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H Hesse

Publications and source records attributed to H Hesse.

At least 37 records · Page 2Linked to original sources
PubMed1995

Early malnutrition followed by nutritional restoration lowers the conduction velocity and excitability of the corticospinal tract.

The physiological sequelae of undernutrition were investigated in rats that were undernourished from day 1-21 and subsequently free-fed to 75 days of age. Population responses were recorded in the corticospinal tract following surface stimulation of the motor cortex, which activates corticospinal cells directly, and also indirectly via cortical synapses. The conduction velocity of the fastest corticospinal fibers in 15 malnourished rats was 16.9 m/s, significantly slower (P < 0.001) than the 20.0 m/s observed in 26 controls. In addition, the excitability of corticospinal neurons to direct stimulation was reduced as much as 67% in malnourished rats, while no effect on synaptic activation was observed. Our findings suggest that early malnutrition reduces the number of large fibers in the adult corticospinal tract. These results are discussed with respect to known morphological and behavioral effects of malnutrition in rats and their relevance to humans.

Analysis of Variance↗
PubMed1995

"Human pancreas-specific protein" (procarboxypeptidase B): a valuable marker in pancreatitis?

Human pancreas-specific protein (PASP) has been characterized previously as a serum marker for pancreatitis. It was then identified as pancreatic procarboxypeptidase B (PCB). The aim of the present study was to verify the usefulness of PASP (PCB) as a serum marker in patients with acute (n = 20) and chronic (n = 12) pancreatitis and in those following endoscopic retrograde cholangiopancreaticography (ERCP) (n = 44). Serum PASP values were analyzed by radioimmunoassay, with a range of normal values between 15 and 111 ng/ml. Between April 1992 and September 1992, 20 subjects (19-86 years of age) with acute pancreatitis (alcoholic, 8; biliary, 8; other, 4) were studied. We found edematous pancreatitis in 17 cases and severe hemorrhagic pancreatitis in three cases. At admission, peak levels of PASP (average value, 1,976 +/- 329 ng/ml), pancreatic isoamylase (942 +/- 151 U/L) and lipase (2,946 +/- 534 U/L) were detected in 15 of 20, 16 of 20, and 12 of 20 cases, respectively. The etiology of the pancreatitis had no influence on the PASP values. Furthermore, 10 patients with alcoholic and two patients with nonalcoholic chronic pancreatitis (29-67 years of age) were studied. The average peak level of PASP was 1,229 +/- 434 ng/ml. In this group, PASP paralleled the time course of amylase and lipase. Maximal PASP, amylase, and lipase levels were found in 11 of 12, nine of 12, and five of 12 patients, respectively, on the day of admission. ERCP was performed in 44 patients (36-87 years of age), demonstrating common bile duct stones in 16 and bile or pancreatic ductal tumors in 15 cases.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗
PubMed1993

Glucocorticoid receptor binding site in the mouse alpha-amylase 2 gene mediates response to the hormone.

Amylase gene expression has been shown to be positively regulated by glucocorticoids. Previous reports have suggested that this effect is indirect. We have addressed this question in a mouse exocrine pancreas cell line, 266-6, in which basal level of expression of amylase mRNA is low but inducible by glucocorticoids. In these cells the effect of glucocorticoids is not inhibited by cycloheximide at early time points. Reporter plasmids containing 224 base pairs of mouse amylase 5'-flanking DNA are positively regulated by glucocorticoids in gene transfer experiments. Glucocorticoid receptor purified from rat liver binds to the amylase promoter from position -56 to -33 and at the start of transcription. Site-directed mutation at the upstream position (-47 to -42) eliminates response to glucocorticoids in transient gene transfer experiments. Thus, glucocorticoid regulation of the mouse amylase gene is a direct effect and is mediated via a receptor binding site in the promoter region of the gene. Inhibition of the hormone response by cycloheximide at later time points after induction suggests the additional requirement for a short-lived factor. The DNA binding domain of the glucocorticoid receptor binds to a single site in the amylase promoter as a monomer, suggesting that both receptor binding sites as well as an additional short-lived factor are required to obtain induction.

Animals↗
PubMed1990

[Metastasis in lung and pleura].

The Topography, extent and histopathology of lung and pleural metastases in 132 surgical resections were investigated with regard to primary tumours. The emphasis was on postmortaly obtained angiographic results of the neovascularisation of metastases, mainly by vessels of the functional pulmonary circulation with diameters of 20-60 microns. Different phases of metastatic spread were considered such as invasion, embolisation and implantation. The pathologic-anatomic investigation of metastases is becoming more and more important for morphological quantification of tumour regression following cytostatic therapy and for clarifying unknown primary tumours by the immunohistochemical examination of lung metastases.

