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Biomedical subjects

H Isager

Publications and source records attributed to H Isager.

At least 37 records · Page 2Linked to original sources
PubMed1982

Tear absorption into the filter-paper strip used in the Schirmer-I-test. A methodological study and a critical survey.

The absorption of tear fluid into the Schirmer-I-filter paper was evaluated by serial measurements in 5 normal volunteers and in 32 patients with Sjögren's syndrome. The length of wetting was correlated to the weight of tear fluid absorbed in the paper strips. A linear relationship was demonstrated. We conclude that the Schirmer-I-test implies reproducible and fairly precise estimation of the tear flow even in cases of small lengths of wetting. The test is reliable, simple and useful for the diagnosis and follow-up of dry eyes, especially in patients with Sjögrens syndrome.

Absorption↗
PubMed1982

Cobalamin-binding proteins in serum and saliva from patients with Sjögren's syndrome.

Cobalamin-binding proteins in saliva and in serum were determined in 28 patients with primary Sjögren's syndrome (primary SS), 8 patients with secondary SS and 20 matched healthy controls. The unsaturated transcobalamin II level in serum was significantly increased in patients with secondary SS. The unsaturated cobalamin binding capacity in saliva was increased in patients with primary SS. Considerable interindividual variations were found between patients and in the control group. The local production of cobalamin-binding proteins in SS was sufficient to achieve concentrations in saliva comparable to the control group. The cobalamin-binding capacity in saliva was significantly correlated to the albumin concentration in both primary and secondary SS patients, suggesting a defect in the aqueous phase.

Adult↗
PubMed1981

Bromhexine treatment of Sjögren's syndrome: effect on lacrimal and salivary secretion, and on proteins in tear fluid and saliva.

In a randomized clinical study, 32 patients with Sögren's syndrome (SS were given placebo/bromhexine (Bisolvon) 48 mg daily for 3 weeks. Various ophthalmological and oral variables as well as different proteins in the tear fluid and saliva were registered. Bromhexine stimulated the tear secretion significantly, presumable without changing the protein composition of the tear fluid. In contrast to other proteins in saliva the IgM concentration decreased in patients with high pre-treatment values. Bromhexine may be of valuable help in the treatment of some patients with SS.

Adult↗
PubMed1978

Sjörgren's syndrome treated with bromhexine: a randomised clinical study.

Existing treatment for Sjögren's syndrome is unsatisfactory, and uncontrolled observations have suggested that bromhexine may be effective. Twenty-nine patients with Sjögren's syndrome were therefore assigned to two randomised double-blind crossover trials with bromhexine and placebo, each comprising two two-week periods. In the first trial bromhexine 24 mg/day was given by mouth; in the second the dose was increased to 48 mg/day. After each treatment period the Schirmer test response, break-up time, Bijsterveld score, and the time taken for the patient to eat a dry biscuit were recorded, as well as the patient's estimate of moistness in the eyes and mouth. In the second (higher-dose) trial values on the Schirmer test were significantly higher after bromhexine than after placebo and the break-up time was also increased after bromhexine, which suggested that the drug has a dose-dependent effect on lacrimal gland secretion in Sjögren's syndrome. It had no effect on salivary gland function. Bromhexine is therefore valuable in the treatment of Sjögren's syndrome.

Bromhexine↗
PubMed1978

Pre-morbid factors in Hodgkin's disease. I. Birth weight and growth pattern from 8 to 14 years of age.

The risk of Hodgkin's disease (HD) in young adults is correlated to height. This association indicates an etiologic factor acting during growth. Our aim was to evaluate the importance of growth pattern as a risk factor in HD. The register of records from the school health service of the Copenhagen Council was scrutinized in order to find Danes with HD born between 1930 and 1950. Whenever possible, three matched controls (comparable in respect to socio-economic status) were selected from the register for each case. The material consisted of 63 cases and 183 controls. Information regarding height, weight and birth weight was obtained from the school health records. The patients were taller than controls at 8, 10, 12 and 14 years of age. The birth weight was available in 33 cases and 99 controls, and was higher in the former (median 3.50 kg) than in the latter (median 3.30 kg) (P less than 0.01). Our findings suggest the existence of either a risk factor associated with rapid growth or a protective factor connected with slow growth, effective even before birth.

Adolescent↗
PubMed1978

Pre-morbid factors in Hodgkin's disease. II. BCG-vaccination status, tuberculosis, infectious diseases, tonsillectomy, and appendectomy.

In young adults with Hodgkin's disease, cell mediated immunity (CMI) was evaluated retrospectively from their health records. The register of records from the school health service of the Copenhagen Council was scrutinized in order to find the records of those with HD born between 1930 and 1950 in whom the disease had been diagnosed between 1943 and 1975. Whenever possible, three controls were selected from the register for each case; they were comparable in respect of sex, year and month of birth and socio-economic background. The material consisted of 63 cases and 182 controls. Information regarding BCG-vaccinations, tuberculin skin-tests, the frequency of tuberculosis, bacterial and viral diseases, and of tonsilectomy, adenoidectomy and appendectomy was obtained from the school health records. 2 HD patients have had tuberculosis versus none in the control group. Complications to or prolonged course of viral diseases were reported neither in HD patients nor in controls. No significant differences were found in the frequency of BCG-vaccination, tuberculin reactivity, viral and bacterial diseases, adenoidectomy, tonsilectomy and appendectomy. Therefore our findings do not support the concept of a pre-morbid CMI deficiency state in HD.

Adenoidectomy↗