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Biomedical subjects

H Isono

Publications and source records attributed to H Isono.

At least 73 records · Page 4Linked to original sources
PubMed1991

[A case of the persistent sciatic artery].

During the dissecting practice of students at Gifu University School of Medicine in 1989, a rare developmental anomaly showing the sciatic artery was found in the left lower limb of a cadaver of 88-year-old Japanese female. The left sciatic artery (5 mm in diameter) arose from the internal iliac artery and appeared at the buttock between the piriformis and superior gemellus muscles through foramen infrapiriforme. The femoral artery (6 mm in diameter) of the left lower limb was normal in distribution and belonged to the type III by Adachi's classification (1928). The terminal vessel of the femoral artery was joined to the sciatic artery at the popliteal fossa.

Aged↗
PubMed1990

[A case of congenital bicuspid pulmonary valve].

The present report describes a case of congenital bicuspid pulmonary valve which was observed in a male Japanese cadaver of 95 years old during dissecting practice at Gifu University in 1990. No evidence of heart failures was found. The semilunar valve on the left side was bigger than that of the right.

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PubMed1990

Electron microscopic study of the parathyroid gland of the calcium-treated hamster subjected to hypergravity environment.

The ultrastructure of the parathyroid glands of calcium-treated golden hamsters subjected to 5 gravity environment was studied. In the calcium-treated animals exposed to hypergravity environment, the Golgi complexes and cisternae of the granular endoplasmic reticulum were significantly decreased compared with those of the animals exposed to hypergravity environment only and appeared to increase compared with those of the calcium-treated animals, but were almost similar to those of the control animals. In addition, many chief cells contained some prosecretory granules in the Golgi areas, some secretory granules situated close to the plasma membrane and many lysosomes. The morphology of the parathyroid glands in the calcium-treated animals exposed to hypergravity environment resembled that of the control animals. These results suggest that the parathyroid glands suppressed by treatment of calcium and stimulated in response to hypergravity environment may indicate the secretory activity of the parathyroid glands of the control animals.

Animals↗
PubMed1990

Effects of pinealectomy on the ultrastructure of the golden hamster parathyroid gland.

Ultrastructural changes of the parathyroid glands of pinealectomized golden hamsters were investigated. The main changes in the parathyroid glands 1 hour and 1 day after pinealectomy compared with the control and sham-operated groups were an increase of the Golgi complexes, cisternae of the granular endoplasmic reticulum and large vacuolar bodies. In addition, many chief cells contained numerous prosecretory granules in the Golgi areas and many secretory granules in the peripheral cytoplasm. The morphology of the parathyroid glands 7 and 30 days after pinealectomy resembled that of the control parathyroid glands. These results suggest that pinealectomy affects the secretory activity of the parathyroid gland.

Animals↗
PubMed1989

Directionally selective response of cells in the middle temporal area (MT) of the macaque monkey to the movement of equiluminous opponent color stimuli.

Based on the fact that a great majority of cells in the middle temporal (MT) area of the macaque respond to movement of luminance contours with directional selectivity, this area has been thought to be concerned with the analysis of visual motion. However, objects can be discriminated from the background not only by differences in luminance but also by differences in color. It is possible that color signals are also used for motion analysis in MT. In the present study, we examined whether MT cells respond to movement of a pattern composed of pure color-contours. Using a color TV system, a moving color bar was displayed on a uniform background whose color was opponent with that of the bar. The main bar/background color combination we examined was magenta/cyan. Yellow/blue and cyan/magenta combinations were also examined for some cells. The response of MT cells to movements of opponent-color stimuli was recorded while the bar/background luminance ratio was changed from 1/10 to 10/1. In half of 89 cells tested in 3 monkeys, the response decreased considerably (disappeared completely in some cells) at a luminance ratio close to the human equiluminous condition. In the other half, a directional response persisted at any bar/background luminance ratio, though the response decreased to a varied extent (30-90% of the maximum response) near the ratio 1 (human equiluminous condition). The average magnitude of the equiluminous response to the magenta/cyan stimulus for the overall population was about 35% of the maximal response when the length of the bar (0.5 degrees in width) and the movement amplitude were set to be optimal for individual cells, i.e. smaller than 15 degrees and 10 degrees of visual angle, respectively. This fall to 23% when the bar length and movement amplitude were limited to 2 degrees. The same cell responded to pure color-contours of yellow/blue as well as of cyan/magenta combinations. Thus, MT can detect the direction of movement of pure color-contours, although the sensitivity is less than for luminance contours.

