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Biomedical subjects

H Hoffmeister

Publications and source records attributed to H Hoffmeister.

At least 19 recordsLinked to original sources

Physical activity and its association with cardiovascular risk factors and mortality.

We compared various indices for physical activity and their association with cardiovascular risk factors as well as total and cardiovascular disease mortality. We used data from three independent national representative samples in Germany, with a total of 7,689 men and 7,747 women age 25-69 years. Persons with high conditioning physical activity had more favorable risk factor levels compared with sedentary persons, after adjustment for age, body mass index, smoking, survey period, and socioeconomic status. We observed a clear association with mortality only for intense physical activity. The rate ratio (RR) for total mortality was 0.36 [95% confidence interval (CI) = 0.16-0.79] and 0.26 (95% CI = 0.08-0.83) for cardiovascular disease mortality for men spending more than 2 hours per week on sports, compared with sedentary men. Among women, the corresponding RR for total mortality was 0.28 (95% CI = 0.07-1.17). The effect of physical activity on cardiovascular disease mortality among women was not clear owing to few fatal cardiovascular events.

Adult

Trend of cardiovascular risk factors in the East German population 1968-1992.

The deteriorating trend of life expectance since the mid 1970s, mainly due to higher cardiovascular mortality in the East compared to West Germany, requires explanations about what happened to the cardiovascular risk factor profile in the East. Epidemiologic studies in the East German population have been performed for about 25 years and can justify a first answer to the question, whether the opening gap in life expectancy could be attributable to a deteriorating cardiovascular risk factor profile of the 25-64 year old population. During a review process reliable epidemiological studies in the East German population have been identified to describe sequential changes from 1968 to 1992 in systolic and diastolic blood pressure (SBP, DBP) total cholesterol (CHOL), body mass index (BMI) and cigarette smoking in five periods of time. The mean SBP increased in males of higher age groups, whereas it dropped in females in all age groups in this period of time. The mean CHOL showed a striking increase in both sexes and levelled off in the mid 1980s only. The mean BMI increased slightly in men of the middle age groups and remained almost unchanged in women. The prevalence of cigarette smoking increased in both sexes until the 1970s, and declined thereafter in the age groups over 40, however, there is an increasing tendency in young age groups and females after the wall came down. These trends are congruent with the hypothesis, that the increasingly unfavourable trend of life expectancy in East Germany (compared to the continuously improving trend in West Germany) is at least partly attributable to the trend of the cardiovascular risk factor profile.

Adult

National trends in risk factors for cardiovascular disease in Germany.

BACKGROUND: National representative health surveys for Germany were conducted for the first time in 1984/85 and again in 1987/88 and 1990/91. METHODS: Data from these three independent population samples (ages 25-69 years) are used to describe national trends in cardiovascular risk factors. In addition, national cardiovascular disease mortality rates during this time period are presented. RESULTS: A net rise in median total serum cholesterol level of 0.17 mmol/liter (6.6 mg/dl) for men and 0.08 mmol/liter (3.1 mg/dl) for women was observed. Also observed was an increase in high-density lipoprotein (HDL) cholesterol of 0.04 mmol/liter (1.5 mg/dl) for men and of 0.09 mmol/liter (3.5 mg/dl) for women. This resulted in a favorable increase in the HDL/total cholesterol quotient. There were no statistically significant changes in systolic and diastolic blood pressure, with the exception of a net increase of 2 mm Hg in systolic blood pressure for women. A net rise of 0.3 kg/m2 for men and 0.4 kg/m2 for women in body mass index was observed. The prevalence of male smokers declined during the observed period while the prevalence of female smokers increased. CONCLUSIONS: Most of the measured risk factors increased in both sexes during the study period. This is not reflected in cardiovascular mortality, which has shown a steady downward trend for more than 20 years.

Adult

The relationship between coffee consumption and serum cholesterol under consideration of smoking history.

A large German population sample of 6820 men and 7258 women was used to investigate the relationship between coffee consumption, total serum cholesterol and HDL cholesterol. Analyses were conducted on men and women separately. Differences in age, body mass index, diastolic blood pressure, smoking habits, alcohol, fish, milk and tea consumption, physical activity and medication use were controlled for in the analyses. Interactions between coffee consumption and smoking habits in their relationship with serum cholesterol were part of the analyses. For men, a positive relationship between coffee consumption and total serum cholesterol was found among smokers and life-long abstainers but not in the group of ex-smokers. In women a relationship between coffee consumption and total serum cholesterol was also present, but very weak (only statistical significant in covariance analyses). Levels of HDL cholesterol did not correlate with coffee consumption in either men and women. Hypotheses concerning the peculiarities of the group of ex-smokers are developed, and supporting empirical evidence is given. It is suggested that the group of ex-smokers should always be analysed separately.

Adult

Consequences of current lipid guidelines for the Federal Republic of Germany.

According to the results of the first nationally representative population study in the Federal Republic of Germany (FRG) conducted in 1984-1986, a vast majority of the population have elevated cholesterol levels and undesirable low density lipoprotein (LDL) cholesterol levels. This problem increases with age in two dimensions, more individuals become hyperlipemic and those who were hyperlipemic develop more extreme pathologic values. Preliminary analyses suggest that the national profile in the FRG is worse than that of the USA. Based on the current recommendations of the national cholesterol education program of the USA, 23 million adults in the FRG should be receiving dietary advice for elevated lipid levels and 18 million persons should be in regular treatment programs. Consequently, implementation of such a national strategy and program would require the assembly and training of an adequate professional body of physicians and support staff in the diagnosis and treatment of hyperlipidemias.

Adult

Replacement estrogen use and body mass index.

Peripheral fat is a major source of endogenous estrogens in menopausal women. To investigate whether obesity affects use of replacement estrogens in postmenopausal women, we examined the relation between body mass index and use of replacement estrogens in data from Group Health Cooperative of Puget Sound, the German Cardiovascular Prevention Study, and the Cancer and Steroid Hormone (CASH) study. In each data set, there was a major decline in replacement estrogen use with higher body mass index. All data sets showed hysterectomy to be a strong predictor of replacement estrogen use. Smoking, past use of oral contraceptives and other estrogens, and ages at menarche and menopause did not appear to influence the body mass-estrogen relation. The strong and consistent association between body mass index and use of replacement estrogens in data collected at different times and in different places by different methodologies strongly suggests a common underlying biologic mechanism.

Adult

Patterns of physical activity among German adolescents: the Berlin-Bremen Study.

Patterns of leisure-time physical activity among 932 West German boys and girls from two distinct socioeconomic groups were examined longitudinally over a 2-year period beginning with seventh to eighth grade students. Activity indices reflect the weekly time spent in activities, the weekly frequency of participation, and the average duration per activity episode. The indices refer to all activities, to moderate or vigorous activities, or to each individual activity. The average seventh to eighth grade student spent 10.1 hr/week engaged in all of the activities measured. Overall, the time devoted to these activities declined by 10% during the 2-year study period, with the relative decrease being larger for vigorous than for moderate activities. The decline in time spent in vigorous activity was due to a decreased frequency of participation; whereas the decline in moderate activity was primarily attributable to the decreased average duration per episode. Boys spent about 3 hr/week more in all activities than girls, with the difference largely being due to the boys' greater participation in vigorous activities. Weekly activity time among girls did not vary substantially with socioeconomic status. However, compared with boys of higher socioeconomic status, boys in the lower socioeconomic grouping were 2-3 hr/wk more active because they devoted more time to moderate activities. The results indicate that the identified activity patterns in the population strongly depend on the activity dimensions on which the measure focuses.

Adolescent