Biomedical subjects

H Illner

Publications and source records attributed to H Illner.

28 records · Page 2Linked to original sources

PubMed1982

Effects of naloxone in hemorrhagic shock.

The endorphins appear to play an integral role in the physiopathology of hemorrhagic shock. Blockade of these endodgenous opiates by naloxone can significantly alter the course of this syndrome. While the administration of naloxone to normal rats had no effect upon the circulation or cellular function, it improved the hemodynamic status of rats subjected to hemorrhagic shock, resulting in improved tissue perfusion. In addition, the administration of this drug prevented the cellular dysfunction normally seen in hemorrhagic shock. This effect was independent of its salutary effects upon the circulation.

Animals↗

PubMed1980

The effect of hemorrhagic shock on potassium transport in skeletal muscle.

The ion exchanger potassium microelectrode was used to assess the potassium concentration in the interstitial fluid of skeletal muscle in the control and shock states. Concomitant resting membrane potential measurements and the analysis of fluid and electrolyte content of biopsies of the muscle were used to detect defects in cellular function. The changes occurring in hemorrhagic shock were consistent with a depression of resting transmembrane potential, depletion of extracellular fluid and cellular swelling with sodium uptake and potassium loss. The disproportional increase of interstitial potassium concentration over that of the plasma in low flow states appeared to be a result of inhibited sodium-potassium transport in cell membranes, concomitant with an equilibration delay between these two extracellular compartments. The significant increase in potassium concentration in the interstitium may have potentiated other changes in cardiovascular and respiratory functions which have been observed in the complex picture of hemorrhagic shock.

Animals↗

PubMed1979

The effect of septic shock on skeletal muscle action potentials in the primate.

Techniques developed for the in vivo study of cellular physiology have been applied to septic shock in primates. Measurements of skeletal muscle transmembrane resting and action potentials were correlated with an analysis of fluid and electrolyte changes in the intracellular and extracellular compartments of skeletal muscle. The data obtained indicated a marked depletion of muscle extracellular water and an increase in intracellular sodium chloride and water content during shock. The significant decrease of resting membrane potential was associated with a decrease in amplitude of the action potential and prolongation of both the repolarization and depolarization time. In addition, there was a decrease of muscle intracellular potassium concentration during shock. This study demonstrates that the alterations in cellular membranes in hemorrhagic shock and septic shock are similar.

Action Potentials↗

PubMed1976