Animals↗
PubMed1989

Effects of hypergravity environment on the parathyroid gland of the isoproterenol-treated hamster.

The ultrastructure of the parathyroid glands of hamsters subjected to 5 g environment after an intraperitoneal injection of isoproterenol was studied. In the isoproterenol-treated hamsters exposed to hypergravity environment, the Golgi complexes, cisternae of the granular endoplasmic reticulum and lipid droplets were significantly increased and secretory granules were significantly decreased compared with those of the control group. In addition, many chief cells contained numerous prosecretory granules in the Golgi areas and several secretory granules were situated close to the plasma membrane of the chief cells. These results suggest that the synthesis and release of parathyroid hormone may be markedly stimulated in the parathyroid glands of the isoproterenol-treated hamsters exposed to hypergravity environment.

Animals↗
PubMed1989

Ultrastructure of the parathyroid gland of the mouse fetus after calcium chloride or ethylenediaminetetraacetic acid administration.

Ultrastructural changes of the parathyroid glands of 18-day-old mouse fetuses after administration of calcium chloride (calcium) or ethylenediaminetetraacetic acid (EDTA) were examined. Many chief cells in the parathyroid glans of the calcium-treated mouse fetuses contained poorly developed Golgi complexes and cisternae of the granular endoplasmic reticulum and many secretory granules as compared with those of the control fetuses. Many chief cells in the glands of the EDTA-treated mouse fetuses contained well-developed Golgi complexes and cisternae of the granular endoplasmic reticulum and many prosecretory granules as compared with those of the control fetuses. These findings suggest that calcium or EDTA affects the secretory activity of the parathyroid gland of the mouse fetus.

Animals↗
PubMed1989

Effects of hypergravity environment on the parathyroid gland of the propranolol-treated golden hamster.

The fine structure of the parathyroid glands of propranolol-treated hamsters subjected to 5 x gravity environment was studied. In the parathyroid glands of the propranolol-treated hamsters exposed to hypergravity environment, the volume density occupied by the Golgi complexes and cisternae of the granular endoplasmic reticulum was increased as compared to that of propranolol-treated hamsters and was decreased as compared to that of hamsters exposed to a hypergravity environment but was almost similar to that of control hamsters. In addition, many chief cells contained rich free ribosomes, abundant mitochondria and some secretory granules located in the peripheral cytoplasm. These findings suggest that the parathyroid gland which may be suppressed by treatment of propranolol and stimulated in response to a hypergravity environment indicates the secretory activity of the control parathyroid gland.

Animals↗
PubMed1989

Effects of isoproterenol treatment on the parathyroid glands in golden hamsters of different ages, with special reference to the frequency of lipid droplets.

The frequency of lipid droplets in the parathyroid glands of young, adult and senile golden hamsters after treatment with isoproterenol was investigated. In the parathyroid glands of the young and senile animals the number of lipid droplets increased gradually by 1 h, and thereafter it remained almost unchanged at 3 h after administration. In the glands of adult animals it increased, at first rapidly and then gradually, by 3 h after administration. It is considered that in the parathyroid glands of the golden hamsters stimulated by isoproterenol there is a relationship between the number of lipid droplets and aging.

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PubMed1989

Induction of glutathione S-transferase by phenobarbital in rat hepatocyte culture.

The in vitro effect of phenobarbital on glutathione S-transferase (GST) activity toward 1-chloro-2,4-dinitrobenzene (CDNB) in rat hepatocyte culture was investigated. Treatment of hepatocytes with a medium containing 6 or 8 mM phenobarbital for 20 h increased the specific activity of GST approx. 140% and 160% of control, respectively. When induction of GST by phenobarbital treatment was observed, the cellular level of phenobarbital determined by HPLC was approx. 10 - 15 micrograms/mg of 20000 x g supernatant protein of hepatocytes. Thus, an inductive effect of phenobarbital on GST was observed in vitro as well as in rat liver. It was suggested that a certain level of cellular phenobarbital was necessary for the induction.

