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Biomedical subjects

H Hermes

Publications and source records attributed to H Hermes.

16 recordsLinked to original sources
PubMed1993

Bacterial lysates and ribosomes as inducers of specific immune responses: a comparative study.

A bacterial lysate (OM-85 BV), a preparation of purified bacterial ribosomes (D53) and a placebo were tested for ability to induce the local appearance of specific antibody-containing cells. The three compounds were given orally to 90 children who required tonsillectomy. Surgery was carried out after 1 month of therapy. Frozen-cut sections of each tonsil were tested in indirect immunofluorescence. Cells containing antibodies directed to Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae or Klebsiella pneumoniae were enumerated. Lowest values were noted in the placebo group. Slightly higher numbers were observed after treatment with OM-85 BV, but significant increases were noted only for the elevated numbers of specific antibody-containing cells observed after D53 therapy. Bacterial ribosomal preparations thus contribute efficient induction of specific local immune responses in man.

Adjuvants, Immunologic↗
PubMed1992

[Possibilities and limits of reconstructive surgery of the recurrent laryngeal nerve].

The authors report on possibilities and borderlines of reconstructive microsurgery of the recurrent laryngeal nerve. When paralysis of the vocal cord is proved after thyreoidectomy exploration and control of the nerve should be done immediately. This must be done as fast as possible, latest at the 7th day after thyreoidectomy. If there is found nerve injury caused by intraneural hematoma or compressing sutures microneurosurgical neurolysis and decompression can be done very successful. 8 of 10 neurolysis of the recurrent laryngeal nerve reported by the authors were successful. Because of consecutive autoparalysis nerve suture is possible but not effective.

Follow-Up Studies↗
PubMed1992

[Diagnosis and therapy of thromboses of the internal jugular vein].

The etiology of internal jugular vein thrombosis has changed over to non-inflammatory causes. The advancement in non-invasive diagnostic methods often allows a very early diagnosis. The usual operative therapy is completed by new conservative methods. The authors report about the changed etiology, newer diagnostic methods and actual therapies of the disease.

Diagnosis, Differential↗
PubMed1990

[Early complications following stapedectomy--surgical or conservative treatment?].

The incidence of sensorineural hearing loss after stapedectomy ranges from 0.6% to 5%. There is evidence that reparative granuloma is a major cause: most authors report that it requires urgent surgery, but this view is not universally accepted. This study analyses 14 stapedectomies that resulted in a sudden or gradual sensorineural hearing loss, often combined with vertigo, and presenting between 1 and 6 weeks after an initial hearing improvement. All patients were treated immediately with a combined infusion of an antibiotic, a corticosteroid and a plasma expander. The sensorineural hearing loss began to improve compared with pre-operative values 9 days later. Thus drug therapy might be sufficient in most cases of sensorineural hearing loss early after stapedectomy, and surgery can be restricted to patients with perilymph fistulae.

Adult↗
PubMed1990

[Sialography with digital image processing screens].

We recorded 45 sialograms on digital screens and discuss the use of a digital recording, processing and screening system for the diagnosis of inflammation, tumours and stones of the major salivary glands. Thirty-three investigations of a total of 33 parotid sialograms and 12 submandibular sialograms were analysed. A ductal examination with small volumes of soluble contrast media, permitting painless examination, was possible in all cases due to excellent homogeneous optical density, satisfactory detail and good contrast.

Humans↗
PubMed1989

[Exposure to residues on plant surfaces following the use of plant pesticides in the greenhouse].

Organosphosphorus and carbamate insecticides are quite often used in greenhouses. They represent a group of active principles of toxicological relevance. Initial residues on the surface of cucumber, tomato and ornamental plants, and half-life periods for residue degradation are outlined for carbendazim, dimethoate, fenazox, malathion, methamidophos and pirimiphos-methyl. Residues on plants, concentration in the air, dermal exposition, and inhibition of serum choline esterase activity are shown for methamidophos and aldicarb, respective reentry times being discussed. On harvest and cultivation in greenhouses, dermal exposition as a rule is more relevant than inhalation.

Agricultural Workers' Diseases↗
PubMed1989

[Cochlear implants in patients with radical cavity].

