Morphological and functional evaluation of the quality of preservation of the rat pancreas.
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Adenosine↗
Biomedical subjects
H J Coone
Publications and source records attributed to H J Coone.
[Injuries of the small and large intestine].
While laparotomy is always mandatory for penetrating injuries of the intestine, its indication for blunt trauma is still difficult because of diagnostic problems. Late interventions are responsible for a poor prognosis in these patients. While the operative management of small bowel ruptures is mostly unproblematic injury of the large intestine demands more differential treatment. In cases of contaminated abdominal cavity and the necessity of bowel resection a so-called anastomosis stoma should be used if possible. In case of major trauma of the rectosigmoid, a Hartmann procedure may be necessary. Profuse drainage and colostomy are required in cases of trauma of the extraperitoneal part of the rectum.
Abdominal Injuries↗
Differential sensitivity of rat exocrine and endocrine pancreas to cyclosporine.
The effect of 5, 10, and 20 mg/kg bw cyclosporine on rat endocrine and exocrine pancreatic function was studied. Glucose-dependent insulin secretion from the endocrine pancreas was shown to be significantly impaired 8 days after cyclosporine was given once daily at a dose as low as 5 mg/kg. CCK-8-stimulated amylase and lipase secretion were less sensitive to the noxious effect of cyclosporine being impaired at a dose of 10 mg/kg. Trypsin secretion was shown to be impaired at 20 mg/kg cyclosporine only. Our results demonstrate that cyclosporine causes dose-dependent impairment of both pancreatic endocrine and exocrine functions: the endocrine pancreas being more sensitive to the noxious action than the exocrine pancreas.
Amylases↗
[Colonic perforation].
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Anti-Bacterial Agents↗
[Surgical therapy in colon perforations].
Diagnosis of colon perforation is an absolute indication for surgery. Therapy should include removal of the perforated colon section. Continuity resection should be preceded by colostomy for higher safety.
Anastomosis, Surgical↗