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Biomedical subjects

H Isago

Publications and source records attributed to H Isago.

14 recordsLinked to original sources
PubMed1986

A case of Weber-Christian disease accompanied by a nasal symptom (a clinicopathologic case report).

A rare case of fatal Weber-Christian disease is reported. The initial presenting signs were unilateral nasal obstruction due to hyperplasia of the ulcerated turbinate, swollen cheeks and eyelids accompanied by recurrent febrile episodes. The nasal lesion showed marked inflammatory granulation tissue with necrosis and there were 'atypical' reticulohistiocytic cells. Subsequently the patient developed widespread nodular nonsuppurative panniculitis of the left thigh. The patient's general condition worsened in spite of cytotoxic and steroid treatment and he died of acute peritonitis from a perforated duodenal ulcer complicating the treatment. Microscopy showed that some atypical cells were present not only in the nasal lesion but also in the lesions of the skin and in the sinusoids of the liver and in the spleen. Weber-Christian disease secondary to midline granuloma or malignant histiocytosis has not previously been reported.

Humans↗
PubMed1986

Vestibular-visual conflict in pitch and yaw planes in the squirrel monkey.

Direction conflicting vestibular and visual (optokinetic) stimuli either in the pitch or yaw plane were given to squirrel monkey subjects. The conflict sickness symptom score in the pitch plane was significantly higher than that in the yaw plane for the initial exposure session (p less than 0.01). A significant score difference was also encountered when the exposure sessions were repeated (p less than 0.05).

Animals↗
PubMed1985

A case of periodic alternating nystagmus: with a special reference to the efficacy of baclofen treatment.

A case of periodic alternating nystagmus (PAN), probably of congenital type, was reported. A 25-year-old woman, who has been suffering from cerebral palsy, was referred to our clinic for the consultation of a peculiar nystagmus and intermittent oscillopsia. Electronystagmographic examination revealed that the horizontal nystagmus on straight ahead gaze in the light continuously changed its direction alternately about 110 sec in right direction and about 90 sec in left direction with about 5 sec of an interlude, during which no nystagmus was observed, between each span. Electronystagmographic recording also illustrated that the amplitude and slow phase eye velocity of PAN first increase and then decrease in each span. Since other various kind of examination including neuroradiological examination revealed no special abnormality except for the signs of cerebral palsy, congenital PAN was suspected in this case. Although previous report indicated that baclofen dose not control congenital PAN in contrast to that of acquired type, we tried baclofen in this case. Baclofen reduced the strength of the nystagmus remarkably and patient also recognized the considerable improvement of her oscillopsia. We are of the opinion that the baclofen may improve the strength of congenital PAN and oscillopsia as well as those of acquired type PAN.

Adult↗
PubMed1983

The effect of amphetamine on head and eye movements following vestibular stimulation in squirrel monkeys.

The effect of a single dose intra-muscular injection of amphetamine sulfate on head and eye movements evoked by vestibular stimulation was investigated in squirrel monkeys. Doses injected were 0.5, 0.4, 0.3, 0.2 mg/kg, and control no injections. Amphetamine did not change the gain of vestibular evoked head and eye movements, but prolonged time constant (in function of dose) showing greater effect in eye movements. More than 0.3 mg/kg was found to be a proper dose for this species to maintain an appropriate constant alertness level for vestibular studies.

Amphetamine↗
PubMed1983

Effect of amphetamine on optokinetically evoked head and eye movements in the squirrel monkey.

The effect of amphetamine sulfate injection on head and eye movements evoked by optokinetic stimulus was studied in squirrel monkeys. No change was found in the gain of optokinetic-oculomotor and optokinetic-caputomotor functions, even after the maximum dose (0.5 mg/kg) of amphetamine. Also, no change in eye-head coordination was found. However, amphetamine facilitated the frequency of head nystagmus, whereas that of eye nystagmus did not change. When the poststimulus responses were studied in the dark, both nystagmoid head movement and optokinetic after eye nystagmus showed first phase and second phase. A different effect was found in the duration of these two phases suggesting the existence of distinct generators. Moreover, the synchronized onsets of head and eye nystagmus in both phases, and synchronized occurrence of quick phases indicated the existence of shared neural circuitry between head and eye movements.

Amphetamine↗
PubMed1983

Tympanosclerosis and concentric lamellated bodies in middle ear.

In a case of bilateral tympanosclerosis, in addition to the tympanosclerotic changes, the round (or ovoid) concentric lamellated bodies in the right tympanic cavity (epitympanum and mesotympanum) and mastoid cavity were found. The pathogenesis of tympanosclerosis was discussed in conjunction with those concentric lamellated bodies including its relationship with Pacinian body or middle ear corpuscle.

Aged↗
PubMed1982

Nasal T-cell lymphoma as a type of so-called "lethal midline granuloma".

Six cases were described in which an initial clinical diagnosis of "rhinitis gangrenosa progressiva" or lethal midline granuloma was made. The histological examinations of their surgical and autopsy specimens proved that their nasologic diseases could all be identified as malignant lymphoma arising from the nasal cavity, showing the general histologic characteristics reported for T-cell lymphomata derived from peripheral T-cells. This histologic observation was then confirmed by immunofluorescence studies using various antisera directed toward either human T- or B-cell-surface antigens. These studies clearly demonstrated that their malignant cells bore human Ly-l-like antigen but lacked human TL-like and Ia-like antigens as well as surface-bound immunoglobulins, indicating their peripheral T-cell origin. These data may suggest that so-called "rhinitis gangrenosa progressiva" or lethal midline granuloma contains at least two distinct disease categories, one of which is Wegener's granulomatosis, and the other of which is nasal T-cell lymphoma as described herein.

