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Biomedical subjects

H Hirotani

Publications and source records attributed to H Hirotani.

At least 19 recordsLinked to original sources
PubMed1991

Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols.

The antiviral extract from Rhodopseudomonas capsulata was purified and the predominant active component was defined as cis-vaccenic acid (Cl-8:1 delta 11) by gas-liquid chromatography and gas chromatography-mass spectrometry analyses. Antiviral activities of unsaturated fatty acids and related alcohols against T5 phage were also tested. Among them, linoelaidic acid, oleic acid, and petroselenyl alcohol inactivated 98%, 53%, 67% of T5 phage at the concentration of 50 micrograms/ml, respectively.

Alcohols↗
PubMed1979

Fractures in patients with myopathies.

During the past 4 years, 15 fractures in 10 patients were encountered among 48 hospitalized patients with myopathies. The dominant sites were the femur (supracondylar) and humerus (subcapital). By assessing the total body potassium volume, bone mineral content, serum calcium, inorganic phosphorus, 25-OH vitamin D3, parathyroid hormone, and calcitonin, it is concluded that the proclivity to fracture in myopathic patients is caused by bone atrophy due to a lack of muscle tension related to decrease in muscle volume.

Adolescent↗
PubMed1976

The fate of the articular cartilage in intracapsular fracture of the femoral neck (articular cartilage in femoral neck fracture).

The fate of the articular cartilage of the hip joint with intracapsular neck fracture was studied by histological, histochemical and autoradiographic techniques and by using a polarized microscope and a scanning electron microscope. Cartilage specimens from 93 femoral heads and 7 acetabula were obtained from fractured hips 2 days to 4 1/3 years postfracture and from control hips with various disorders. The cartilage degeneration appeared 2 weeks after fracture and advanced steadily with time. The matrix was covered, invaded and ultimately replaced by the fibrous tissue. Chondrocyte viability, though it was lost from the surface, was recognized in the deep matrix even in the oldest fracture examined. It is concluded that the humoral factor directly caused by the injury as well as the biomechanical impairment, i.e. a loss of physical stress, may play an essential role in the pathogenesis of the degeneration. The possibility of regeneration was discussed.

Acetabulum↗
PubMed1976

Peripheral nerve repairs by the funicular suture technique.

Sixty-one peripheral nerve repairs in 48 patients sutured by the funicular suture technique were followed up for a minimum of 2 years after operation, the average follow-up period being 48 months. Useful recovery was obtained in 100 per cent of cases with radial and musculocutaneous nerve repairs. Seventy-five per cent of cases with median, 82 per cent with ulnar and 88 per cent with digital nerve lesions attained "useful" grade recovery. In the lower extremity, the motor recovery was excellent, whereas the sensory recovery was poor. In two out of three cases where cable grafting was performed between important funiculi the result obtained was excellent. To obtain satisfactory neurological recovery, the funicular suture, technique using the surgical microscope is the method of choice for primary and secondary nerve suture and cable grafting.

Adolescent↗
PubMed1975

Chondrocyte mitosis in the articular cartilage of femoral heads with various diseases.

Autoradiographic studies using thymidine-3H reveal the mitosis of chondrocytes in degenerated joints, i.e. joints having secondary osteoarthritis or aseptic necrosis of the femoral head. The findings obtained provide additional support for the recent investigations regarding chondrocyte mitosis in primary osteoarthritic cartilage. Histologic and histochemical examinations suggest that a loss of glycosaminoglycans in the matrix is evidence for conversion of chondrocyte activity to mitosis which occurs, however, within the limit of "the point of irreversibility", analogous to the observations from the biochemical point of view. Biomechanical and nutritional factors are also discussed in relation to the results obtained from cartilages of the femoral heads in cases of femoral neck fracture and aseptic necrosis of the femoral head.

Cartilage, Articular↗
PubMed1975

Scanning electron microscopy of the articular surfaces of the hip joint disorders.

The specimens from 19 femoral heads with various abnormalities are observed with scanning electron microscopy, comparing with light microscopic findings. Villi and plica appearance implies the fibrillated surface of degenerated cartilage with fibrous tissue proliferation. Beside these findings, craters with their associated undulations of concentric circles or guitar-shaped figures are visualized in the areas histologically showing the exposed cartilage of the deep zone. The undulations are correspondent to the fine clefts of the shredding surface. From the observations reported here, the existence of the lamellar system around the chondrocyte lacuna is proposed in the deep matrix of the articular cartilage.

Aged↗