Treatment of patients with severe bilateral hearing loss by cochlear implants usually requires normal temporal bone anatomy. The authors report one case in which the electrophysiological criteria for cochlear implant were fulfilled. However, the patient showed unfavourable anatomy because of a radical mastoid cavity on the suitable side and a congenital anomaly on the opposite side. As a first step the radical cavity was opened from a retroauricular incision and completely de-epithelialized. Thereafter, a retroauricular full-thickness skin flap was formed and rotated into the cavity; the retroauricular incision was not closed. Six months later a cochlear implant (Clark-Nucleus system) was positioned after undermining the flap described above. This surgical technique allows us to provide patients with radical cavities with implants under the usual sterile conditions and avoids contact of the implant with the body surface.

Cochlear Implants↗
PubMed1987

[Therapy of herpes simplex and varicella zoster infections in the ENT area].

The article reports on 41 patients having infections induced by Herpes simplex and Herpes zoster virus. Systemic intravenous administration of acyclovir results in a very rapid reduction of pain and mucosal changes in herpetic stomatitis. In cutaneous lesions of the trigeminal nerve branches induced by Herpes zoster virus there is also a very rapid reduction of pain and efflurescence after 3 days. In 16 patients suffering from Ramsay Hunt syndrome, also known as Herpes zoster oticus, lesions of the facial nerve function were present. 8 Patients demonstrated cochleovestibular signs and symptoms, 2 had flat inner ear hearing loss of 40 dB, 1 reduced unilateral caloric response. Treatment was effected by intravenous administration of acyclovir and simultaneous classical symptomatic therapy consisting of intravenously administered dextrane, cortisone and antiinflammatory drugs. Symptomatic therapy is necessary because acyclovir stops the replication of viruses but does not influence the disturbed nerve function. In 2 cases with a damage of more than 90% of the facial nerve fibres, endaural decompression of the geniculate ganglion was performed. Cochleovestibular deficits improved to normal during one week and all facial lesions within 8 months. Drug-related side effects were seen in one patient who had an exanthema.

Acyclovir↗
PubMed1985

Renal effects of torasemide in the rat. Clearance and micropuncture studies.

The effects of torasemide on renal glomerular and tubular functions were studied in rats using clearance and micropuncture techniques. A dose-response relationship of torasemide in the range of 0.2-20 mg/kg b.w. on the increase of urine volume, urinary sodium and potassium excretion was established. The effect of a dose of 0.2 mg/kg b.w. torasemide was completely abolished by preinjection of 10 mg/kg probenecid, whereas the effects of higher doses remained unchanged. Torasemide had no significant effect on glomerular filtration rate. Proximal fractional reabsorption was not influenced. A remarkable depression of fluid and electrolyte reabsorption, however, occurred in the loop of Henle after torasemide under free flow conditions, as well as in functionally isolated microperfused loops of Henle. No further inhibition of fluid and electrolyte reabsorption between the early distal convoluted tubules and the final urine could be detected. In contrast, a compensatory increase of reabsorption was observed in this part of the nephron. The activity of the tubuloglomerular feedback system was completely and reversibly blocked by torasemide. Torasemide did not differ from other typical loop diuretics with respect to the different renal actions studied here.

Animals↗
PubMedDate not supplied

Computed tomography and magnetic resonance imaging in the preoperative work-up for cochlear implantation.

The role of CT and MRI in the evaluation of patients for possible insertion of a multichannel intracochlear hearing device was appraised. The study included 52 patients who underwent both CT and MRI examinations, 40 of whom were later operated on. Coronal and axial T2-weighted spin-echo sequences were performed in 25 volunteers with normal hearing and in 47 adult patients. In 5 patients, instead of a T2-weighted spin-echo sequence, a T2*-weighted gradient echo 3D sequence with axial presaturation was used. In 39 patients with normal appearances on CT and MRI, the implant device was successfully inserted. One patient who underwent surgery had a reduced cochlear signal on MRI but a normal CT scan; however, at surgery, the implant device could only be inserted into the first turn of the cochlea, due to fibrous obliteration. In 3 of 12 patients who were not operated upon, the results of diagnostic imaging indicated that the insertion of an intracochlear hearing device was not useful. Our experience indicates that, with reduced cochlear fluid signal intensities on MRI, fibrous obliteration of the cochlear turns is likely to be present. MRI proved to be a useful adjunct to CT, but the latter was necessary for the evaluation of bony abnormalities. Gradient echo sequences can successfully replace time-consuming T2-weighted spin-echo sequences.

Adolescent↗