PubMed Health⌕ Search

Biomedical subjects

H Henriksen

Publications and source records attributed to H Henriksen.

At least 19 recordsLinked to original sources
PubMed1992

Decay kinetics of O2.- studied by direct spectrophotometry. Interaction with catalytic and non-catalytic substances.

The kinetic behaviour of O2.- during spontaneous dismutation and in the presence of Cu,Zn-superoxide dismutase and other compounds, was studied by monitoring the decrease in absorbance (A250nm-A360nm) on a time-scale of > or = 1 min, at pH 9.5. O2.- was generated from KO2, and calculations were performed between 25 and 4 microM of O2.-. An algorithm for the simultaneous calculation of the 1st and 2nd-order rate constants from the decay curve, was evolved. The respective fractions of O2.- which interacted with catalysts or disappeared spontaneously, in various experimental situations, could be estimated. Substances could be classified as inert, catalysts or scavengers. The high assay pH excluded examination of the effect of alkali sensitive substances, e.g., Mn-superoxide dismutase. However, the high pH minimized the interfering effect of trace amounts of Cu(II). Therefore a metal chelator was superfluous and even the effect of metals and metal complexes could be tested. The extremely high sensitivity of the method allowed minute concentrations of reagents to be used, including proteins absorbing in the UV-region. The rate constants found by this simple method, agreed with those obtained by more sophisticated and inaccessible techniques like pulse radiolysis and stopped-flow spectrophotometry.

Hydrogen-Ion Concentration↗
PubMed1992

[Causes of pain and treatment effect in patients with cancer referred to a multidisciplinary pain clinic].

The causes of pain were analysed in 200 patients referred to a multidisciplinary pain clinic for cancer patients. In 158 patients, pain caused directly by tumour growth was found, 116 patients had pain secondary to the cancer disease or treatment while 33 patients had pain caused by factors unrelated to the cancer disease. The patients had many different combinations of causes of pain and the majority had more than one cause of pain. At the first contact and after treatment for 1-2 weeks, the patients were asked whether they had pain on movement, at rest or pain which interrupted sleep. After treatment for 1-2 weeks and after treatment for more than two weeks, the patients assessed the relief of pain obtained (none, slight, moderate, considerable, complete). The majority of patients achieved relief of pain at rest and during sleep while movement was still accompanied by pain in a number of patients. The majority of patients considered that the relief of pain obtained was moderate or considerable. Treatment consisted of adjustment of medication, blockades and epidural opioids supplemented by psychological intervention and help from social workers in selected patients.

Analgesia↗
PubMed1991

Pain causes in 200 patients referred to a multidisciplinary cancer pain clinic.

Causes of pain were analysed in 200 patients referred to a specialized cancer pain clinic. Pain caused by tumour growth was found in 158 patients, pain secondary to cancer or its treatment in 116 patients and pain unrelated to cancer in 33 patients. Visceral involvement (74 cases), bone metastases (68 cases), soft tissue invasion (56 cases) and nerve/plexus pressure or infiltration (39 cases) were the most frequent causes of pain due to tumour growth. Myogenic pain (68 cases) was the most frequent cause of secondary pain. The patients presented with a multitude of different combinations of causes of pain, the majority having at least two separate causes. Since pain treatment in cancer patients should be determined by its aetiology, a detailed analysis of the pain condition in each patient should form the basis for a rational therapy.

Adolescent↗
PubMed1989

[High-dose epidural opioid treatment of malignant pain].

A retrospective investigation was undertaken of 48 cancer patients receiving long-term treatment with high dosages of epidural opioids. Prior to introduction of the epidural catheter, the patients were in stable oral opioid treatment (median dose: 300 mg morphine/24 hours, range 40-1,360). The effect of stable epidural opioid treatment (median dose: 90 mg morphine/24 hours, range 16-600) in the first catheter was assessed as good in 20, reasonable in 14 and poor in 13. The effect could not be assessed in one patient. Twenty-nine patients could be assessed on pure and stable epidural opioid treatment. The effect was good in 14, reasonable in seven and poor in eight. If the patients were subdivided according to the type of pain, 16 had somatic and/or visceral types of pain while 13 had neurogenic pain. Epidural opioid treatment of neurogenic pain was found to produce statistically significantly poorer results than in the case of somatic/visceral pain (p less than 0.05). At the time of assessment, no statistically significant difference was present in the epidural opioid dosage between the groups. The patients were subdivided into a low dosage group and a high dosage group. The low dosage group comprised patients who had received oral opioid treatment with less than 300 mg morphine/24 hours and the high dosage group comprised patients who received equal or greater than 300 mg morphine/24 hours. Epidural opioid treatment was found to provide statistically significantly better results in the low dosage group (p less than 0.05). In this group, a tendency to better relief of neurogenic pain was observed as compared with the high dosage group. At the time of assessment, no statistically significant difference was present in the epidural opioid dosage between the high dosage and low dosage groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1982

A comparative study of intramuscular buprenorphine and morphine in the treatment of chronic pain of malignant origin.

1 Twenty-seven patients with moderate to severe chronic pain of malignant origin received buprenorphine (0.3 mg) and morphine (10 mg) intramuscularly in a double-blind, single dose within patient study. 2 Efficacy analysis demonstrated no significant differences in the peak analgesic effects or in the time to reach these effects. However, buprenorphine had a significantly longer duration of action than morphine. 3 Sedation was the most frequent unwanted effect with a similar incidence following each treatment. Buprenorphine was associated with a significantly higher incidence, greater severity, earlier onset, and longer duration of dizziness, nausea and vomiting than morphine. 4 Following both treatments there were small but significant decreases in pulse rate, blood pressure, and respiratory rate.

Adult↗