Humans↗
PubMed1989

[Spontaneous rupture of the spleen in infectious mononucleosis].

Rupture of the spleen occurred in two patients (a man of 32 and a girl of 16 years) with serologically proven infectious mononucleosis. No history of trauma as a cause of the rupture could be elicited in either patient, despite intensive questioning. Abdominal symptoms were left-sided upper abdominal pain radiating into the left shoulder (Kehr's sign). The suspected diagnosis was confirmed by ultrasound demonstration of free abdominal fluid and abnormal splenic structure. Splenectomy had to be performed in both patients.

Adolescent↗
PubMed1981

[Method of photometric measurement of ciliary beat frequency from human tracheobronchial epithelium (author's transl)].

A method of photometric measurement of ciliary beat frequency is described. Brush biopsies of human bronchial epithelium were obtained. Twenty healthy persons were investigated, sampling brush biopsies from trachea, main bronchus and segmental bronchus. Ciliary beat frequency was measured over a period of time at 37 degrees C as well as under increasing temperature from 20 degrees C to 40 degrees C. Mean ciliary beat frequency in the trachea is 12.5 Hz +/- 2.8 at 37 degrees C, slightly increasing ciliary beat frequency towards the periphery of the bronchial tree. Ciliary beat frequency found at 20 degrees C is almost exactly half the frequency found at 37 degrees C. When rising the temperature from 30 degrees C to 40 degrees C, ciliary beat frequency increases nearly in a linear line. A well reproducible method is used to measure ciliary beat frequency in vitro under different conditions.

Adult↗
PubMed1981

Ciliary beat frequency of biopsy samples taken from normal persons and patients with various lung diseases.

Ciliary beat frequency from human tracheobronchial mucosa was measured in vitro. Biopsy samples were taken during bronchoscopy and beat frequency measured with a phase contrast microscope and a photosensitive cell. In 20 healthy volunteers the mean ciliary beat frequency in the trachea was 12.5 +/- 2.8 Hz at 37 degrees C with a wide interindividual range (4.9 to 17.4 Hz), but a good intraindividual reproducibility (+/- 7 percent). There was a slight increase in frequency down the tracheobronchial tree and a decrease at lower temperatures. With some exceptions, no disease-specific correlation in beat frequency seems to exist in different bacterial and malignant bronchopulmonary conditions. However the quantity and quality of ciliated cells brushed from the mucosa does appear to be disease-related.

Adult↗
PubMed1981

Influence of reproterol on ciliary beat frequency of human bronchial epithelium in vitro.

With a recently developed method it is possible to measure ciliary beat frequency of human bronchial epithelium in vitro. By means of brush biopsy, mucosa is taken from a region of the tracheo-bronchial tree and is then put into nutrient solution. Action of the cilia can be observed under a phase contrast microscope and is transferred by a photocell onto an oscillograph. The study was performed in 15 patients; mucosal samples were taken from both the trachea and the main bronchus. It proved that the beat frequency of cilia obtained from both the trachea and the main bronchus was significantly increased by 7-[3-(beta, 3,5-trihydroxyphenethylamino)-propyl]-theophylline (reproterol, Bronchospasmin), as compared to those samples without reproterol.

Bronchi↗
PubMedDate not supplied

Management of immediate occlusion after carotid-reconstruction.

In spite of clear cut indications for surgery and the use of standardized techniques, operative failures are still to be found in carotid surgery, that is, the occurrence or aggravation of neurologic symptoms in connection with surgical reconstruction. These can present when the patient regains consciousness or develop from hours to days postoperatively. Within 3 1/2 years 93 carotid artery operations were performed in 79 patients. The purpose of our presentation is to describe 5 patients who developed neurologic deficits after a successful carotid reconstructive procedure within 18 hours to 10 days postoperatively. These patients were immediately returned to the operation room and reoperated upon. In 4 of 5 cases we achieved a complete recovery. Even though our patient content is small we want to point out that in patients who develop neurological deficits postoperatively after successful surgical procedures an immediate reoperation is mandatory, and may be completely successful. In almost all patients with recurrent neurological deficits after primarily successful reconstructions we carried out control angiograms. We want to emphasize that these procedures are not obligatory since the cause for reoperation is nearly always technical and will require operative revision.

Adult↗