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Biomedical subjects

H Honegger

Publications and source records attributed to H Honegger.

At least 37 records · Page 2Linked to original sources
PubMed1981

Antithrombin III profiles in malignancy, relationship primary tumors and metastatic sites.

Variations of antithrombin III were studied in a non-randomized population of consecutive cancer cases admitted to a referral hospital. Differences between functional and immunologic assay were observed. Decreases were observed in both assays when compared to a population of hospitalized controls. Patients with cancer of the colon, ovary and prostate showed a deficiency of antithrombin III more frequently than other common tumors. When all tumor cases were subdivided into those in remission compared to those with metastases, a significant decrease in antithrombin III also could be shown. Metastases to the liver were strikingly common in cancer patients with decreased antithrombin III. In these patients, the decrease in antithrombin III could be statistically correlated with reduction in serum albumin.

Antithrombin III↗
PubMed1980

Morphological changes of the corneal epithelium after application of topical anaesthetic ointments.

The effect of topical anaesthetic ointments (4% cocaine, 4% xylocaine, 0.5% proparacaine, 0.2% oxybuprocaine) on the corneal epithelium of rabbits was examined using a scanning electron microscope. Even after a single application, the more toxic effect of cocaine compared to the other topical anaesthetics was evident. Cocaine caused disruption of both the plasma membrane and the cytoplasm. After a single application, the other preparations caused a marked decrease in the microvilli and microplicae, disruption of the intercellular spaces and the prominence of the cell nucleus which under normal condition is not visible. Repeated applications caused regular cell desquamation and damage to the plasma membrane and cytoplasm. The damage also affected several cell layers. The cell reactions described are clearly a consequence of the topical anaesthetics, as the ointment base itself produced no essential cell damage. The scanning electron microscope findings were supported by results from the transmission electron microscope.

Anesthetics, Local↗
PubMed1979

Early morphological changes of the corneal epithelium after burning with hydrochloric acid. A scanning electron microscope study.

The morphological changes of the corneal epithelium after burning with hydrochloric acid were examined using a scanning electron microscope. A drop of hydrochloric acid of differing concentrations (1--0.000001 N HCl) was applied under standardized conditions to normal rabbit eyes for a reaction period of 5 or 30 min. The changes in the cell surface, which are dependent on the concentration of the acid, include a loss of microvilli and microplicae, outlining of the cell nucleus, disruption of the intercellular spaces, cell desquamation and even the most severe damage to the cell membrane and cytoplasm of the corneal epithelial cells.

Animals↗
PubMed1978

[Perimetry during monocular and binocular fixation with the phase-difference haploscope of Aulhorn].

For the first time it was possible to compare perimetry during monocular and binocualr fixation under homogeneous conditions by the aid of phase-difference haploscopy. A binocular perimetry was not practicable using common perimeters. The examination was based on the anatomical fixed papilla nervi optici, which appears in the visual field as the blind spot. Its extension corresponds more to the anatomical size during binocular examination than during monocular examination. The difference is highly significant. Likewise the binocular perimetry refers to the quality of reproduction of paracentral retinal diseases significantly improved compared with the monocular examination. Supposing that the use of a larger fixation target during monocular perimetry contributes to the stabilization of normal eye movements, all examinations were additionally made with two fixation targets of different sizes. We have shown that there is no significant difference between the measurement either concerning the extension of the blind spot or the paracentral retinal diseases, which means a larger fixation target represents no fixation aid.

Fixation, Ocular↗
PubMed1978

[The influence of local anesthetics on corneal epithelium. A scanning electron microscopic study (author's transl)].

The effect of different local anesthetics (Cocain 4%, Lidocaine 2%, Proparacain) on the corneal epithelium in rabbits was examined under scanning electron microscope. The experiment was divided into three groups. Group 1 received one application of two drops of the given local anesthetic for a reaction time of 5 minutes. Group 2 received two drops of the given anesthetic after 0, 5 and 10 minutes. The cornea was excised after 15 minutes. Group 3 were measured after a single application of Proparacain using a Schiötz or hand applanation tonometer according to Draeger. After a single dose of a local anesthetic principally the same changes in the surface of the cornea were observed with all the preparations used: a distinct decrease in the number of microvilli and microplicae, disruption of the intercellular spaces and the prominence of the cell nuclei which under normal conditions are not visible. After several applications the greater toxicity of Cocain compared with the other preparations was clearly seen through the disruption of the plasma membrane and the cytoplasm. The damage effected several layers of cells. Tonometry when correctly performed causes no additional damage to the cell surface.- The effect of local anesthetics on the cell membrane can only take place after the disruption of the tear film. The results emphasize that local anesthetics should only be applied when absolutely essential.

Anesthetics, Local↗
PubMed1975

[Morphology of the corneal endothelium under normal conditions and during regeneration after mechanical injury].

On a preparation of the corneal endothelium membrane from a rabbit, the morphological structure of the endothelium is examined under normal physiological conditions and during regeneration after abrasion by mechanical means. Thematerial which is submitted here is outlined in two chapters: (1) The morphology of the normal corneal endothelium; (a) in the contest of the literature on the subject, (b) in comparison with different methods of preparation. (2) The morphology of endothelium regeneration; (a) in the literature as physiological regeneration and, after experimental abrasion, as a model for human endothelium pathology, (b)as a systematic examination at different points of time after mechanical abrasion and in single phases of indirect and direct cell multiplication. After a survey of the comprehensive literature on the subject, several histological fixations and methodds of endothelium preparation as a membrane are given. In a comparison of the findings of the presentation of the normal endothelium, these methods are described in virw of a specific presentation of pathological endothelium rocesses. On the basis of the dyeing characteristics of the cells after intraocular pre-fixation; the evidence of the viscous mucopolysaccharoid membrane on the cell surface (the membrane having been dissected from the endothelium) is discussed...

Animals↗
PubMed1975

[Tonography test according to Leydhecker. Clinical comparison by tonography according to Grant (author's transl)].

In our 1st series of examinations the Grant's 4-minutes-tonography, combined with waterdrinking (Becker), was compared with Leydhecker's modification of 7-minutes-tonography. Out of 60 healthy eyes were 13,3% false-positive with the 4-minutes-tonography, combined with waterdrinking, however with the 7-minutes-tonography none of these were glaucoma-suspicious. For 92 glaucoma-suspicious eyes, which were tested with both methods, the 7-minutes-tonography proved to be much more valuable. Leydhecker's value P3/CL3-7 offers 38,4% positive results at a starting pressure of 18-22 mm Hg, and 51,1% positive results at a starting pressure of 20-24 mmHg. Grant's 4-minutes-tonography, combined with waterdrinking (Becker), may show suspicious values at pressures of 18-22 mm Hg, however is not able to register with certainty existing pathological findings. In 2nd series of examinations 54 eyes with proven glaucoma chronicum simplex were tested with the 7-minutes-tonography. It showed a reliability of 83%.

Chronic Disease↗