PubMed Health⌕ Search

Biomedical subjects

H Hasle

Publications and source records attributed to H Hasle.

69 records · Page 4Linked to original sources
PubMed1991

Childhood conditions and adult height.

Self-reported height and childhood conditions among 1711 Danish male general workers born between 1923 and 1940 were analysed. No significant associations were found between adult height and father's occupation, growing up with both parents, paternal unemployment, sickness among the parents, parents receiving disability pension, economical problems in childhood, area of residence in childhood, and years at school. The study therefore provides no support for the hypothesis that poor childhood conditions are the cause of low adult height in this socially very homogeneous sample.

Body Height↗
PubMed1990

Cerebellar toxicity during cytarabine therapy associated with renal insufficiency.

Acute cerebellar toxicity with ataxia and dysarthria is a well-known side effect during high-dose cytarabine therapy. Dose, age, previous neurological disorders, hepatic dysfunction, and renal insufficiency have been inconsistently reported as risk factors. The present paper presents a patient with renal insufficiency who developed severe cerebellar toxicity following treatment with a dose of cytarabine (8 g/m2 over 5 days) not generally expected to be associated with neurotoxicity. Together with a review of the literature, the present case gives evidence of renal insufficiency as a major risk factor in the development of cerebellar toxicity during cytarabine therapy. Reduced doses of cytarabine should be considered in patients with renal impairment.

Acute Kidney Injury↗
PubMed1990

Psychotropic medication in the elderly. A survey of prescribing and clinical outcome.

Due to the increasing elderly population, an increased number of elderly patients requires treatment for mental and behavioural disorders. There are relatively few clinical studies of the prescribing of psychotropic drugs in patients over 65 years of age. A prospective study was undertaken at three centres caring for the elderly, encompassing patients from general nursing homes and a psychiatric department. Entry of patients into the survey was determined by the clinical decision to prescribe psychotropic medication and an age of 65 years or older. Included in the study were 160 patients. The main reasons for initiating psychotropic medication were indicated, and anamnestic data were collected. Initial and continuing dosages of psychotropic medication were recorded. The clinical condition was assessed at the start of treatment and after four and eight weeks, utilising the Clinical Global Impressions (CGI) scale. The patient's daily activity using an abbreviated Stockton Geriatric Rating Scale (SGRS) was assessed. Side effects were recorded using the UKU Scale. Clinical improvement was seen in about half of the patients with the best effect in patients with mainly psychotic symptoms. Patients with chronic dementia-related problems responded less well. Side effects were few and generally mild. This situation may relate to cautious introduction of the medication and adoption of low-dose regimens. All centres avoided, if possible, psychotropic polypharmacy.

Adjustment Disorders↗
PubMed1989

[Fatal thrombocytopenia triggered by quinidine].

A woman aged 60 years receiving anticoagulation treatment on account of artificial mitral and aortic valve prostheses developed severe thrombocytopenia three weeks after the commencement of quinidine treatment. The results of investigations suggested severe thrombocytopenia precipitated by quinidine. The severe thrombocytopenia persisted despite intensive treatment and the condition ended fatally on account of cerebral haemorrhage. The combination of quinidine and oral anticoagulation treatment is not unusual and it is important to bear in mind that both of these preparations may cause increased haemorrhagic tendencies.

Cerebral Hemorrhage↗
PubMed1989

[Allergy presumed by parents of children in nursery schools and day care in relation to conditions of care].

By means of an interview investigation with the staffs of the 11 nursery schools in the Municipality of Odense and 344 day care homes, information was collected about the number of children who received special diets on account of allergy postulated by the parents or predisposition to allergy. 8% of the children in day care and 10% of the children i nursery schools received special diets on account of presumed allergy. Special diets are often instituted without medically documented indications. In institutions with many children on special diets, this frequently results in dietary changes for all of the children. Nursery schools have only very few possibilities for dietary advice. The dietary efforts are not combined with corresponding efforts in other fields such as tobacco smoking, exposure to carpeting and animals. Placing of children with postulated allergy occurs independently of the presence of carpets, animals and smoke in the day care situation. 40-50% of the children in day care homes are passive smokers.

Child Day Care Centers↗
PubMed1989

[Morbidity among children attending nursery schools].

The object of this investigation was to assess the extent to which absence on account of illness in children attending day-nurseries expressed the total morbidity. In four day-nurseries with a total capacity for 164 children, absence on account of illness and symptoms in the children present were registered over a period of 101 weekdays. Children were absent on 5.8% of the days on account of illness. The commonest causes were epidemic children's diseases, colds, sore throats and pyrexia. More than one third of the children present in the day-nurseries presented sign of illness. The most frequent of these were colds. Children were present in the day-nurseries five times as frequently with at least one symptom than they were absent on account of illness. Absence on account of illness provides an incomplete indication of illness among children attending day-nurseries as absence due to illness only represents a lesser quantitative fraction of the total morbidity among these children.

Child, Preschool↗
PubMed1989

[The significance of childhood conditions with regard to disability pensions. A case-controlled study among unskilled workers].

