Biomedical subjects

H J Arndt

Publications and source records attributed to H J Arndt.

At least 19 recordsLinked to original sources

PubMed1989

Characterization of potassium channels in respiratory cells. I. General properties.

Potassium channels present in the basolateral membrane of respiratory epithelial cells play an important role in the process of chloride secretion. Utilizing the patch clamp technique, we examined human cultured respiratory epithelial cells derived from patients with cystic fibrosis (CF) and normals individual (N) for the existence of and for the properties of K+ channels. We obtained qualitatively and quantitatively identical results for both preparations (CF and N). K+ channels were spontaneously present in cell attached patches. The channels showed burst appearance with rapid flickering within the bursts. When the pipette was filled with 145 mmol/l KCl, a mean conductance of 131 +/- 25 pS (n = 15) was read from the I/V-curve at a clamp voltage (Vc) of 0 mV. After excision, the conductance read from the I/V-curve at Vc = 0 mV was 212 +/- 11 pS (Pipette: 145 mmol/l KCl, bath: 145 mmol/l NaCl) (n = 61). With NaCl in the pipette and KCl in the bath, a similar conductance was obtained (g = 210 pS; n = 2). When both, pipette and bath contained KCl, the conductance was increased to 302 +/- 19 (n = 7). The channel was highly selective for potassium over sodium: PK + /PNa + greater than 40. The channel open probability was only slightly voltage dependent i.e. the open probability increased slightly with depolarisation. For most of the channels one open time constant (to = 6.3 +/- 1.6 ms; n = 22) and one closed time constant (tc = 1.8 +/- 0.3 ms; n = 21) was obtained.(ABSTRACT TRUNCATED AT 250 WORDS)

Cell Membrane↗

PubMed1987

[Clinical aspects and therapy of sudden deafness. Data of a patient sample of the ear, nose, throat clinic of the Wiesbaden City Clinic 1974-1982].

1974 to 1982 202 hospitalized patients, aged 17 to 87 years, suffering from a sudden hearing loss at first were treated between 3 and 26 days (average period 13 days) with 400 mg naftidrofuryl in low molecular weight dextrans, physiologic saline solution, glucose or leavulose solutions daily. After leaving hospital the patients received 2 dragees at 100 mg naftidrofuryl thrice a day. Provided that treatment starts within four days after the occurrence the average hearing loss measured by pure-tone audiometry was 49.2 dB before and 28.9 dB after treatment. After later beginning of therapy the values amounted to 50.8 and 35.5 dB respectively. 19 patients showed a complete remission and 77% of the patients an average hearing improvement of at least 10 dB over the measured frequencies.

Adolescent↗

PubMed1984

[Spontaneous perforation of the membrane of the round window--a major cause of sudden deafness?].

In 1983, 45 out of 63 clinically treated patients with sudden hearing loss underwent an exploratory tympanotomy. In 27 cases (60%) a perforation of the round window membrane was found, whereas in 18 cases (40%) the round window membrane was intact and there was no perilymph fistula. From 1982 to the end of 1983 30 perforations of the round window membrane were found which are reported here, most of them being spontaneous perforations without any preceding trauma. Audiometrically, hearing losses were found ranging from medium to high degree. These included all types of hard hearing, such as loss of high or low tones and losses over all frequency ranges to total deafness. All patients complained of tinnitus. One-third of the patients with perforated membrane had dizziness or vertigo combined with disturbances of balance. Treatment consisted of sealing the round window membrane with a plug of fascia or periostium. When the patients were discharged, or shortly after their discharge, audiometry revealed normal hearing in three patients, improved hearing in 8 patients, no change in 14 patients, and further deterioration in 3 patients. In 8 patients with perforated membrane, the sudden hearing loss had occurred 1 to 12 months back and in 6 patients only 8 to 30 days ago. The study will continue, but we can already see from the present results that every sudden hearing loss should be examined for a possible spontaneous perforation of the round window membrane. For this reason, exploration of the round window should be done within the first few days. The study yields new knowledge of the pathogenesis of the sudden hearing loss.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed1976

[Abdominal pain caused by adhesions and their removal at laparoscopy (author's transl)].

Intra-abdominal adhesions as the cause of severe abdominal pain were diagnosed in eight patients because (1) other abdominal diseases had been excluded, (2) certain movements, but only rarely meals, precipitated or increased the pain, (3) laparoscopy had confirmed adhesions and their manipulation had caused pain. After the adhesions had been removed at laparoscopy the pain either disappeared or was decisively reduced.

Abdomen↗

PubMed1975

[Written information as a basis for the individual instructive talk before standard operations of the ENT (author's transl)].

Before any operation the patient is to be informed by his doctor thoroughly of the calculated risk between illness and operation so that he will be able to choose between the different methods of treatment. The information should not frighten the patient, but--on the other hand--should not diminish the realities of the situation. The patient's consent to the operation is only legal under the above mentioned conditions. Information-sheets have been presented to the patients before standard-operations of the ENT and have been in practice for 6 years. These sheets have been found helpful, as they are a basic source of information for the patient and a first step before a more thorough talk with his doctor which is then more informative and precise than it would be without the information recieved before hand.

Broadsides as Topic↗

PubMed1974