Activation and functions of CD4+ T-cell subsets.
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Animals↗
Biomedical subjects
H J Burstein
Publications and source records attributed to H J Burstein.
Degree of unsaturation of the fatty acid chains of phospholipids influences the fluorescence polarization: implications for evaluating fetal lung maturity.
To study the effect of fatty acid chain saturation on the fluorescence polarization assay as a measure of fetal lung maturity, we used purified phospholipids isolated from human amniotic fluid and various commercial phospholipids. We found that the fluorescence polarization value decreased as the concentration of unsaturated fatty acids increased. In contrast, the lecithin/sphingomyelin ratio increases with increasing amounts of saturated lecithin, produced as the fetal lung matures. Since only saturated lecithins are surface active, the two indices of fetal respiratory status must reflect different properties of lung surfactant.
Amniotic Fluid↗
Benign angiolymphoid hyperplasia with eosinophilia.
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Aged↗
Functional phospholipid/sphingomyelin ratio: an easy to interpret indicator of fetal lung maturity.
Data are presented which show that the functional phospholipid/sphingomyelin (FPL/S) ratio is a sensitive and specific prenatal indicator of fetal respiratory status. Phospholipids included in the ratio are acetone precipitable lecithin(L), phosphatidylglycerol(PG), phosphatidylethanolamine(PE), and sphingomyelin(S). These lipids have been shown to contribute to either the lowering of surface tension or to changes in microviscosity. Both of these properties contribute independently to the physiologic effectiveness of fetal lung surfactant. Although other phospholipid profiles have been described in the literature, the FPL/S ratio accounts for the major phospholipids which contribute to lung surfactant function with the added advantage of presenting the data in the form of a single easy to interpret number. Clinical correlates are also presented for the L/S ratio, fluorescence polarization assay (using 1,6-diphenyl-3,5-hexatriene), and absorbance at 650 nanometers.
Amniotic Fluid↗