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Biomedical subjects

H J Becker

Publications and source records attributed to H J Becker.

At least 19 recordsLinked to original sources
PubMed1992

A case of hidden receptacle-adapter incompatibility.

Connection of a universal VS-1 adapter to a VS-1 receptacle resulted in intermittent loss of pacing and of sensing in a pacemaker dependent patient. This was caused by the use of an adapter that only provides stable electric contact if the adapter pin is deformed by the set screw. Since we had implanted a pulse generator with a "side-lock" connector without screws, only a loose connection was achieved. The manufacturers should provide information on such hidden incompatibilities.

Adult↗
PubMed1992

[Duration of the effect and dose-response relationship of ridazolol in patients with coronary heart disease].

The dose-effect relation and duration of action of 10 mg, 20 mg, 40 mg, and 80 mg ridazolol on ischemic ST-segment depression in exercise-ECG were determined in a randomized, double-blind, acute, cross-over study of 15 patients with confirmed coronary artery disease and reproducible ST-segment depression. Maximal reduction of ST-segment depression in comparison to placebo during constant exercise was 0.16 vs. 0.25 mm (n.s.) after 10 mg, 0.09 vs. 0.25 mm (p less than 0.01) after 20 mg, 0.11 vs. 0.25 mm (p less than 0.01) after 40 mg, and 0.07 vs. 0.25 mm (p less than 0.01) after 80 mg ridazolol. A remarkable reduction of ST-segment depression under placebo was seen in the third and fifth hours after application. Systolic blood pressure under exercise was reduced significantly after 80 mg ridazolol (145 vs. 176 mm Hg; (p less than 0.05) over a period of 5 h. Heart-rate was reduced significantly after 80 mg ridazolol (102 vs. 131/min; p less than 0.05) for 5 h. Rate-pressure product after 20 mg (174 vs. 234 mm Hg/min; p less than 0.01), 40 mg (169 vs. 234 mm Hg/min; p less than 0.01), and 80 mg (153 vs. 234 mm Hg/min; p less than 0.01) ridazolol was reduced significantly over 3 to 5 h. 20, 40 and 80 mg ridazolol show a good antianginal and antihypertensive efficacy. Blood pressure and heart-rate under exercise were significantly reduced over 5 h. In contrast, improvement of ST-segment depression only lasted 1 h. Ridazolol was well tolerated.

Adrenergic beta-Antagonists↗
PubMed1991

Clinical chronopharmacology of oral sustained-release isosorbide-5-mononitrate in healthy subjects.

In 10 healthy male subjects the pharmacokinetics and haemodynamic effects of sustained-release isosorbide-5-mononitrate 60 mg (IS-5-MN) were studied after oral administration at two different times in the day (08.00 h and 20.00 h). Effects on blood pressure and heart rate after 3 min standing upright were measured in relation to the individual circadian control values. The pharmacokinetic parameters (Cmax, tmax, AUC, t 1/2) did not differ after morning and after evening dosing, tmax being 5.2 h and 4.9 h, respectively. In contrast, the cardiovascular effects of IS-5-MN were clearly circadian phase-dependent. The maximum decrease in blood pressure decrease and increase in heart rate occurred significantly earlier after the evening (BPsys 2.8 h; BPdia 2.9 h; HR 3.8 h) than after the morning dose (BPsys 5.0 h; BPdia 6.0 h; HR 5.2 h). Thus, the peak haemodynamic effects coincided with the peak drug concentration after the morning dose, whereas the peak effect was in advance of the peak drug concentration after the evening dose of IS-5-MN. The data provide evidence of circadian phase-dependency in the dose-response relationship of oral IS-5-MN.

Administration, Oral↗
PubMed1989

Clinical chronopharmacology of oral nitrates.

The clinical-chronopharmacological investigations with oral nitrates (ISDN, IS-5-MN) demonstrate that the drugs' pharmacokinetics and/or hemodynamic effects are circadian phase-dependent. For both an immediate-release and a sustained-release preparation of IS-5-MN peak drug concentrations coincided with peak drug effects after morning but not after evening drug application. Results indicate a circadian phase-dependency in the dose-response relationship of oral nitrates.

Administration, Oral↗
PubMed1978

[Diagnosis, therapy and longterm results of atrial myxoma (author's transl)].

