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Biomedical subjects

H Holtz

Publications and source records attributed to H Holtz.

At least 19 recordsLinked to original sources
PubMed1992

Increase in plasma total and lipoprotein cholesterol during incubation of whole blood samples at 37 degrees C--influence of LCAT inhibitors.

Incubation of whole blood samples at 37 degrees C caused a time-dependent increase in plasma cholesterol concentrations. In samples from 40 fasting healthy males, plasma cholesterol rose by 13.6 +/- 3% during 24 h (P less than 0.001). Changes in cholesterol concentrations were found in both the HDL fraction and the VLDL/LDL fraction. The increase in lipoprotein cholesterol concentrations correlated positively with the initial levels of HDL cholesterol and apo A-I; and with the original levels of VLDL/LDL cholesterol, apo B and triglycerides. The increase in plasma total cholesterol was not related to the HDL cholesterol and apo A-I concentrations. It was more pronounced in samples with elevated plasma concentrations of total cholesterol, VLDL/LDL cholesterol, apo B and triglycerides. The elevation in plasma total cholesterol resulted from an increase in cholesteryl esters, whereas free cholesterol decreased. After LCAT inhibition no changes in total, free and esterified cholesterol were observed. Therefore, increase in plasma cholesterol seems to represent a LCAT-dependent cholesterol transport out of blood cells.

Adult↗
PubMed1992

Comparison of food intakes of selected populations in former East and West Germany: results from the MONICA Projects Erfurt and Augsburg.

The intakes of selected food groups in former East and West Germany were compared, based on data from the dietary surveys of the MONICA project Erfurt 1987 and of the MONICA project Augsburg 1984/85. Three-day records from 132 middle-aged men from the city of Erfurt (response 73%) and 3-day records from 424 middle-aged men from the city of Augsburg (response 70%) could be included in the comparison. The differences in the consumption of animal products were rather small. The intake of bread and baked goods, potatoes and cooked vegetables was higher in Erfurt, whereas the intake of raw vegetables was lower. The most striking differences appeared in the consumption of fat.

Diet↗
PubMed1992

In vitro phagocytosis by crevicular phagocytes in various forms of periodontitis.

Phagocytes from the gingival crevice fluid (CF-cells) of 11 patients with localized juvenile and post-juvenile periodontitis (LJP/PJP), 14 with rapidly progressive periodontitis (RPP), 11 with adult periodontitis (AP), and 14 controls without periodontal disease were examined. Phagocytic activity in vitro was assessed. Crevicular washings were obtained from healthy sites of controls and diseased sites of patients after completion of the oral hygiene phase (professional and home care). The cells were carefully processed to avoid mechanical damage. The in vitro phagocytosis by uptake of opsonized C. albicans was performed in a moist chamber (30 minutes, 37 degrees C) and examined by light microscopy. CF-cells were differentiated on the basis of their morphological appearance. The majority of cells in crevicular washings were PMNs, some macrophages, and few lymphocytes. Phagocytic activity in patients with LJP/PJP and RPP was significantly decreased in comparison with that from AP and the control group. The decreased percentage of cells phagocytosing opsonized C. albicans was associated with the enhanced adherence of opsonized C. albicans. Moreover cell viability of CF-cells from LJP/PJP sites was significantly reduced. The data from the present study suggest that the in vitro phagocytosis of crevicular phagocytes in juvenile and rapidly progressive periodontitis lesions is diminished.

Adolescent↗
PubMed1990

[Basic program of myocardial infarct after-care].

The further diagnostics and therapy is performed after classification of the patients in groups with different prognosis. The decision, whether or not an invasive diagnostics is necessary and which medicaments are prescribed is based on the results of non-invasive diagnostic measures. The beta-blockers are the most important group of medicaments. Anticoagulants and antiarrhythmic drugs are used within limited and defined indication. A broad application of thrombocyte aggregation inhibitors seems to be justified according to latest studies. The consequent elimination of coronary risk factors has ascertained prognostic effects.

Adrenergic beta-Antagonists↗
PubMed1989

[Dose-reduced antihypertensive agents--use in complex nonmedicamentous therapy of hypertension].

In order to estimate the influence of a non-medicamentous therapy (CNT) on the consumption of medicaments and coronary risk in high blood pressure 73 hypertensives of a medicamentously stabilized CNT-group were examined in comparison to a group of the same size of patients with hypertension who were managed exclusively medicamentously for behaviour of blood pressure, need of antihypertensive drugs and changes of hypertension-associated risk factors. After an exactly controlled 6-month treatment hypertensives with additionally recommended far-reaching CNT showed an economization of medicaments by scarcely the half in comparison to the reference group. By means of suitable control methods a causal non-medicamentously conditioned decrease of blood pressure could be excluded. A different need of antihypertensive drugs was simulated by the exacter intake of medicaments in the index-patients. Notwithstanding the metabolic effects of the additional therapy have induced a positive change of atherogenic lipids. The examinations indicate in general the difficulty of the judgement of efficacy of non-medicamentous therapeutic measures in connection with a rational dose-reduced long-term therapy with antihypertensive drugs.

