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Biomedical subjects

H J Adams

Publications and source records attributed to H J Adams.

At least 19 recordsLinked to original sources
PubMed1979

[Pentoxifylline medication within the scope of leg-ulcer therapy. Results of a field study using Trental 400].

513 patients with chronic ulcers of the leg were treated with Trental 400 orally in addition to local therapy. Regarding the reduction of the symptoms: ulcer extension, coldness of the leg, paraesthesia, resting pain and improvement of walking distance, 215 patients were classified as considerably improved, 195 distinctly improved, 53 slightly improved and 44 unchanged. Four cases worsened, two cases could not be classified. The possibility of combining oral therapy with local treatment and surgical measures (skin-flaps) is shown in three case reports. Gastro-intestinal tolerance of Trental 400 was good, interactions with concomitantly administered drugs were not reported.

Administration, Oral↗
PubMed1978

[Behavior of the fasting blood sugar values in diabetics treated with oral and parenteral pentoxifylline].

Fasting blood sugar levels in hospitalized diabetics with peripheral vascular disease receiving pentoxifylline i.v. and p.o. did not-in comparison to a control group-show statistically significant changes during the observation period in well-controlled, stable diabetes mellitus (BS is less than or equal to 130 mg%); a decrease did occur in hyperglycemic patients. As a hypoglycemic drug effect was not demonstrable in the well-controlled patient-group, the decrease might well be attributable to improved dietary and antidiabetic care during the hospital-stay.

Administration, Oral↗
PubMed1977

Spinal anesthesia with bupivacaine and tetracaine in sheep.

Spinal anesthesia was performed in sheep in order to compare hyperbaric solutions of 0.375 and 0.75% bupivacaine and tetracaine. There was no significant difference between the two compounds in the duration of sensory analgesia in the anal regions nor, at 0.75% in the time required for complete regression of the block. However, at 0.375% the duration of sensory analgesia and motor block in the hind limbs and the time required for complete regression were shorter with bupivacaine. In addition to exhibiting a higher incidence and a longer duration of motor block in the hind limbs, the sheep that received tetracaine were unable to stand on the hind limbs even after complete regression of block had occurred. Although further studies are required to establish the cause of this phenomenon, we suggest this may reflect a block of proprioceptor fibers.

Anesthesia, Spinal↗
PubMed1976

Local anesthetics. 2-Diethylamino-2',6'-acylxylidides.

A series of C-alkylated derivatives of lidocaine has been synthesized, and the local anesthetic potencies were determined. Activity reached a miximum with the butyroxylidide (alpha-ethyl group), but toxicity increased regularly with the number of carboons in the side chain. Spectral data showed the compounds to exist as associated H-bonded structures, the free base most likely as intramolecularly bonded trans amides and the hydrochlorides most likely as associated cis amindes.

Anesthetics, Local↗
PubMed1976

The local anesthetic activity of saxitoxin alone and with vasoconstrictor and local anesthetic agents.

STX (saxitoxin), alone and with various vasoconstrictor and local anesthetic agents, was evaluated for its ability to produce topical anesthesia on the rabbit cornea, peripheral nerve block in the rat, and epidural anesthesia in the dog. High frequency and long duration of block can be attained if sufficiently high concentrations of STX are used, although latency is long and the doses used may produce systemic toxicity. Frequency of satisfactory blocks and mean duration of block can be increased and systemic toxicity reduced if STX is administered with a vasoconstrictor agent. Conventional local anesthetic agents also enhance the nerve blocking activity of STX. When appropriate concentrations of STX, vasoconstrictor and local anesthetic agents are used, systemic toxic effects are not manifested and the blocks produced exhibit the rapid onset and high frequency of block characteristic of the local anesthetic agent and the remarkably long duration of STX.

Anesthesia, Epidural↗