[Congenital heart defect. Patent ductus arteriosus. Stage: Eisenmenger syndrome (Stage III) with right heart insufficiency].
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Biomedical subjects
Publications and source records attributed to H Hellwig.
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56 patients with deep vein thrombosis (lower limb) and two patients with vena subclavia thrombosis were treated for six hours/day according to an ultrahigh dosage scheme (1,500,000 U/h streptokinase). An average number of three cycles was applied. Complete recanalization could be demonstrated in 23 patients (43%) with lower limb thrombosis, whereas a partial recanalization was demonstrable in 40% (22 patients). A complete thrombolysis could be achieved in one patient with vena subclavia thrombosis. Severe side effects were one intracerebral hemorrhage and one major lung embolism, causing death in both patients. Ultrahigh dosage thrombolysis with streptokinase is an effective therapeutic regimen and is considered to be an alternative to standard fibrinolytic procedures.
Thirteen patients with pericardial abnormalities and a question of constrictive hemodynamics underwent contrast enhanced cardiac computed tomography (CT). Those with clinical and catheterization evidence of restricted cardiac filling demonstrated three CT signs: a dilated IVC, a deformed ventricular contour, and an angulated interventricular septum. Patients with pericardial fluid, thickening, or calcification but without evidence of constriction showed none of these signs. Cardiac CT also defined sites of particular constriction for subsequent resection.
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