Biomedical subjects
Publications and source records attributed to H J Cramer.
We report on a female patient with a severe allergic contact dermatitis of the lower legs due to Varicosan, a special bandage material for varicosis. We found a sensitization against methyl- and propylesters of parahydroxybenzoic acid. This preservatives could be identified in Varicosan bandages.
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Elucidation of pathogenesis is a major prerequisite for successful treatment of chronic vulvar pruritus. With the great number of episiotomies in modern obstetrics, episiotomy scars count as possible cause of pruritus. Traumatic terminal-fibre neuroma was established as pathogenetic factor in one case. Such almost a structural tumour was not histologically recordable unless special methods were applied.
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The pigmentation of epidermis in areas of nevus-cell nevi is frequently not specially noted, but may be of considerable diagnostic value in particular cases. Two cases are demonstrated. Multiple tumors with the aspect of nevus Spitz in a 35-year old woman were histologically diagnosed by means of melanin impregnation methods as "amelanotic nevus-cell nevi with overlying vitiligo". A flat papillomatous nevus-cell nevus of the abdominal skin of a 38-year old man showed clinical signs of activity, but histologically only a total depigmentation of the epidermis and of the peripheral parts of the nevus was observed.
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In the past, the nevus spilus was differently interpreted. Ito and Hamada, however, limited this term to a pigmented macule that had darker speckles within it. This newer definition is a useful one in clinical diagnostics. But histopathologically this lesion seems not to be an entity. A review of the literature and the present study suggest that it is in all probability a café-au-lait-nevus of neurofibromatosis-type. The darker spots are different in their histopathologic structures. They are nevus-cell-nevi, nevoid lentigines, epidermal pigmented macules or localized pigment disturbances with melaninincontinence following inflammatory prozesses.
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An ulcerating and sclerosing skin tumour on the temporal forehead region is described. Histologically the tumour is composed of different structures as cystic hidradenoma, syringoma, ductal hidradenoma and sclerres as cystic hidradenoma, syringoma, ductal hidradenoma and sclerosing basalioma arranged in layers. The tumour appears to be a distinct and diagnosable entity. It exists a major similarity to such tumours reported as syringeal hidradenoma, eccrine epithelioma or eccrine basalioma.
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