[Hair dressers' eczema].
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Biomedical subjects
Publications and source records attributed to H J Bandmann.
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Of 739 dermatitis patients, 4.1% showed a positive patch test reaction to benzoyl peroxide 1% in petrolatum. Forty-one patients with leg ulcers (patch test: negative to benzoyl peroxide) were treated with a 20% benzoyl peroxide emulsion for 4 weeks. After this therapy, the sensitization rate was as high as that for the maximization test, namely 76%. In most patients, the post-therapeutic allergy to benzoyl peroxide was accompanied by contact allergies to other therapeutic agents applied. Only 9 of 31 sensitized patients showed a monovalent benzoyl peroxide allergy. From the allergologic point of view, benzoyl peroxide cannot be recommended for the treatment of leg ulcers. However, there appears to be no danger in the treatment of acne vulgaris.
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A patient reported that she developed various shock-like symptoms upon intake of alcohol, acetylsalicylic acid, or after injection of contrast medium. After provocation with alcohol applied orally and following endoscopy flush, tachycardia, and a severe headache followed immediately by painful diarrhea were observed. According to our diagnosis the patient had urticaria pigmentosa involving the bone marrow and an enlarged liver and spleen, respectively. The suspected intestinal mastocytosis was confirmed histologically by a biopsy from the jejunum. It was concluded that the symptoms were the result of a direct activation of the accumulated intestinal mast cells. The differential diagnosis of mastocytosis as opposed to allergic gastroenteritis, sprue, and carcinoid is discussed.
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Forty patients who showed more than two positive reactions to a standard patch test series of 26 substances were retested subsequently with the allergens that had given positive responses; 13 of 151 reactions were negative in the repetition, that is, 8.6% in comparison with 42% in the investigations of Mitchell (1977) in which 38 of 90 reactions could not be reproduced. Possible causes of this difference are discussed.
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The most frequent localization of atopic dermatitis are the hands. In 1976--1979, 33% of 1696 patch tested patients in the City Hospital München-Schwabing suffered from a hand dermatitis, almost 5% from an atopic dermatitis of the hands. These figures are compared with corresponding data of other authors. Besides, criteria of diagnosis of the atopic dermatitis of the hands are discussed. A concomitant contact allergy is not rare.
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A case of extensive extramammary Paget's disease in the scrotum and penis is demonstrated. The disease started a few years before as eczema-like lesions. No underlying carcinoma was found. The surgical excision resulted in a good cosmetic effect.
A 39 year-old man developed on trunk, buttock and thighs scaling, atrophic, erythematous lesions which in some places became infiltrated and ulcerated. The clinical, histopathological and immunlogical picture corresponded with the diagnosis of discoid lupus erythematosus. In sites of infiltrations and necrosis, however, histological features of panniculitis with proliferative and inflammatory changes of deep vessels could be seen. The direct immunofluorescence of uninvolved skin showed deposits of IgM and C3 at the dermal-epidermal junction and within the vessel walls. The patient responded promptly to treatment with chloroquine.
A 14-year old boy developed lesions, which clinically and histopathologically corresponded to the rare condition known under the term of lichen purpuricus seu aureus. The disease can be classified close to purpura pigmentosa progressiva.
Benzocaine-reactive patients were patch tested to two commercial sources of glyceryl p-aminobenzoate containing varying concentrations of benzocaine as a contaminant. Eleven of 20 reacted to the source with approximately 0.3% benzocaine; none reacted to the source with approximately 0.001% benzocaine.
Triclocarban was subjected to a profiling of its dermatitis producing potential including irritancy (21-day cumulative irritancy potential and application to 213 normal controls), phototoxicity (method of Marzulli), predictive contact sensitization (modified Draize method), predictive phototesting and battery screening in 2200 dermatitis patients, in an effort to define its relative dermatitis potential. The allergic contact dermatitis potential of triclocarban following bar soap use appears minimal.