The significance of the conditions in childhood and adolescence for awarding of disability pension is illustrated by means of a case-control design with persons matched according to age, sex and type of work. The group investigated consisted of 581 general male workers who received middle or highest disability pension and 1,550 control persons. No significant differences were found between the case and control group as regards the occupation of the father, unemployment of the father, illness or disability pension in the parents, economical problems during childhood, growing up in the parental home and growing up in rural or urban surroundings. Disability pensioners had more frequently had schooling for less than seven years. These results cannot confirm the conclusions from previous investigations which are associated with bias in the form of socioeconomical differences between the group investigated and the control group. Unskilled work results in confounding as it is associated not only with poor childhood conditions and also with a high incidence of disability pension. Poor childhood conditions are not found more frequently within the group of general workers among the disability pensioners and can thus not be regarded per se as a risk factor for awarding disability pensioning. However, the childhood condition may influence the choise of occupation and then indirectly act as a risk factor for disability pension.

Adult↗
PubMed1989

[The significance of working conditions with regard to disability pensions. A case-controlled study among unskilled workers].

The incidence of disability pension varies considerably from occupation to occupation. General workers are the occupational group where disability pension is most frequently recognized. In this investigation, the significance of the working conditions for awarding disability pension is illustrated by means of a case-control design. The case group consisted of 581 unskilled workers who received the middle or highest disability pension. The control group consisted of 1,550 age-matched unskilled workers. Disability pensioners had commenced work at a young age significantly more frequently. They had been exposed to physically strenuous work, too rapid a tempo and a long series of unpleasant working conditions. In addition, disability pensioners had frequently experienced periods of unemployment. No differences were observed as regards piece work, shift work or the number of places of employment. The stressing working conditions which occurred more frequently among disability pensioners are all accessible for preventative measures.

Adult↗
PubMed1989

[Consumption of psychopharmaceuticals by residents at nursing homes. Significance of the environment at the nursing home].

The object of the investigation is to describe the consumption of psychopharmaca and hypnotics in nursing homes and, simultaneously, to describe the environment in the nursing homes. Five nursing homes supervised by the same practitioner participated. The medicine consumed by 125 residents was registered. Ninety-two residents were interviewed. Psychopharmaca were administered to 37% of the residents. The consumption varied only slightly between the five nursing homes (from 30% to 42%). The consumption was not associated with proportion of patients who had been referred on account of mental incapacity. Hypnotics in the form of benzodiazepines were employed by 50% of the residents (variations from 36% to 65%). The duration of administration of nocturnal sedatives was, on an average, 21 months. This consumption was not associated with mental incapacity or the duration of the stay in the home. The nursing home environment was assessed by interviews with the residents. Considerable satisfaction was expressed concerning order and organisation and also community spirit. On the other hand, only limited feelings of frankness existed among the residents. Many residents felt more frequently lonely after placement in nursing homes. The two nursing homes where the residents had the greatest feeling of frankness and community spirit had the lowest consumptions of nocturnal sedatives.

Drug Utilization↗
PubMed1988

Differential mortality among semiskilled applicants of disability pension.

The mortality experience among 4,440 applicants for disability pension has been examined during a period of observation of ten years. All applicants were males and had been member of the Danish Semiskilled Workers' Union. The reference group consists of age matched male members of the same union. The applicants for disability pension experienced a considerable excess mortality when compared with the reference group. The higher mortality risk is still present more than ten years after the application has been settled. The persons who were refused disability pension experienced an elevated mortality, too. In opposition to previous studies it is not found informative to put forward a common estimate of the elevated mortality rate because the group of disability applicants is very heterogeneous concerning their mortality experience; the excess mortality is most elevated among persons granted the high level pension, among the youngest, and during the period closest to the award.

Adult↗
PubMedDate not supplied

Effect of various doses of intravenous polyclonal IgG on in vivo levels of 12 pneumococcal antibodies in patients with chronic lymphocytic leukaemia and multiple myeloma.

Polyclonal intravenous IgG (IVIG) was administered as an infusion 6 times every 3 weeks (week 0, 3, 6, 9, 12, 15) in doses of 0.1, 0.4 and 0.8 g/kg BW to determine the dose causing an increase in 12 pneumococcal antibody types above the protective level of 200 ng/ml of antibody N. The dose of 0.4 g/kg BW was found to be optimal in patients with chronic lymphocytic leukaemia (CLL). From the first infusion onwards at least 80% of CLL patients had increases in all 12 antibodies. Five weeks after the last infusion the antibody levels were still elevated in 80% of patients with CLL. The dose of 0.8 g/kg raised all 12 antibodies in 53-73% of CLL patients when assessments were made after each infusion. In multiple myeloma (MM) patients, 73-82% and 73-91% of patients had increased antibody levels, respectively, before and after the 4th-6th infusions at the 0.8 g/kg dose level. However, in only 45-50% of patients did the antibodies remain increased 2 weeks after the treatment at this dose. The dose of 0.4 g/kg caused antibody increases in only 30-50% of patients when measured before the 4th-6th infusion. Serum IgG increased significantly only in the CLL patients, whereas in the MM patients it was high from the beginning owing to the disease. Therefore, the pneumococcal antibody levels were a better marker for the purpose of dose finding. The dosage recommendation in CLL is 0.4 g/kg every 3 weeks until week 12, when steady state is reached. The maintenance dose is 0.4 g/kg every 5 weeks. In MM patients, who have a faster elimination rate of antibodies, the recommended loading dose is 0.8 g/kg, followed by 0.4 g/kg every week as a continuous treatment. Treatment with IVIG in CLL and MM was generally well tolerated. Only 25% of patients experienced minor side-effects, the most frequent being febrile reactions, shivering and headache.

Adult↗