Animals↗
PubMed1989

[The anatomical study on the branches of the femoral artery (II). Comparison with the findings of Adachi's classification].

The authors studied the mode of three main branches of the femoral artery (deep femoral, medial circumflex femoral and lateral circumflex femoral artery) in 179 Japanese cadavers during dissecting practice at Gifu University in the last four years. The findings were as follows; Two hundred and seventeen sides in the 352 sides (61.7%) belong to Type I of Adachi's classification on variations in the arrangement of the branches of the femoral artery. Forty-one sides (11.6%) belong to Type II, 55 sides (15.6%) to Type III, 7 sides (2.0%) to Type IV, 8 sides (2.3%) to Type V, 4 sides (1.1%) to Type VI, 5 sides (1.4%) to Type VII and 15 dises (4.3%) to other types. Five cases in 15 sides which belong to other types have been reported in our previous study (Emura et al. 1985). In 3 cases out of 10 sides the deep femoral-medial circumflex femoral trunk, and the ascending and descending branches of the lateral circumflex femoral artery arise from the femoral artery, respectively. In one case out of 10 sides the deep femoral-lateral circumflex femoral trunk and the medial circumflex femoral-inferior epigastric-obturator trunk arise from the femoral artery, respectively. In one case out of 10 sides the lateral circumflex femoral artery and the deep femoral-medial circumflex femoral-inferior epigastric-obturator trunk arise from the femoral artery, respectively. In one case out of 10 sides the medial circumflex femoral-deep circumflex iliac trunk arises from the lateral side of the femoral artery and runs medially behind the femoral artery, and the deep femoral-lateral circumflex femoral trunk arises from the femoral artery. In one case out of 10 sides the deep femoral-ascending (the lateral circumflex femoral artery) trunk, the medial circumflex femoral artery and the deep circumflex iliac-descending (the lateral circumflex femoral artery) trunk arise from the femoral artery, respectively. In one case out of 10 sides the deep femoral-descending (the lateral circumflex femoral artery) trunk, the medial circumflex femoral artery and the ascending branch of the lateral circumflex femoral artery) trunk, the medial circumflex femoral artery and the ascending branch of the lateral circumflex femoral artery arise from the femoral artery, respectively.(ABSTRACT TRUNCATED AT 400 WORDS)

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PubMed1988

Effects of hypergravity environment of the ultrastructure of the golden hamster parathyroid gland.

The fine structure of the parathyroid glands of golden hamsters exposed to 2, 5 or 10 g environment for 5 h was studied. In the centrifuged hamsters, many secretory granules are located in a peripheral position just beneath the plasma membrane of chief cells, and the Golgi complexes and cisternae of the granular endoplasmic reticulum are significantly increased compared with those of control animals. There are no significant differences between the control and centrifuged animals with regard to secretory granules, large secretory granules, lysosomes, vacuolar bodies and lipid droplets. These findings suggest that the secretory activity of the parathyroid gland may be stimulated in response to hypergravity environment.

Animals↗
PubMed1988

Effects of starvation on the parathyroid glands in golden hamsters of different ages, with special reference to the frequency of lipid droplets.

The frequency of lipid droplets in the parathyroid glands of young, adult and senile golden hamsters after starvation was investigated. In the parathyroid glands of the young and senile golden hamsters, the number of lipid droplets increased to reach a peak by 2 days, then decreased slowly by 5 days after starvation, and decreased rapidly after refeeding. In the glands of adult animals it increased to reach a peak by 5 days after starvation and decreased rapidly after refeeding. These findings suggest that in the fasting condition there is a relationship between the number of lipid droplets and aging.

Aging↗
PubMed1988

Immunocytochemical localization of parathyroid hormone in hamster parathyroid gland.

The immunocytochemical localization of parathyroid hormone was examined in the hamster parathyroid gland by using the protein A-gold technique. Protein A-gold particles were concentrated over secretory granules, large secretory granules thought to be storage granules and Golgi vacuoles. No protein A-gold particles were detected over large vacuolar bodies and cisternae of the granular endoplasmic reticulum.

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