PubMed Health⌕ Search

Biomedical subjects

H István

Publications and source records attributed to H István.

15 recordsLinked to original sources
PubMed1996

[Successful surgical management of cardiovascular thrombosis and aortic coarctation, caused by protein C deficiency, in a newborn infant].

10 days old newborn with coarctation of aortae had multiple thrombus formation in the left atria and aortic arch. At first step aortic isthmus reconstruction and thrombectomy was performed, which were followed by the multiple thrombectomy from mitral valve and aortic arch by extracorporeal circulation. Laboratory findings showed protein C deficiency. This is the first reported case with multiple thrombotic formation caused by protein C deficiency and aortic isthmus stenosis successfully operated on.

Aorta, Thoracic↗
PubMed1995

[The ipriflavone story].

Ipriflavone is an original molecule. Its introduction took a complicated course first in veterinary use as a fodder additive then after checking out its antianginal effects it was registered and launched as an effective osteoporotic agent first in Japan 1988 nineteen years after the elaboration of the synthesis of the active ingredient. Dr. László Feuer who started and managed the research died after a short sickness in 1984 and so didn't live to see the success of ipriflavone.

Angina Pectoris↗
PubMed1995

[Synthesis of isoflavones].

Construction of isoflavon skeleton is the keystep in the ipriflavon synthesis. Preparation of isoflavons is widely covered through the intermediats 2-hydroxyphenyl benzyl ketone and 2-hydroxychalcone. Other synthetic methods are also described.

Indicators and Reagents↗
PubMed1995

[Forced stability study of ipriflavone].

Forced stability study of ipriflavone has been conducted on solid state and in solution using different chromatographic techniques (TLC, HPLC, LC-TSP-MS) for measurement and identification. In solid state effect of high temperature, UV irradiation and that of artificial daylight were studied. In solution susceptibility to hydrolysis and oxidative ability were investigated. It was found that ipriflavone is stable in solid form at high temperature and against UV and daylight irradiation. In solution at high pH (pH > or = 9) ipriflavone is hydrolized and (2-hydroxy-4-isopropoxy-phenyl)benzyl-ketone develops as the main degradation product. Using hydrogen-peroxide or alpha,alpha'-asoisobutyronitrile ipriflavone can be oxidized, developing 2,3-dihydro-2,3-oxo-ipriflavone.

Chromatography↗
PubMed1995

[Characterization of ipriflavone structure by instrumental examination].

The elucidation of the chemical structure of lpriflavone was carried out by ultraviolet absorption spectrophotometric, infrared spectroscopic, 1H and 13C nuclear magnetic resonance spectroscopic, low and high resolution EI mass spectrometric, thermoanalytical, elemental analytical and X-ray diffraction methods. The results unambigously verify the structure of Ipriflavone.

Isoflavones↗
PubMed1976

[Substitution of skull defects with methyl acrylate].

On the basis of the data of the literature and their own experiences the theoretical and pratical problems of cranioplasty are dealt with by the authors. The indications of the cranioplasty and the various materials employed are discussed. In the author's opinion, the metacrylate polymerizating to heat has been found the most practical. The use of the metacrylate implant, the modelling and the preparation of the implant, as well as a new method worked out by the authors are discussed. The operative technique, the results and the possible complications are dealt with. Also the authors' new method in order to prevent the infection from the nasal cavity is described.

Acrylates↗
PubMed1975

[Soft tissue complications and their reconstruction following osteosynthesis of open tibial fractures].

The nowadays accepted principles of the treament of open leg fractures are discussed. The open character of the lesion multiplies the possibilities of complications. In the present paper the complications of the bone recovery are not dealt with, only the complications observed in the soft parts and the possibilities of their treatment are analysed by the authors. According to the severity of the soft parts complications free transplantation of semi-thick skin, pedicle flap plasty, double-end graft plasty, crossed flap grafting, as well as the primary and secondary variations of these methods are used by the authors. The satisfactory results obtained with these methods even in spite of the complications are pointed out by the authors.

Fracture Fixation↗
PubMed1975

[Experience with artificial hibernation of patients with severe craniocerebral injuries].

The artificial hibernation (hypothermia) of patients with severe cranio-cerebral lesion is discussed. The authors' experiences have shown that re-establishment of the normothermia reduces considerably the symptoms of the neurovegetative syndrome, thus it contributes to the improvement of the prognosis and in many cases it assures the patient's survival. Artificial hibernation is an important task during the intensive therapy of patients with cranio-cerebral lesions.

Brain Injuries↗