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Biomedical subjects

H Ichimura

Publications and source records attributed to H Ichimura.

At least 73 records · Page 4Linked to original sources
PubMed1985

Neutralizing antibody and interferon-alpha in cerebrospinal fluids and sera of acute aseptic meningitis.

Cerebrospinal fluids (CSFs) and sera from 20 patients with echovirus 30 (E 30) meningitis, 4 patients with enterovirus 71 (EV 71) meningitis, and 5 patients with acute aseptic meningitis (AM) of unknown etiology were investigated at the acute and the convalescent phases of the disease to elucidate the roles of neutralizing antibody (NT) and interferon-alpha (IFN-alpha) in the central nervous system (CNS) in cases of AM in humans. Viruses were isolated from the CSFs at the acute phase of AM, but not at the convalescent phase. There was a fourfold or greater rise in NT titer between paired sera to E 30 or EV 71 but only a slight rise between paired CSFs. IFN-alpha was detected in the CSFs ranging from less than 10 to 25.5 IU/ml but not in the sera, and the IFN-alpha level in the CSF was significantly higher in the acute phase than in the convalescent phase. These results suggest that in cases of acute enteroviral infections in the CNS, NT plays only a small role in the recovery from AM, and IFN-alpha plays a direct or indirect role in curbing the local spread of the virus and eliminating the virus from the CNS at the acute phase of AM.

Antibodies↗
PubMed1985

Persistence of hepatitis B e antigen for a long period after the clearance of hepatitis B surface antigen.

Four-hundred and seventy-eight hepatitis B virus (HBV) carriers were followed for more than 60 months. In thirty-six cases the hepatitis B surface antigen (HBsAg) was cleared from serum during the observation period. In one case hepatitis B e antigen (HBeAg) was detectable for more than 66 months even after the appearance of antibody against hepatitis B surface antigen (anti-HBs). HBeAg was detected not only by radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA), but also by reversed passive haemagglutination (RPHA) method which has been believed to be far less sensitive than RIA or ELISA tests. HBV DNA was demonstrated in the serum even after the appearance of anti-HBs. Therefore, it is suggested that HBV (Dane particles) remains or reappears intermittently in the serum after seroconversion of HBsAg antigenaemia to anti-HBs complexes.

Carrier State↗
PubMed1984

Comparison of actual survivorship after treatment with survivorship predicted by actual tumor-volume doubling time from tumor diameter at first observation.

The predicted survival time of 56 patients with lung cancer was calculated using Geddes ' nomogram for tumor diameter and tumor doubling time. The predicted survival time correlated favorably with the actual survival time. For many patients with resection the actual survival time far exceeded the predicted survival time; thus, the latter may be very useful as a control for the evaluation of all therapies of lung cancer.

Adenocarcinoma↗
PubMed1982

Pure red cell aplasia following irradiation of an asymptomatic thymoma.

An unusual case of pure red-cell aplasia (PRCA) developed sixteen days after irradiation of an asymptomatic thymoma. After removal of the encapsulated thymoma there was no improvement in the anemia, and no response to adrenocortical and anabolic steroid hormones or immunosuppressive agents.

Anemia, Aplastic↗
PubMed1982

Sex steroid receptors in diverse human tumors.

The estrogen receptor was assayed in 8 intracranial meningiomas, 14 lung cancers, 3 thymomas and 2 malignant lymphomas using the dextran-charcoal method. Progesterone and androgen receptors were also assayed in all the cases of lung cancer. The estrogen receptor assay was positive in 3 meningiomas, 2 lung cancers, and all thymomas and malignant lymphomas. The androgen receptor assay was positive in one case of lung cancer but the progesterone receptor was negative in all assayed cases. No cases showed multiple receptor positivity. An antiestrogen (tamoxifen) was administered to one case each of intracranial meningioma and lung cancer with positive estrogen receptor. The receptor content was decreased to an undetectable level in the former after 4 months of administration. This finding suggests the estrogen dependency of the tumor. The lung cancer patient, however, died 2 weeks later without any evidence of hormone dependency.

Adenocarcinoma↗