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Biomedical subjects

H Isomäki

Publications and source records attributed to H Isomäki.

At least 127 records · Page 7Linked to original sources
PubMed1977

Osmic acid in rheumatoid synovitis. A controlled study.

In 24 adult RA patients with knee joint synovitis and bilateral hydrops, the worse joint clinically was treated with osmic acid and 50 mg of hydrocortisone acetate, while the better joint clinically was treated with 40 mg of methylprednisolone acetate (Depot Medrol). After 6 months, hydrops was palpable in 8 joints treated with osmic acid and in 15 joints treated with corticosteroid only. Pain relief was more marked in joints treated with osmic acid.

Adult↗
PubMed1977

Effect of gold treatment on the progression of erosions in RA patients.

The progressive of erosive X-ray changes over a period of 5-6 years was evaluated in RA patients with a low or high dose of gold during the follow-up period. The "low gold" group included 18 patients whose treatment was discontinued because of side effects at a mean dose of 254 mg of Myocrisin. The "high gold" group included 32 patients who received a mean dose of 1858 mg of Myocrisin. Both the number of eroded joints in the hands and feet and the X-ray stage had deteriorated more in the "low gold" group. The inter-group difference was statistically significant. Thus, gold treatment has a retarding effect on the progression of erosions in RA patients.

Adolescent↗
PubMed1977

Osmic acid in rheumatoid synovitis. A controlled study.

Ninety-nine adult RA patients with knee joint synovitis were randomized into two groups. The knee joints of the first group (52 patients) were treated with osmic acid and those of the second group (47 patients) with a placebo. After 6 months, the incidence of hydrops and pain was statistically less significant in joints treated with osmic acid. the result was better in joints without advanced radiological destruction. It is concluded that osmic acid is still of benefit in the local treatment of rheumatoid knee joint synovitis at an early stage.

Adult↗
PubMed1977

Effect of gold on progression of erosions in rheumatoid arthritis. Better results with early treatment.

The advance of radiological destruction in 57 patients with definite rheumatoid arthritis was observed for 5-6 years. In all patients gold treatment was started 2-36 months after the onset of the disease. In 18 patients gold was discontinued because of side-effects of other reasons before reaching the total dosage of 500 mg, while the remaining 39 patients received a mean dose of 2030 mg of natriumaurothiomalate. The advance of the radiological destruction was statistically significantly less marked in patients treated with the full gold therapy. The earlier the treatment was initiated, the better was the result.

Adolescent↗
PubMed1977

Some characteristics of RA patients with and without side effects due to gold treatment.

Gold treatment was initiated in 98 patients suffering from early-stage rheumatoid arthritis. In 30 patients side effects due to gold therapy were seen during the first follow-up year: proteinuria in 6, allergic symptoms in 23, and thrombocytopaenia in one patient. The serum IgM level was higher in patients with side effects. None of the 33 other parameters studied showed any significant differences between patients with or without side effects.

Adult↗
PubMed1977

Gout, particularly diuretics-induced, is one the increase in Finland.

Gout has been considered a rare disease in Finland. However, our hospital series of 77 patients from 1952 to 1976 shows a striking increase during the last 8 years. Over those 8 years the number of persons in the whole country receiving prescribed reimbursable medicines for gout and/or hyperuricaemia rose 10-fold, from 218 to 2188. Diuretics were implicated in one-fourth of our patients-all recent cases. Associated morbidity was high in both obese and non-obese patients. The clinical features and dietary habits of the patients are discussed.

Adult↗
PubMed1977

Morphological findings in joint cartilage after osmic acid treatment.

Punch biopsy specimens from the cartilage of the lateral condyle of the femur in 29 patients suffering from rheumatoid arthritis were taken during surgical synovectomy of knee joints and investigated by light or electron microscopy. Eleven patients had never received osmic acid injections in this particular joint, whereas 18 had had such injections 1-24 months prior to surgery. By light microscopy only minor differences could be seen between controls and cartilage treated with osmic acid, whereas with electron microscopy, increased amounts of dark-staining cell debris were visible in samples taken after osmic acid treatment. The perilacunar matrix appeared normal. There was no irregularity of collagen fibres at the surface of the cartilage. It is concluded that osmic acid causes limited superficial damage to the cartilage. The question whether this is of any clinical consequence in the form of subsequent degenerative joint disease, must be solved by clinical follow-up studies.

Arthritis, Rheumatoid↗
PubMed1977

Death rate and causes of death in RA patients during a period of five years.

Patients with rheumatoid arthritis, 500 males and 500 females, aged 40 years or over, together with an age and sex matched control population, were observed over a 5-year period. During the follow-up 176 RA patients and 107 controls died. The most common causes of death in RA patients were cardiovascular diseases (86 patients), renal failure (33 patients), infections (23 patients), and malignant neoplasms (21 patients); in the controls, the corresponding data are cardiovascular diseases (53), malignant neoplasms (30), infections (9), and accidents (8).

Adult↗
PubMed1976

Causes of death in autopsied RA patients.

Among 3115 autopsied patients, rheumatoid arthritis was registered in 41 patients (1.3%). The causes of death of these were correlated with the causes of death of 310 non-rheumatoid autopsied patients. Of the RA patients, 32% died from cardiovascular disease, 24% from infection, 27% from renal failure and 7% from malignant disease. Of the control patients, 42% died from cardiovascular disease, 9% from infection, 3% from renal failure, and 23% from malignant disease. The low frequency of malignant disease as a cause of death in RA patients may be due to a continuous immunological stimulation or due to a missed diagnosis of RA in patients who died from malignant disease.

Adolescent↗
PubMed1975

HL-A27 and arthritis.

In patients with recent inflammatory arthritis HL-A27 was seen in 6 out of 7 patients with ankylosing spondylitis, in 15 out of 18 patients with Reiter's disease, in 9 out of 12 patients with reactive postinfectious arthritis, in 22 out of 45 patients with rheumatoid arthritis, and in 2 out of 14 patients with other types of inflammatory arthritis. In two control series HL-A27 occurred in 46 out of 326 persons and in 3 out of 34 persons. The high frequency of HL-A27 in RA patients is in disagreement with previous results by other investigators. The explanation for this may be either that the diagnostic criteria do not apply at the early stage of the disease, or that there is a high prevalence of HL-A27 associated RA in Finland.

Adolescent↗