Antigens, Neoplasm↗
PubMed1982

Upbeating nystagmus resulting from anticonvulsant intoxication. Report of a case.

A rare case of upbeating nystagmus, which occurred under the condition of a loss of visual fixation, due to anticonvulsant intoxication is reported. This patient, a 29 year old male, suffered from grand mal epilepsy for about 12 years, and he had been treated with anticonvulsive drugs. Although a neurological evaluation by a neurosurgeon could suggest the presence of a vague cerebellar sign, neuro-otological evaluation disclosed diverse abnormal findings which clearly demonstrated the presence of dysfunction in the cerebellar system, especially of the verminal and flocculonodular lobe lesion. This may indicate that the anticonvulsive drug affected the vermis and flocculonodular lobe much more than the hemisphere of cerebellum, or that the cerebellar system sign in verminal and flocculonodular lobe lesion and its connection is detected more easily than the hemispheric lesion with the aid of a neuro-otological examination. It was presumed that the upbeating nystagmus in this case was elicited from the lesion of the anterior vermis of the cerebellum and/or its connections. Usefulness and sensitivity of the neuro-otological examination in the field of dysequilibrium of central disorder as well as peripheral vestibular disorder is emphasized.

Adult↗
PubMed1980

Subpopulation of adenoidal lymphocytes of recurrent infection in the upper respiratory tract.

A subpopulation of adenoidal lymphocytes was determined by the E- and EAC-rosetting techniques in order to study an immunological profile of adenoids in 61 children with recurrent otitis media, rhinosinusitis or recurrent tonsillitis. Though there was no significant difference in E- and EAC-rosette forming cells of adenoid tissues from children with recurrent infection in the upper respiratory tract, our results indicated the following. (1) A higher proportion of EAC-rosette forming cells (EAC-RFC) without a change of E-RFC was found in the adenoids of children with recurrent tonsillitis than those without it. (2) The percentage of EAC-RFC appears to increase proportionally to the size of adenoid viewed on the X-ray film. (3) The higher percentage was more remarkable in cases with rhinosinusitis and recurrent otitis media. From the data obtained it is concluded that adenoids may play some part in immunity responses against infection in the upper respiratory tract reflecting adenoidal hypertrophy.

Adenoids↗
PubMedDate not supplied

Comparative morphometry of mammalian otolith organs.

The endolymphatic volume of the utricle and the saccule and the surface area of the saccular macula were measured in eight mammalian species, including humans. The results confirmed that all measurements increased slowly but consistently correlating with increases in body weight. However, differences in these endolymphatic volumes or macular surface areas might also be influenced by functional characteristics among different species rather than simply reflecting geometrical comparability.

Animals↗
PubMedDate not supplied

Utricular and saccular volumetry in human temporal bones.

Using serially sectioned human temporal bones, endolymphatic volumes of utriculus and sacculus were measured with the aid of a computer. The mean of the utricular volume was 8.187 mm3, and the saccular volume, 2.096 mm3. The former was 3.9 X the latter. The surface area of the macula utriculi was 3.271 mm2, and the macula sacculi was 2.188 mm2. The former was 1.5 X the latter. The study using pathologic temporal bones (Meniere's disease, otosclerosis, and otitis media chronica) showed that the utricular volume could indeed increase, and the saccular membrane was found to be more fragile than the utricular membrane in those diseased conditions.

Child, Preschool↗
PubMedDate not supplied

Vestibular-visual conflict sickness in the squirrel monkey.

When combined vestibular and visual (optokinetic) stimuli were given to squirrel monkeys in a direction and phase mismatching sinusoidal mode (in yaw plane), five of six monkeys exhibited actual emesis during three repeated exposures on separate trial days. Two animals vomited on two trial days and three animals, on one day. The incidence took place in 38.9% of the total trial days. When the identical vestibular and visual stimuli were given individually, the effect was negligible, thus confirming each stimulus magnitude was not stressful enough to produce emesis when used separately.

Animals↗
PubMedDate not supplied

Effects of prolonged optokinetic stimulation on oculomotor and locomotor balance functions.

Squirrel monkeys were exposed to optokinetic stimulus (90 degrees/sec constant speed, unidirectional) for 60 min. Eye movements during and after the stimulus exposure were recorded. Comparison of the data between very early and late stages of exposure showed the oculomotor gain increase and the nystagmic frequency decline. Slow phase eye velocity of bilaterally labyrinthectomized squirrel monkeys in the late exposure stage could reach almost to the level of normal animals. Post-stimulus analysis in normal monkeys showed that amphetamine enhanced the optokinetic after-nystagmus duration, the maximum slow phase eye velocity, and the time constant. In contrast, the effect of amphetamine on reversed optokinetic after-nystagmus was not at the significant level in all parameters studied. The manifestation of directional reciprocity of optokinetic after-nystagmus was inconsistent. In bilaterally labyrinthectomized animals, ipsilateral optokinetic after-nystagmus did not appear after the stimulus cessation. Instead, immediate reversed optokinetic after-nystagmus appeared. When the normal animal was kept in the light after the stimulus cessation, slow phase eye velocity of reversed optokinetic after-nystagmus declined relatively rapidly. Reversed optokinetic after-nystagmus and vestibular evoked nystagmus were summated or deducted, in velocity domain, depending upon the direction. Optokinetically induced system imbalance did not depict when the monkey's spinal locomotor function was measured by the platform runway test with the availability of vision.

Animals↗