Refering to a case report of five patients with atrial myxoma the symptoms, diagnosis, and therapy of this disease were described. In one case a biatrial tumor was found. In four cases atrial myxoma imitated a mitral-valve disease. An elevated BSR was found in all patients. The non invasive diagnostic procedure of ultrasound-echocardiography led in the last two cases to the correct diagnosis before heart-catheterization. The diagnosis was ascertained in all cases by angiocardiography. If left atrial tumor is suspected transpulmonary laevocardiography can be considered as a save diagnostic procedure better than the direct injection into the left atrium after transseptal puncture. Even the left ventricular angiogram in right anterior oblique position led in four of the five cases to the diagnosis of left atrial tumor. Coronary-angiography was performed in three patients and revealed pathologic atrial vessels in all three cases. Immediate operation is the indicated therapy. Two of the five patients were reviewed over a eight year period after operation without any signs of recurrence of the tumor.

Adult↗
PubMed1978

Curricula of associate degree mental health/human-services training programs.

Over 100 community college programs engaged in training people for mental health/human-services employment were studied in order to describe the curriculum most generally offered and variations most frequently found. In general, the programs have developed similarly: major emphasis on experiential learning of group dynamics, on techniques of interpersonal assistance, and on apprenticeship field work experience; and lesser emphasis on the organizational aspects of care and on relevant theoretical literature. Nevertheless, substantial differences exist between programs; for example, the specialization of the curriculum, the credit awarded for field work experience, and the types of settings used for field placements.

Attitude↗
PubMed1977

Heterochromatin of the Drosophila melanogaster Y chromosome as modifier of position effect variegation: the time of its action.

Addition of heterochromatin suppresses while subtraction enhances position effect variegation. The heterochromatin-sensitive period has been determined in white/white-apricot variegated eyes of YSWa/Wa; Dp (1,3)W264-58 flies. When such larvae, carrying a Y-short (YS) arm at the distal end of one X chromosome, are X-rayed, mitotic recombination leads to one daughter cell with two YS arms and an adjacent daughter cell with no YS arm. When induced after clonal initiation, the frequency of dark clones developing from daughter cells with two YS arms is significantly higher than the frequency of dark clones in the rest of the eye; and this frequency is even higher when induced before clonal initiation. The modifying action of the Y-heterochromatin is exerted, therefore, during and after clonal initiation. Surprisingly, the frequency of dark clones developing from cells with no YS arm is not lower than the frequency of dark clones in the rest of the eye.

Animals↗
PubMed1976

[Specific and non-specific effects of beta-adreno-receptor blocking drugs in man (author's transl)].

The effect of tyramine infusion or exercise on catecholamine concentration and dopamine-beta-hydroxylase activity in plasma of normal volunteers has been studied. Whereas the increase in plasma catecholamine concentrations by tyramine infusion was not changed 90 min after oral application of a single dose of beta-adrenoceptor blocking drugs (penbutolol, practolol, I.C.I. 66082), the increase in blood pressure was diminished. However, the increase in plasma catecholamine, concentration, i.e. the adrenergic response to exercise was significantly enhanced during beta-adrenoceptor blockade. On the other hand, dopamine-beta-hydroxylase activity was not further increased during beta-adrenoceptor blockade. - The non-specific membrane activity of the beta-adrenoceptor blocking drugs wass assessed by the degree of inhibition of serotonin uptake by human platelets in vitro. Their order of potency, according to IC 50 values estimated from the dose response curves was: propranolol less than penbutolol less than practolol less than I.C.I. 66082. The inhibitory activity of these drugs in vivo was also studied by measuring serotonin uptake by platelets isolated 90 min after oral administration. Due to the high dose only propranolol showed a marked membrane activity.

Adrenergic beta-Antagonists↗
PubMed1976

[Coronary arteriography in patients with Prinzmetal's angina associated with ST elevations (author's transl)].

Among 1000 patients with coronary heart disease studied at rest and on exercise and by coronary arteriography, 17 had ST elevations during the anginal episodes. ST changes during exercise occurred in 16 patients, 12 of whom had spontaneous angina. One patient had ST changes only during spontaneous attacks at rest. Critical proximal lesions in the descending branch of the left anterior coronary artery were revealed by coronary arteriography in all 17 patients. Biplane ventricular cine-angiography revealed slight abnormalities in 12, normal pattern in the other five. It is thought that ST elevation during anginal attacks is caused by severe transmural ischaemia. Spontaneous attacks are thought to be due to additional functional narrowing, probably resulting from an increased vascular tone within the area of obstruction.

