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H Hudziak

Publications and source records attributed to H Hudziak.

10 recordsLinked to original sources
PubMed2000

[Evaluation of a new sequence of magnetic resonance cholangio-pancreatography in thick cut and one shot acquisition].

OBJECTIVES: To assess the accuracy and reproducibility of a new magnetic resonance cholangiopancreatography sequence (MRCP), using long echo time and "single shot" acquisition (providing high-contrast thick slices: 20 mm or more), in the morphological analysis of the biliary tree and pancreatic ducts. METHODS: Fifty four patients with biliary and/or pancreatic disease were investigated with MRCP "single shot" thick slices. Biliary ducts were explored with MRCP "single shot", coronal and oblique coronal 20 mm thick slices on a 256 x 256 matrix. Natives pictures were reviewed by three independent radiologists, from three different institutions. MRCP results were compared with reference examinations in 54 cases (direct biligraphy methods: 54, CT scan: 11, endoscopic ultrasonography: 6, surgery: 6). RESULTS: For detection of bile duct dilatation, the agreement of MRCP "single shot" thick slices was more than 96% (Kappa > 0.92) and the inter-observer agreement was excellent (Kappa=0.92). For detection of biliary tree and/or pancreatic duct obstruction, MRCP "single shot" thick slice sensitivity was above 89% and specificity was 75%. The malignant nature of the lesions was determined with a sensitivity of 100% and a specificity of 92%. MRCP "single shot" thick slices could not differentiate pancreatic carcinomas from distal main bile duct cholangiocarcinomas. MRCP "single shot" thick slices did not detect small stones ( 3 mm) of the common bile duct. CONCLUSION: The excellent sensitivity, specificity and inter-observer agreement of MRCP "single shot" thick slices can be used to limit invasive imaging methods in the diagnosis of extrahepatic cholestasis.

Adult↗
PubMed1997

Lymphocyte reactivity to hepatitis C virus (HCV) antigens shows evidence for exposure to HCV in HCV-seronegative spouses of HCV-infected patients.

Lymphocyte reactivity against hepatitis C virus (HCV) antigens was studied in 20 couples in which 1 member had chronic hepatitis C. This was done to investigate the possibility of HCV transmission between spouses that was not followed by seroconversion. Twenty healthy subjects without any risk factors for HCV transmission served as negative controls. All the patients' spouses and the healthy controls were negative for HCV RNA and for anti-HCV antibody. Lymphocytes were cultured with recombinant HCV core and nonstructural antigens (c22, c33, c100, c200, and NS5) and with control antigens (sperm whale myoglobin, chicken lysozyme, and superoxide dismutase). Lymphocytes from 10 patients and 4 seronegative spouses proliferated in the presence of at least one HCV antigen. No proliferation was shown with nonspecific antigens or in the control group. This study gives evidence for possible in vivo priming with HCV antigens that did not lead to seroconversion in spouses of HCV-positive patients.

Adult↗
PubMed1997

Achalasia: outcome of patients treated with intrasphincteric injection of botulinum toxin.

BACKGROUND: To evaluate the safety and clinical efficacy of botulinum toxin (BT) in patients with achalasia followed up for six months. METHODS: Fifty five symptomatic patients with manometrically proven achalasia were included in a multicentre prospective trial. Before and two weeks and two months after intrasphincteric injection of BT, symptoms of dysphagia, regurgitation, and chest pain were scored on a 0-3 scale, and lower oesophageal sphincter pressure (LOSP) was assessed. The symptom score was determined again at six months, clinical improvement being defined by < or = 3, relapse by > 3, and failure as a relapse after two injections or loss to follow up. RESULTS: Except for transient chest or epigastric pain (22%), no side effects were observed. There was a significant decrease in LOSP after treatment. Symptom scores were significantly improved at two weeks (2.0 (SD 1.6)), two months (1.7 (1.8)), and six months (1.9 (2.0)) compared with pretreatment values (5.1 (1.8), p < 0.001). At six months, 33 patients had clinical improvement (27 after one injection), 17 were considered failures, and five had just relapsed. Although there was a trend for age (older patients being more responsive), age, sex, prior duration of symptoms, initial symptom score, weight loss, LOSP, magnitude of oesophageal contractions, vigorous or non-vigorous achalasia, previous dilatations, and radiological features were not predictive of results. CONCLUSIONS: This multicentre series confirms that intrasphincteric injection of BT is a safe procedure, resulting in clinical improvement in 60% of patients with achalasia at six months. The therapeutic role of BT in achalasia needs further evaluation with regard to other alternatives.

Adult↗
PubMed1996

[Low-dose polyethylene glycol 4000: digestive effects. Randomized double-blind study in healthy subjects].

OBJECTIVES: It was recently demonstrated that low-dose polyethylene glycol 4000 (PEG) electrolyte lavage solution, a colonic lavage solution used for cleaning the gut before colonic procedures, is effective in the treatment of chronic constipation. The aim of our study was to determine the digestive effects of low-dose PEG 4000 without electrolyte addition in healthy subjects. METHODS: Sixteen healthy male subjects with normal transit were included in a randomized controlled cross-over study. Study design included 4 successive periods: pre-inclusion (12 days), treatment (7 days), wash out (7 days), treatment (7 days). Colorectal transit time measurement and stool collection for physical and chemical investigations were performed during each period. During treatment period, either 20 g/d of PEG without electrolyte addition or placebo was given to each subject. RESULTS: With PEG, stool frequency increased significantly (1.26 +/- 0.09 with PEG versus 1.07 +/- 0.09 with placebo; P < 0.05) but no significant change in consistency was observed (P = 0.07). Total and segmental colonic transit time were comparable with PEG and placebo. Mean stool weight increased from 74 g/d, by increase of stool water output (54 g/d) and dry stool weight (20 g/d). Increase of stool water output was not associated with improvement in stool hydration: stool water content was comparable with PEG (75.4%) and with placebo (75.6%). No change was observed for the following parameters: stool electrolytes output, pH, organic acids, fecal output of fat, alpha-1-antitrypsin clearance, presence of red and white blood cells. Fecal output of protein increased significantly from 3.2 +/- 0.4 g/d to 6.0 +/- 0.7 g/d (P < 0.05). CONCLUSION: No effect on colonic transit and on stool hydration was observed with low dose of PEG 4000. With 20 g/d of PEG 4000, electrolytes addition is not necessary.

Adult↗
PubMed1995

Schnitzler's syndrome: two case reports and review of the literature.

Schnitzler's syndrome is a combination of chronic urticaria, fever of unknown origin, disabling bone pain, hyperostosis, increased erythrocyte sedimentation rate, and macroglobulinemia. Since it was first described in 1974, only 26 cases have been published in the literature. In this report, we describe two additional cases and review the clinical features and pathogenesis of this uncommon syndrome.

Aged↗