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H J Friedman

Publications and source records attributed to H J Friedman.

At least 19 recordsLinked to original sources

Neurolitigation: a perspective on the elements of expert testimony for extending the Daubert challenge.

Scientific expert witness testimony has the potential for affecting most court decisions in civil and criminal proceedings. Since experts were first utilized in English courts beginning in the 14th century, most contemporary courts struggle with seeking a balance between plaintiff and defense counsel allowing each party its day in court while taking into account the work which other courts have done previously in determining the admissibility of expert witness testimony. When these challenges present themselves in the courtroom, often other courts have approached these identical issues, many in proceedings involving the same expert(s). Confronted with these challenges, trial judges want to understand whether a new Daubert hearing must be held, deal with the issue from a clean slate approach or whether they must reinvent the proverbial wheel. Given these dilemmas, this exposition is based within a heuristic approach that will focus on the consideration of comprehensive data inclusion from an evidentiary foundation as it applies to expert witness testimony admissibility in neurolitigation. While the evidential force of FRE 702 specifically applies to admissibility of scientific evidence, it makes sense that along with scientific, objective data, inclusion of non-medical and other data in forming and admitting expert opinions, have mutual bearing upon the validity of opinions arrived at through neuropsychological assessment. It is these multi-data that should be factored into account when applying the Federal Rule of Evidence 702 scientific admissibility standard. Data from other relevant sources is just as vital as data obtained from objective measures, and co-exists with objective data. Without the integration of this information into resulting diagnostic data and opinions, one's methodology is open to scrutiny and can willfully be characterized as engaging in "junk science". Specific, pragmatic issues are discussed in order to avoid the plausible "junk science" question and to ultimately arrive at a factual and evidenced-based admissibility and reliability determination for the courts. Given the current standard, this article proposes an inclusionary method in neurolitigation as it would necessarily apply to Federal Rule of Evidence 702 which would extend to the integration of data outside medical and scientific information bases to establish accurate opinions for the trier of fact. In so doing, neuropsychological test data, non-medical data and expert testimony would be strengthened through inter-data consistency.

Activities of Daily Living↗

The roles of experts and litigation support consultants in medical-legal claims.

Brain injury claims frequently involve the use of experts to evaluate and document extent of impairment. These experts can cover a wide array of specialities, many of which are delineated in this article. It is pointed out that there are crucial differences between a clinical evaluation and a medical-legal evaluation as the latter is generally more comprehensive and addresses many of the specific issues that arise in a forensic claim. It is suggested that use of a litigation support consultant can provide valuable assistance for the attorney at the outset and over the course of handling a claim such as with selection of experts and preparation for direct and cross examination of experts. Suggestions are also made about criteria for selection of experts such as to ensure that appropriate objectivity, and, consequently, admissibility of conclusions is maintained.

Brain Concussion↗

Effects of acute starvation on vitamin A status in rats.

Maintenance of vitamin A stores in the body is dependent on a number of basic metabolic processes. These processes, such as protein and carbohydrate metabolism, are disrupted in acute starvation, and, as a result, alterations in vitamin A status may result. We investigated this possibility in 8-week-old Sprague-Dawley male rats. The rats were starved for 24, 48, and 72 hr but had free access to water. At 24 hours of starvation, the plasma retinol concentration was depressed, but not significantly so. After 48 and 72 hours of starvation, however, the plasma retinol concentration decreased to less than half of the control values (61 +/- 4 vs 124 +/- 12 nmol/dl at 72 hours, mean +/- SEM, (p less than 0.005). The hepatic retinoid (retinyl esters + retinol) concentration (nmol/g liver) was increased at 24 and 48 hours of starvation compared to controls (p less than 0.05), and by 72 hours the concentration was 56% greater in starved rats than in fed controls (p less than 0.001). The total hepatic retinoid content (mumol/total liver) was decreased moderately at all periods of starvation compared to controls (p less than 0.05). In both starved and fed animals, the total hepatic content per 100 g body weight, a measure of total vitamin A reserves, was statistically the same. These results demonstrate that acute starvation in rats alters the vitamin A equilibrium between the plasma and hepatic stores without affecting the overall vitamin A reserves.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗

Ethanol-induced analgesia in rats selectively bred for ethanol sensitivity.

Two rat lines selectively bred for ethanol-induced depression of locomotor activity were studied for ethanol-induced analgesia. The effects of ethanol on startle amplitude, extent of overt movements and incidence of audible vocalizations in response to intermittent, noncontingent foot shock. All three responses were dose-dependently depressed by ethanol (0.66 to 2.0 g/kg, IP), and to greater extent in the "most affected" line (MA) than in "least affected" (LA) rats. Ethanol-induced response decrements were reinstated at higher shock intensities, indicating a sensory (i.e., analgesic) rather than a motoric or analgesic basis for these effects. Genes which influence ethanol's motoric effects might, in part, influence sensitivity to its sensory effects.

Analgesia↗

Peptide inhibitor of morphine- and beta-endorphin-induced analgesia.

The synthetic beta-endorphin analogs with the omission of the NH2-terminal [Met]enkephalin segment [beta-endorphin-(6-31) and beta-endorphin-(20-31)] are shown to inhibit morphine- or beta-endorphin-induced analgesia in mice by the tail-flick test, whereas the synthetic NH2-terminal pentadecapeptide beta-endorphin-(1-15) has no inhibitory activity. This study raises the possibility that endogenous inhibiting peptides exist in the brain which play a role in the regulation of endorphin actions.

Amino Acid Sequence↗