Adult↗
PubMed1989

[How does the rate of participation in epidemiologic research affect oral health data?].

The question to which extent an unintended selection is linked with incorrect estimations of oral disease indicators by the readiness of subjects to participate is looked into within the framework of an epidemiological study. 896 primarily cooperative subjects and 70 originally noncooperative subjects aged from 25 to 64 years were examined. According to statistics, non-cooperative subjects were found to have more caries-infected teeth and less teeth filled. Generally, a smaller degree of dental care could be detected in these subjects, which should cause a critical discussion of the hitherto published parameters of oral diseases.

Adult↗
PubMed1989

[Is there a connection between coronal and root caries involvement?].

The relationship between coronal and root caries was analyzed in a sample of 963 people aged 25 to 64 years. Subjects with root caries had fewer teeth, more teeth with untreated coronal caries, and more teeth which need conservative treatments and extractions than did people with no root caries. In the age older than 55 years those with root caries had more teeth in the average of 2.5 teeth for both sexes. The other parameters of dental health showed the same differences compared with younger subjects.

Adult↗
PubMed1988

The degradation of platelet-activating factor in serum and its discriminative value in atherosclerotic patients.

Platelet-activating factor (PAF) is transformed in vivo rapidly into the biologically inactive lyso-PAF. This reaction as well as lipid parameters were quantified in serum from 40 survivors of myocardial infarction and 36 healthy controls matched for age and body weight. The PAF-degrading capacity was 23% (p less than 0.001) higher in patients compared with the control group. Using the degradation of PAF as an univariate discriminator more than 70% of subjects were classified correctly. This is comparable with the discriminatory value of the best lipid variables, apolipoprotein B and HDL-cholesterol. Statistically significant differences in the degradation of PAF were found also by comparing subgroups which were matched for plasma levels of total cholesterol, VLDL/LDL-cholesterol or apolipoprotein B. The ratio by 48% (p less than 0.0001) in the case group was identified as an additional good discriminator between both groups. In contrast, platelet aggregation tests which were performed in acetylsalicyclic acid treated platelet-rich plasma discriminated poorly between patients and controls.

Apolipoproteins↗
PubMed1988

[Nifedipine therapy in uncomplicated essential hypertension and hypertensive problem cases].

In altogether 54 patients with high blood pressure of the clinical degrees of severity I-IV the blood pressure-reducing effectiveness of the calcium antagonist nifedipine was investigated both in the framework of an oral long-term therapy and especially in problematic situations of high blood pressure. According to the results of own treatment nifedipine is particularly suited for the antihypertensive combination therapy with beta-receptor blockers. Monotherapeutically favourable possibilities of application exist in hypokinetic types of the regulation of circulation as well as in elderly hypertensives. Therapy-resistant as well as crisis-like developments of high blood pressure react with excessive, well tolerable and persisting reductions of blood pressure. Above all with regard to this still little considered indication in the meantime nifedipine represents an unavoidable enrichment in the therapeutic basis spectre of the hypertonus.

Adult↗
PubMed1988

[Status and perspectives of prevention in coronary heart disease].

The outstanding objective prerequisites for the protection of life and health of the whole population, which are at our disposal, have quite significantly widened the possibilities for individual decisions and actions concerning the influence on health and functional capacity as well as responsibility and cooperation of every citizen. Comprehensively, also in our country the readiness of all citizens must be stimulated to form the personal way of life according to the scientific knowledge fully using the abundantly given possibilities. In this respect we too have to solve still great problems.

Coronary Disease↗
PubMed1988

[Results of a 2-year intervention for the modification of atherosclerosis precursors in school children].

801 children aged 10-11 years were examined in 1984, before an allocation in two groups (intervention vs. control). The scope of the intervention was to modify mean values of blood pressure, total cholesterol and smoking through relevant modification of knowledge and behavior. An intermediate assessment, conducted 2 years after the first exam, showed better knowledge regarding cardiovascular diseases and more sport practice in the intervention group, although smoking habits were only slightly modified. Diet, body weight, blood pressure and blood lipid levels did not show any significative differences. The study is now ongoing.

Anthropometry↗
PubMed1987

Atherosclerosis precursors in schoolchildren--results of a two-year intervention study.

In order to reduce precursors of atherosclerosis, an intervention trial was carried out in pupils aged 10-11 years at the time of inclusion into the study (5th graders). The main goal of the study was to encourage health-promoting behaviour patterns--mostly present in the schoolchildren at that time--such as non-smoking, a negative attitude toward future smoking, a high level of physical activity including sports. The study design included dietary measures aimed at lowering blood pressure and total cholesterol values. Follow-up examination, performed at an interval of 2 years, revealed the following results: significantly lower mean total cholesterol values in girls attending the intervention schools; a significantly lower prevalence of smoking and a decrease in the number of casual smokers--compared with data obtained in the 5th grade--in the intervention schools; a negative attitude towards smoking and the extent of sport activities remained at the level of the 5th grade in the intervention schools.

Arteriosclerosis↗