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Biomedical subjects

H Hinkers

Publications and source records attributed to H Hinkers.

5 recordsLinked to original sources
PubMed2002

Chemical and biochemical microsensors in silicon for the clinical on-line monitoring.

Miniaturised chemosensors and biosensors for applications in clinical diagnostics and biomedical fields can be fabricated in silicon with high reproducibility using the containment technology. They are characterised by excellent durability of the sensitive membranes. Meanwhile, there are sensors available for a variety of relevant medically parameters such as pH, the blood electrolytes sodium, calcium, potassium, and the blood metabolites glucose and lactate. The miniaturised sensors provide the opportunity to develop product solutions with minimal sampling volume requirements for the "Point of Care (POC)" sector through the combination of innovative microtechnical components. Two examples are presented, such microsystems have been implemented for the medical applications of "Blood Monitoring" and "Glucose Monitoring".

Blood Chemical Analysis↗
PubMed2000

Miniaturized real-time monitoring system for L-lactate and glucose using microfabricated multi-enzyme sensors.

A miniaturized on-line monitoring system for the detection of L-lactate and glucose is presented. The system is based on a microfabricated multi-enzyme silicon sensor chip with flow channels integrated on the chip. The sensors were fabricated in containment technology. They were characterized in test solutions. The cross-talking behaviour was investigated and was found to be practically negligible. The linear measurement ranges of both glucose and lactate sensors were large enough for most practical applications. As a result of the miniaturization the analyte consumption could be reduced to a few nmol min(-1). The system was equipped with a microdialysis probe whose recovery was 45% for lactate and 37% for glucose in test solutions using a flow rate of 3 microl min(-1). Lower flow rates of 0.5 microl min(-1) resulted in recoveries of over 90%. The long-term stability of the system was acceptable. Initial measurements have also been performed in vitro using human blood serum.

Biosensing Techniques↗
PubMed1999

Containment sensors for the determination of L-lactate and glucose.

This paper reports some new results on enzyme based silicon containment sensors. For the first time an L-lactate sensor in containment technology is presented. Through optimization of the buffer system the stability of the lactate sensor was enhanced and the linear response of over 10 mM was achieved. The glucose sensor has also been optimized for a large linear measurement range exceeding 30 mM. A two-enzyme chip with glucose and lactate sensor elements which were integrated on one silicon chip is presented. The response behaviour of the two-enzyme chip was very similar to the single chip behaviour. No cross-talking effects could be observed. A fabrication process for mass-production is described.

Biosensing Techniques↗
PubMed1994

Glucose sensor in containment technology.

A new transducer concept for miniaturized immobilized enzyme glucose sensors is presented. The enzyme containing membrane is anchored inside the microcontainment of a silicon chip together with the metal electrode. Containment based sensors are ideally suited for integration into microsystems. The fabrication process is planned as a full wafer process allowing transfer to low-cost mass-production with a narrow variability. The functionality of the containment concept is demonstrated by the fabrication of chips with single GOD-based amperometric glucose sensors which have been tested in glucose solution. The advantages of the containment technology are discussed.

Biosensing Techniques↗