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Biomedical subjects

H Heidrich

Publications and source records attributed to H Heidrich.

At least 19 recordsLinked to original sources
PubMed1992

[Correlation studies of the validity of hemodynamic measuring techniques in peripheral arterial occlusive diseases].

With the aim of validating the methodology employed for Fontaine's classification, haemodynamic correlation investigations were carried out on a group of 35 patients suffering from stage I to IV peripheral arterial occlusive disease and in six healthy patients. These investigations showed that the measurement of tcPO2 at +44 degrees C, capillaroscopy in the foot, measurement of the arterial blood pressure in the ankle by Doppler ultrasound, and measurement of peak flow in the lower limb using venous plethysmography are suitable for distinguishing normal from abnormal blood flow states. A comparison of the various methods made it clear that determination of Fontaine's stages is best achieved by a combination of arterial systolic blood pressure measurement at the ankle with Doppler ultrasound and vital capillaroscopy in the foot. Used alone, vital capillaroscopy, tcPO2 measurement and plethysmography all failed to differentiate Fontaine's stages with adequate reliability.

Adult↗
PubMed1991

[Sonographic diagnosis of deep pelvic/leg venous thrombosis: is color-coded Duplex sonography "superfluous"?].

In the diagnosis of deep vein thrombosis compression B-mode sonography and colour coded Duplex-sonography both are reported to give excellent results in sensitivity and specificity in comparison to phlebography. Therefore value and cost effectiveness of colour coded Duplex-sonography versus compression B-mode sonography are questionable. In our examinations with colour coded Duplex-scanning done one 116 patients in comparison to phlebography we achieved corresponding results to the values of present publications (sensitivity in the leg was 100%, in the calf 89%; specificity in the leg was 94%, in the calf 91%). In earlier examinations with compression B-mode sonography done on 64 patients we were less successful in gaining these results in comparison to phlebography: sensitivity was 76% and specificity was 88% in the iliaco-, femoro-, popliteal region. We discuss the limitations of the compression test in our experiences and point out the advantages of colour coding under special situations.

Adolescent↗
PubMed1991

[Vital findings in capillary microscopy in collagen diseases].

Microangiopathic changes in capillary architecture associated with collagen diseases can be visualized by vital capillary microscopy. In our study of 100 patients with collagen disease we found typical capillaroscopic images in 64%. Differentiation in subclasses showed the highest diagnostic value of this method in systemic sclerosis (77%) and rheumatoid arthritis (68%). It was lower in patients with Sharp- and CREST-syndrome (55%) and very low in systemic lupus erythematosus (33%). In summary, vital capillary microscopy is a valid method in non-invasive diagnostic of collagen diseases.

Adolescent↗
PubMed1991

[Risk-benefit analysis of intra-arterial and intravenous PGE1 infusions in peripheral arterial occlusive disorders].

On the basis of pharmacological and clinical studies this review describes the effects of prostaglandin E1 (PGE1) on the cardiopulmonary system and its profile of adverse reactions taking into account spontaneous reports of side effects. All in all no increased risk of cardiovascular adverse reactions was obvious. PGE1 rather showed some desirable effects on heart and lung. Thus the analysis revealed a positive risk benefit relation for PGE1, provided that dosage and contra-indications are not neglected.

Alprostadil↗
PubMed1991

[Controlled long-term blood pressure measurement with intravenous prostaglandin E1 infusion].

In a placebo-controlled, double-blind study and a follow-up open study with 48 patients between 22 and 87 years of age with peripheral occlusive arterial disease in Fontaine's stage II and IV, the systolic, diastolic and mean pressure and heart rate were studied during intravenous infusion of 40 mcg prostaglandin-E1. This normal therapeutic dose did not have any clinical relevant effect on the blood pressure or cause any significant changes versus placebo in the individual variables measured. Local irritation involving the veins was observed in 6 patients, 1 patient dropped out because of nausea.

Alprostadil↗
PubMed1990

[Raynaud syndrome following timolol-containing eyedrops].

It has been well known for a long time that beta-adrenoreceptor-blocking substances may cause Raynaud's phenomenon in hands and feet if applied orally or parenterally. Nevertheless, vasospastic phenomenons of the "Raynaud"-type have never before been described following local administration. Now a Raynaud's syndrome found in a 58-year old patient, who had been treated for glaucoma with timolol (Chibro-Timoptol-eyedrops), leaves no doubt that there is a risk of systemic vasospasm in ocular application, too. An exposition test was carried out to prove the connection between the application of timolol eyedrops and Raynaud's syndrome. It did reveal that an initially already marginally prolonged warm-up time after exposition to cold water, as measured in the thermographic test, did relevantly get worse after timolol application. At the same time, no change in arterial systolic finger blood pressure could be demonstrated using Doppler sonography. The induction of Raynaud's syndrome by beta-adrenoreceptor-blocking eyedrops may depend on an individual disposition.

Glaucoma↗
PubMed1990

[Contact plate thermography with cold provocation tests for the diagnosis of Raynaud's phenomenon].

Since the contact plate thermography became a serious method to diagnose a vasospasm in form of Raynaud's phenomenon but absolute data for the behavior of the hand temperature under effects of cold were missing, 80 normal persons and 47 patients with a Raynaud's phenomenon were examined to determine the re-warming time after a defined cold exposition and to distinguish normal finger blood flow from pathological. To control the cold exposition of the hands, water immersions with three different temperatures and exposition times were used: 20 degrees C and 3 min., 15 degrees C and 2 min., 10 degrees C and 1 min. The measured re-warming time is the time, in that the thermographical color impression is the same as before the exposition to the cold. Patients with a Raynaud's phenomenon have a significant longer re-warming time than normal persons. The re-warming time of 70-80% of the group of normal persons is 10 min. for the 3 min./20 degrees C test, 15 min. for the 2 min./15 degrees C test and 25 min. for the 1 min./10 degrees C test. These times are a sign for normal behavior; times that lie above these are abnormal and make the diagnosis of a vasospasm reasonable. The diagnosis of a Raynaud's phenomenon is only possible with the typical clinical symptomatic.

Adult↗
PubMed1990

[Mucoid cystic adventitial degeneration of the popliteal artery with simultaneous arteriosclerosis].

A 56-year-old male patient presented with intermittent claudication due to cystic adventitial degeneration of the popliteal artery. In addition independent symptomatic arteriosclerotic alterations of several arteries distal and proximal of the popliteal artery were detected. The etiologic, diagnostic and differential-diagnostic aspects in general and the therapeutic implications of this uncommon case are discussed.

Arterial Occlusive Diseases↗