Angina Pectoris↗
PubMed1976

[Results of gastric lymphography with particular reference to gastric carcinoma (author's transl)].

The regional lymph nodes of the stomach can be visualised radiologically by injecting Lipiodol Ultra-Fluid into the submucous layer of the stomach wall through a gastroscope. Lymphography was performed in gastrologically healthy probands (n = 10), in patients with gastroduodenal ulceration (n = 17), and in patients with gastric carcinoma (n = 35). In 28 of the gastric carcinoma patients the first order lymph nodes were demonstrated, in 21 cases the second order and in 15 cases the third order whereas defects in uptake indicated metastases in 16 patients which could be histologically confirmed in 13. Gastric lymphography may contribute to the indication for operation if metastases are suspected in the second and third order lymph nodes as nodes along the upper border of the pancreas and the coeliac trunk are very difficult to remove radically.

Female↗
PubMed1976

[Surgical treatment of ventricular aneurysm: an analysis of post-resection haemodynamic changes (author's transl)].

Of 500 patients with angiographically proven myocardial infarction 75 had a left ventricular aneurysm. 25 of them subsequently had resection of the aneurysm. Postoperative studies revealed marked improvement of symptoms. Pulmonary arterial pressure was significantly decreased at rest (from 28 to 20 mm Hg) and on exercise (from 58 to 35 mm Hg). There was a reduction in left ventricular end-diastolic volume (from 247 to 1.54 ml/1.73 m2) and a raised ejection fraction (from 36 to 59%). Good results were obtained especially in those patients who had congestive heart failure due to paradoxical systolic expansion of the ventricular wall and (or) secondary reversible damage in the remaining viable myocardium. Left ventricular aneurysms should be suspected after myocardial infarction when there is left ventricular failure and an increase in heart size.

Adult↗
PubMed1975

[Differentialdiagnosis and surgical treatment of the familial intestinal polyposis (author's transl)].

Between 1959 and 1974 we observed 18 patients with familial intestinal polyposis. 4 patients were from one family. Two brothers refused the operation and died 7 respectively 8 years after diagnosis had been made. The typical symptoms, the diagnostic procedure and the therapy are demonstrated. We prefer the proctocolectomy (eventually with the "Kock-Ileostoma"), because we observed a lot of recidivs after ileorectostomy. The prognosis of the familial intestinal polyposis is good, if the operation is performed early (also in cases of carcinomatosis). Only those patients died, who rejected the operation or were operated too late.

Adolescent↗
PubMed1975

[Pre- and postoperative investigations of patients after aortic valve replacement with prosthetic valves or homografts (author's transl)].

Two groups of patients with aortic-valve disease were compared. Group I (18 patients) received prosthetic valves, group II (12 patients) homograft valves. The symptoms and haemodynamic findings improved in both groups, postoperatively. Complications were more frequent with prosthetic than homograft valves, and the haemodynamic responses also were better in the homograft group, especially during exercise.

Adult↗
PubMed1975

X-ray- and TEM-induced mitotic recombination in Drosophila melanogaster: unequal and sister-strand recombination.

Twin mosaic spots of dark-apricot and light-apricot ommatidia were found in the eyes of wa/wa females, of wa males, of females homozygous for In(1)sc4, wa and of attached-X females homozygous for wa. The flies were raised from larvae which had been treated with 1630 R of X-rays at the age of 48-52 hours. An additional group of wa/wa females and wa males came from larvae that had been fed with triethylene melamine (TEM) at the age of 22-24 hours. The twin spots apparently were the result of induced unequal mitotic recombination, i.e. from unequal sister-strand recombination in the males and from unequal sister-strand recombination as well as, possibly, unequal recombination between homologous strands in the females. That is, a duplication resulted in waDp wa/wa dark-apricot ommatidia and the corresponding deficiency in an adjacent area of wa/Df wa light-apricot ommatidia. In an additional experiment sister-strand mitotic recombination in the ring-X chromosome of ring-X/rod-X females heterozygous for w and wco is believed to be the cause for X-ray induced single mosaic spots that show the phenotype of the rod-X marker.

Drosophila melanogaster↗