiation of the copper elimination. After s.c. application TETA seems to be three times more effective than orally. The potency of aliphatic and alicyclic tetramines is discussed on the basis of in vitro data.

Animals↗
PubMed1980

[The problem of diagnosis of biliary calculi in acute pancreatitis by means of laboratory methods].

In order to assess the validity of a biochemical prediction of gallstones early in the course of acute pancreatitis by simple biochemical values (SGOT greater than or equal to 60 U/l, bilirubin greater than or equal to 1.6 mg/dl, alkaline phosphatase greater than or equal to 100 U/l) 297 patients with alcoholic, idiopathic and biliary pancreatitis were reinvestigated in a retrospective manner. The present study shows that a valid prediction by these values is not possible since 1) only about 40% of attacks of acute gallstone pancreatitis were associated with elevated SGOT, bilirubin and alkaline phosphatase concentrations and 2) there was a considerable overlap with the other etiological groups especially with idiopathic pancreatitis.

Acute Disease↗
PubMed1975

[Quantitative determination and phenotyping of ceruloplasmin in morbus Wilson (author's transl)].

Sera of 17 patients with Wilson's disease and of 48 relatives were investigated as to a possible correlation between ceruloplasmin phenotypes and Wilson's disease. The control group included 727 healthy subjects. The results of the quantitative determination of ceruloplasmin confirmed the overlapping in the groups of so-called heterozygotes and controls known from the literature. The ceruloplasmin phenotypes in starch gel electrophoresis we observed were of the most common phenotype Cp BB in the patients as well as in the controls. Therefore, patients with Wilson's disease also show the normal Cp-phenotypes.

Adult↗
PubMed1975

[Unusual clinical forms of pseudo-LE syndrome: an induced immune-complex disease? (author's transl)].

Two of nine patients with pseudo-LE syndrome had previously undescribed organ manifestations. In one there was the full-blown picture of cutaneous lupus erythematodes, with renal and CNS involvement, ending fatally. Immunohistologically there was severe vasculitis and nephritis, histologically generalised necrotizing angitis. It is possible that the dramatic clinical picture was due to alpha-methyldopa. In the second case lymphadenopathy with bihilar involvement and splenomegaly predominated. Histologically there was no evidence of Boeck's sarcoid. Further studies revealed systemic involvement with immune-complex nephritis, electron-dense deposits in the glomerular basal membrane, and the typical changes of lupus erythematodes in the marrow. In a third case there were similar changes in kidney and marrow. These findings support the view of an immune-complex disease which can be fatal. An unusual feature in seven of the nine patients was the proven intake of Venopyronum¿ coated tablets in temporal relationship to the manifestation of the disease. It is possible that the described cases of pseudo-LE syndrome were drug-induced. The immunological mechanism of the disease would, in that case, be analogous to penicillamine nephropathy.

Adult↗
PubMed1974

[Panchondritis].

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Arthritis, Rheumatoid↗